Resumo
Definição
História e exame físico
Outros fatores diagnósticos
- fadiga
- mialgia ou artralgia
- produção de escarro/expectoração
- constrição torácica
- sintomas gastrointestinais
- faringite
- cefaleia
- tontura
- sintomas neurológicos
- sintomas oculares
- rinorreia/congestão nasal
- dor torácica
- sintomas cutâneos
- hemoptise
- murmúrios brônquicos
- taquipneia
- taquicardia
- cianose
- estertores na ausculta
Fatores de risco
- residência/trabalho/viagem para local com alto risco de transmissão
- contato com um caso provável ou confirmado
- idade avançada
- residência em unidade de cuidados de longa permanência
- sexo masculino
- etnia
- presença de comorbidades
- doença cardiovascular
- hipertensão
- obesidade
- diabetes
- doença respiratória crônica
- doença renal crônica
- neoplasia maligna
- doença falciforme
- transplante de órgão sólido
- tabagismo
- doença cerebrovascular
- demência
- doença hepática crônica
- doença hepática gordurosa associada a disfunção metabólica
- cirurgia
- gestação
- imunossupressão
- doença autoimune
- deficiência de vitamina D
- poluição do ar
- clima e latitude
- residência em áreas urbanas ou carentes
- Uso de inibidor da enzima conversora da angiotensina (IECA)/antagonista do receptor de angiotensina II
- dislipidemia
- uso de estatina
- uso de inibidor da bomba de prótons
- Infecção pelo vírus da imunodeficiência humana (HIV)
- talassemia
- Síndrome de Down
- crianças com certas condições subjacentes
- grupo sanguíneo A
- disbiose intestinal
Investigações diagnósticas
Primeiras investigações a serem solicitadas
- reação em cadeia da polimerase via transcriptase reversa (RT-PCR) em tempo real
- oximetria de pulso
- gasometria arterial
- Hemograma completo
- perfil metabólico completo
- nível glicêmico
- coagulograma
- biomarcadores cardíacos
- proteína C-reativa sérica
- velocidade de hemossedimentação sérica
- concentração sérica de lactato desidrogenase
- nível sérico de interleucina-6
- procalcitonina sérica
- nível de ferritina sérica
- nível de amiloide A sérica
- creatinoquinase e mioglobina séricas
- hemoculturas e culturas de escarro
- radiografia torácica
Investigações a serem consideradas
- tomografia computadorizada (TC) torácica
- sorologia
- teste de antígenos
Novos exames
- amplificação isotérmica mediada por ciclo de transcrição reversa (RT-LAMP)
- ultrassonografia do pulmão
Algoritmo de tratamento
Colaboradores
Autores
Nicholas J. Beeching, MA, BM BCh, FRCP, FRACP, FFTM RCPS (Glasg), FESCMID, DCH, DTM&H
Consultant and Honorary Senior Lecturer in Infectious Diseases
Royal Liverpool University Hospital and Liverpool School of Tropical Medicine
Liverpool
UK
Declarações
NJB is partially supported by the National Institute of Health Research Health Protection Unit (NIHR HPRU) in Emerging and Zoonotic Infections at University of Liverpool in partnership with Public Health England (PHE), in collaboration with Liverpool School of Tropical Medicine. He is affiliated with Liverpool School of Tropical Medicine. The views expressed are those of the author and not necessarily those of the NHS, the NIHR, the Department of Health, or PHE.
Tom E. Fletcher, MBE, PhD, MBChB, MRCP, DTM&H
Senior Clinical Lecturer and Defence Consultant in Infectious Diseases
Royal Liverpool University Hospital and Liverpool School of Tropical Medicine
Liverpool
UK
Declarações
TEF is a consultant/expert panel member to the World Health Organization, and is funded by the UK Surgeon General, the NHS, and Liverpool School of Tropical Medicine. TEF is partially supported by the National Institute of Health Research Health Protection Unit (NIHR HPRU) in Emerging and Zoonotic Infections at University of Liverpool in partnership with Public Health England (PHE), in collaboration with Liverpool School of Tropical Medicine. He is affiliated with Liverpool School of Tropical Medicine. He has received research grants from the Wellcome Trust, Medical Research Council, and the UK Public Health Rapid Support Team (UK-PHRST). The views expressed are those of the author and not necessarily those of the NHS, the NIHR, the Department of Health, or PHE.
Robert Fowler, MDCM, MS (Epi), FRCP(C)
H. Barrie Fairley Professor of Critical Care
University Health Network and Interdepartmental Division of Critical Care Medicine
Director
Clinical Epidemiology and Health Care Research
Institute of Health Policy, Management and Evaluation
Dalla Lana School of Public Health
University of Toronto
Chief
Tory Trauma Program
Sunnybrook Hospital
Toronto
Canada
Declarações
RF declares that he has no competing interests.
Revisores
William A. Petri, Jr., MD, PhD
Professor
Division of Infectious Diseases and International Health
University of Virginia
Charlottesville
VA
Declarações
WAP declares that he has no competing interests.
Xin Zhang, MD, PhD
Attending Physician
The Fifth Medical Center of PLA General Hospital
Clinical Division and Research Center of Infectious Disease
Beijing
China
Declarações
XZ declares that he has no competing interests.
Ran Nir-Paz, MD
Associate Professor in Medicine
Department of Clinical Microbiology and Infectious Diseases
Hadassah Hebrew University Medical Center
Jerusalem
Israel
Declarações
RNP has received research grants from US-Israel Binational Science Foundation, Hebrew University, Rosetrees Trust, and SpeeDx. He is chair of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Mycoplasma and Chlamydia Infections (ESGMAC). RNP is a consultant for and has stocks in eDAS Healthcare. He is also chairperson of the Israeli Society for Infectious Diseases guidelines committee.
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