Doença do coronavírus 2019 (COVID-19)

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31. World Health Organization. Prevention, identification and management of health worker infection in the context of COVID-19. 2020 [internet publication].Texto completo external link opens in a new window

32. CDC COVID-19 Response Team. Characteristics of health care personnel with COVID-19: United States, February 12 –April 9, 2020. MMWR Morb Mortal Wkly Rep. 2020 Apr 17;69(15):477-81.Texto completo external link opens in a new window Resumo external link opens in a new window

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35. Shah ASV, Wood R, Gribben C, et al. Risk of hospital admission with coronavirus disease 2019 in healthcare workers and their households: nationwide linkage cohort study. BMJ. 2020 Oct 28;371:m3582.Texto completo external link opens in a new window Resumo external link opens in a new window

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39. Lu R, Zhao X, Li J, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet. 2020 Feb 22;395(10224):565-74.Texto completo external link opens in a new window Resumo external link opens in a new window

40. Public Health England. Investigation of novel SARS-CoV-2 variants of concern. 2021 [internet publication].Texto completo external link opens in a new window

41. Scientific Advisory Group for Emergencies. NERVTAG: update note on B.1.1.7 severity, 11 February 2021. 2021 [internet publication].Texto completo external link opens in a new window

42. Challen R, Brooks-Pollock E, Read JM, et al. Risk of mortality in patients infected with SARS-CoV-2 variant of concern 202012/1: matched cohort study. BMJ. 2021 Mar 9;372:n579.Texto completo external link opens in a new window Resumo external link opens in a new window

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45. Centers for Disease Control and Prevention. SARS-CoV-2 variant classifications and definitions. 2021 [internet publication].Texto completo external link opens in a new window

46. World Health Organization. SARS-CoV-2 mink-associated variant strain: Denmark. 2020 [internet publication].Texto completo external link opens in a new window

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49. Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020 Feb 15;395(10223):497-506.Texto completo external link opens in a new window Resumo external link opens in a new window

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54. Zhang T, Wu Q, Zhang Z. Probable pangolin origin of SARS-CoV-2 associated with the COVID-19 outbreak. Curr Biol. 2020 Apr 6;30(7):1346-51.Texto completo external link opens in a new window Resumo external link opens in a new window

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56. Mallapaty S. Animal source of the coronavirus continues to elude scientists. Nature. 2020 May 18 [Epub ahead of print].Texto completo external link opens in a new window Resumo external link opens in a new window

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839. Medicines and Healthcare products Regulatory Agency. Interleukin-6 inhibitors (tocilizumab or sarilumab) for hospitalised patients with COVID-19 pneumonia (adults). 2021 [internet publication].Texto completo external link opens in a new window

840. RECOVERY Collaborative Group; Horby PW, Pessoa-Amorim G, Peto L,et al; medRxiv. Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): preliminary results of a randomised, controlled, open-label, platform trial. 2021 [internet publication].Texto completo external link opens in a new window

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842. National Institute for Health and Care Excellence. COVID-19 rapid evidence summary: tocilizumab for COVID-19. 2021 [internet publication].Texto completo external link opens in a new window

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845. Tharmarajah E, Buazon A, Patel V, et al. IL-6 inhibition in the treatment of COVID-19: a meta-analysis and meta-regression. J Infect. 2021 Mar 18 [Epub ahead of print].Texto completo external link opens in a new window Resumo external link opens in a new window

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854. Lescure FX, Honda H, Fowler RA, et al. Sarilumab in patients admitted to hospital with severe or critical COVID-19: a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Respir Med. 2021 Mar 4 [Epub ahead of print].Texto completo external link opens in a new window Resumo external link opens in a new window

855. Rubin EJ, Longo DL, Baden LR. Interleukin-6 receptor inhibition in Covid-19: cooling the inflammatory soup. N Engl J Med. 2021 Feb 25 [Epub ahead of print].Texto completo external link opens in a new window Resumo external link opens in a new window

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857. European Medicines Agency. Veklury. 2020 [internet publication].Texto completo external link opens in a new window

858. US Food and Drug Administration. FDA approves first treatment for COVID-19. 2020 [internet publication].Texto completo external link opens in a new window

859. WHO Solidarity Trial Consortium., Pan H, Peto R, et al. Repurposed antiviral drugs for Covid-19: interim WHO Solidarity trial results. N Engl J Med. 2020 Dec 2 [Epub ahead of print].Texto completo external link opens in a new window Resumo external link opens in a new window

860. US Food and Drug Administration. Coronavirus (COVID-19) update: FDA authorizes monoclonal antibodies for treatment of COVID-19. 2021 [internet publication].Texto completo external link opens in a new window

861. European Medicines Agency. EMA issues advice on use of REGN-COV2 antibody combination (casirivimab/imdevimab). 2021 [internet publication].Texto completo external link opens in a new window

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863. Regeneron Pharmaceuticals, Inc. REGN-COV2 independent data monitoring committee recommends holding enrollment in hospitalized patients with high oxygen requirements and continuing enrollment in patients with low or no oxygen requirements. 2020 [internet publication].Texto completo external link opens in a new window

864. Regeneron Pharmaceuticals, Inc. Phase 3 trial shows REGEN-COV™ (casirivimab with imdevimab) antibody cocktail reduced hospitalization or death by 70% in non-hospitalized COVID-19 patients. 2021 [internet publication].Texto completo external link opens in a new window

865. Regeneron Pharmaceuticals, Inc. Regeneron reports positive interim data with REGEN-COV™ antibody cocktail used as passive vaccine to prevent COVID-19. 2021 [internet publication].Texto completo external link opens in a new window

866. US Food and Drug Administration. Coronavirus (COVID-19) update: FDA authorizes monoclonal antibody for treatment of COVID-19. 2020 [internet publication].Texto completo external link opens in a new window

867. European Medicines Agency. EMA issues advice on use of antibody combination (bamlanivimab / etesevimab). 2021 [internet publication].Texto completo external link opens in a new window

868. Eli Lilly and Company. Lilly statement regarding NIH’s ACTIV-3 clinical trial. 2020 [internet publication].Texto completo external link opens in a new window

869. ACTIV-3/TICO LY-CoV555 Study Group; Lundgren JD, Grund B, Barkauskas CE, et al. A neutralizing monoclonal antibody for hospitalized patients with Covid-19. N Engl J Med. 2020 Dec 22 [Epub ahead of print].Texto completo external link opens in a new window Resumo external link opens in a new window

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871. Eli Lilly and Company. Lilly's neutralizing antibody bamlanivimab (LY-CoV555) prevented COVID-19 at nursing homes in the BLAZE-2 trial, reducing risk by up to 80 percent for residents. 2021 [internet publication].Texto completo external link opens in a new window

872. Eli Lilly and Company. Lilly's bamlanivimab and etesevimab together reduced hospitalizations and death in phase 3 trial for early COVID-19. 2021 [internet publication].Texto completo external link opens in a new window

873. US Food and Drug Administration. FDA in brief: FDA updates emergency use authorization for COVID-19 convalescent plasma to reflect new data. 2021 [internet publication].Texto completo external link opens in a new window

874. Medicines and Healthcare products Regulatory Agency. Convalescent plasma in the management of hospitalised patients with COVID-19. 2021 [internet publication].Texto completo external link opens in a new window

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876. Imperial College London. Blood plasma treatment has limited effect for sickest COVID-19 patients. 2021 [internet publication].Texto completo external link opens in a new window

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879. Libster R, Pérez Marc G, Wappner D, et al. Early high-titer plasma therapy to prevent severe Covid-19 in older adults. N Engl J Med. 2021 Jan 6 [Epub ahead of print].Texto completo external link opens in a new window Resumo external link opens in a new window

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881. National Institutes of Health. NIH halts trial of COVID-19 convalescent plasma in emergency department patients with mild symptoms. 2021 [internet publication].Texto completo external link opens in a new window

882. US Food and Drug Administration. Coronavirus (COVID-19) update: FDA authorizes drug combination for treatment of COVID-19. 2020 [internet publication].Texto completo external link opens in a new window

883. Kalil AC, Patterson TF, Mehta AK, et al. Baricitinib plus remdesivir for hospitalized adults with Covid-19. N Engl J Med. 2020 Dec 11 [Epub ahead of print].Texto completo external link opens in a new window Resumo external link opens in a new window

884. Caly L, Druce JD, Catton MG, et al. The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro. Antiviral Res. 2020 Jun;178:104787.Texto completo external link opens in a new window Resumo external link opens in a new window

885. European Medicines Agency. EMA advises against use of ivermectin for the prevention or treatment of COVID-19 outside randomised clinical trials. 2021 [internet publication].Texto completo external link opens in a new window

886. Padhy BM, Mohanty RR, Das S, et al. Therapeutic potential of ivermectin as add on treatment in COVID 19: a systematic review and meta-analysis. J Pharm Pharm Sci. 2020;23:462-9.Texto completo external link opens in a new window Resumo external link opens in a new window

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888. National Institute for Health and Care Excellence. COVID 19 rapid evidence summary: anakinra for COVID-19 associated secondary haemophagocytic lymphohistiocytosis. 2020 [internet publication].Texto completo external link opens in a new window

889. Cavalli G, De Luca G, Campochiaro C, et al. Interleukin-1 blockade with high-dose anakinra in patients with COVID-19, acute respiratory distress syndrome, and hyperinflammation: a retrospective cohort study. Lancet Rheumatol. 2020 Jun;2(6):e325-31.Texto completo external link opens in a new window Resumo external link opens in a new window

890. Cavalli G, Larcher A, Tomelleri A, et al. Interleukin-1 and interleukin-6 inhibition compared with standard management in patients with COVID-19 and hyperinflammation: a cohort study. Lancet Rheumatol. 2021 Feb 3 [Epub ahead of print].Texto completo external link opens in a new window Resumo external link opens in a new window

891. Huet T, Beaussier H, Voisin O, et al. Anakinra for severe forms of COVID-19: a cohort study. Lancet Rheumatol. 2020 Jul;2(7):e393-400.Texto completo external link opens in a new window Resumo external link opens in a new window

892. Navarro-Millán I, Sattui SE, Lakhanpal A, et al. Use of anakinra to prevent mechanical ventilation in severe COVID-19: a case series. Arthritis Rheumatol. 2020 Jun 30 [Epub ahead of print].Texto completo external link opens in a new window Resumo external link opens in a new window

893. ClinicalTrials.gov. Anakinra for COVID-19 respiratory symptoms (ANACONDA). 2020 [internet publication].Texto completo external link opens in a new window

894. CORIMUNO-19 Collaborative group. Effect of anakinra versus usual care in adults in hospital with COVID-19 and mild-to-moderate pneumonia (CORIMUNO-ANA-1): a randomised controlled trial. Lancet Respir Med. 2021 Jan 22 [Epub ahead of print].Texto completo external link opens in a new window Resumo external link opens in a new window

895. Celltrion Healthcare. Celltrion’s COVID-19 treatment candidate receives Korean MFDS conditional marketing authorisation. 2021 [internet publication].Texto completo external link opens in a new window

896. Celltrion Healthcare. Celltrion develops tailored neutralising antibody cocktail treatment with CT-P59 to tackle COVID-19 variant spread using its antibody development plat. 2021 [internet publication].Texto completo external link opens in a new window

897. Xie Y, Cao S, Li Q, et al. Effect of regular intravenous immunoglobulin therapy on prognosis of severe pneumonia in patients with COVID-19. J Infect. 2020 Apr 10 [Epub ahead of print].Texto completo external link opens in a new window Resumo external link opens in a new window

898. Zhang J, Yang Y, Yang N, et al. Effectiveness of intravenous immunoglobulin for children with severe COVID-19: a rapid review. Ann Transl Med. 2020 May;8(10):625.Texto completo external link opens in a new window Resumo external link opens in a new window

899. ClinicalTrials.gov. Mesenchymal stem cell treatment for pneumonia patients infected with 2019 novel coronavirus. 2020 [internet publication].Texto completo external link opens in a new window

900. Mesoblast Limited. Mesoblast update on COVID-19 ARDS trial. 2020 [internet publication].Texto completo external link opens in a new window

901. Monk PD, Marsden RJ, Tear VJ, et al. Safety and efficacy of inhaled nebulised interferon beta-1a (SNG001) for treatment of SARS-CoV-2 infection: a randomised, double-blind, placebo-controlled, phase 2 trial. Lancet Respir Med. 2020 Nov 12 [Epub ahead of print].Texto completo external link opens in a new window Resumo external link opens in a new window

902. ClinicalTrials.gov. Interferon lambda for immediate antiviral therapy at diagnosis in COVID-19 (ILIAD). 2020 [internet publication].Texto completo external link opens in a new window

903. Eiger BioPharmaceuticals. Eiger BioPharmaceuticals announces positive results of investigator sponsored randomized controlled trial at University of Toronto with peginterferon lambda in outpatients with mild to moderate COVID-19. 2020 [internet publication].Texto completo external link opens in a new window

904. Grant WB, Lahore H, McDonnell SL, et al. Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths. Nutrients. 2020 Apr 2;12(4).Texto completo external link opens in a new window Resumo external link opens in a new window

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906. Jakovac H. COVID-19 and vitamin D: is there a link and an opportunity for intervention? Am J Physiol Endocrinol Metab. 2020 May 1;318(5):E589.Texto completo external link opens in a new window Resumo external link opens in a new window

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908. National Institute for Health and Care Excellence. COVID-19 rapid guideline: vitamin D. 2020 [internet publication].Texto completo external link opens in a new window

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910. Shah K, Saxena D, Mavalankar D. Vitamin D supplementation, COVID-19 & disease severity: a meta-analysis. QJM. 2021 Jan 24 [Epub ahead of print].Texto completo external link opens in a new window Resumo external link opens in a new window

911. Castillo ME, Entrenas Costa LM, Vaquero Barrios JM, et al. Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: a pilot randomized clinical study. J Steroid Biochem Mol Biol. 2020 Aug 29;105751.Texto completo external link opens in a new window Resumo external link opens in a new window

912. Boretti A, Banik BK. Intravenous vitamin C for reduction of cytokines storm in acute respiratory distress syndrome. PharmaNutrition. 2020 Apr 21:100190.Texto completo external link opens in a new window Resumo external link opens in a new window

913. ClinicalTrials.gov. Vitamin C infusion for the treatment of severe 2019-nCoV infected pneumonia. 2020 [internet publication].Texto completo external link opens in a new window

914. Baladia E, Pizarro AB, Ortiz-Muñoz L, et al. Vitamin C for COVID-19: a living systematic review. Medwave. 2020 Jul 28;20(6):e7978.Texto completo external link opens in a new window Resumo external link opens in a new window

915. Zhang J, Rao X, Li Y; Research Square. Pilot trial of high-dose vitamin C in critically ill COVID-19 patients. 2020 [internet publication].Texto completo external link opens in a new window

916. Reyes AZ, Hu KA, Teperman J, et al. Anti-inflammatory therapy for COVID-19 infection: the case for colchicine. Ann Rheum Dis. 2020 Dec 8 [Epub ahead of print].Texto completo external link opens in a new window Resumo external link opens in a new window

917. Medicines and Healthcare products Regulatory Agency. Colchicine in the management of COVID-19 (SARS-CoV 2) positive patients: trial use only. 2021 [internet publication].Texto completo external link opens in a new window

918. Centre for Evidence-Based Medicine; Ferner RE, Sofat R, Aronson JK. Drug vignettes: colchicine. 2021 [internet publication].Texto completo external link opens in a new window

919. Nuffield Department of Population Health. RECOVERY trial closes recruitment to colchicine treatment for patients hospitalised with COVID-19. 2021 [internet publication].Texto completo external link opens in a new window

920. Hariyanto TI, Halim DA, Jodhinata C, et al. Colchicine treatment can improve outcomes of coronavirus disease 2019 (COVID-19): a systematic review and meta-analysis. Clin Exp Pharmacol Physiol. 2021 Mar 14 [Epub ahead of print].Texto completo external link opens in a new window Resumo external link opens in a new window

921. Medicines and Healthcare products Regulatory Agency. COVID-19 therapeutic alert: antimicrobials (azithromycin and doxycycline) not beneficial in the management of COVID-19 (SARS-CoV-2) positive patients. 2021 [internet publication].Texto completo external link opens in a new window

922. RECOVERY Collaborative Group. Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. Lancet. 2021 Feb 2 [Epub ahead of print].Texto completo external link opens in a new window Resumo external link opens in a new window

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1044. Stewart DJ, Hartley JC, Johnson M, et al. Renal dysfunction in hospitalised children with COVID-19. Lancet Child Adolesc Health. 2020 Jun 15;4(8):e28-9.Texto completo external link opens in a new window Resumo external link opens in a new window

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1046. Nasr SH, Kopp JB. COVID-19-associated collapsing glomerulopathy: an emerging entity. Kidney Int Rep. 2020 May 4;5(6):759-61.Texto completo external link opens in a new window Resumo external link opens in a new window

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1048. Li G, Yang Y, Gao D, et al. Is liver involvement overestimated in COVID-19 patients? A meta-analysis. Int J Med Sci. 2021;18(5):1285-96.Texto completo external link opens in a new window Resumo external link opens in a new window

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1050. Wong GL, Wong VW, Thompson A, et al. Management of patients with liver derangement during the COVID-19 pandemic: an Asia-Pacific position statement. Lancet Gastroenterol Hepatol. 2020 Aug;5(8):776-87.Texto completo external link opens in a new window Resumo external link opens in a new window

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1058. Valencia-Enciso N, Ortiz-Pereira M, Zafra-Sierra MP, et al. Time of stroke onset in coronavirus disease 2019 patients around the globe: a systematic review and analysis. J Stroke Cerebrovasc Dis. 2020 Sep 18;29(12):105325.Texto completo external link opens in a new window Resumo external link opens in a new window

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1060. Qureshi AI, Abd-Allah F, Alsenani F, et al. Management of acute ischemic stroke in patients with COVID-19 infection: report of an international panel. Int J Stroke. 2020 Jul;15(5):540-54.Texto completo external link opens in a new window Resumo external link opens in a new window

1061. Abu-Rumeileh S, Abdelhak A, Foschi M, et al. Guillain-Barré syndrome spectrum associated with COVID-19: an up-to-date systematic review of 73 cases. J Neurol. 2020 Aug 25 [Epub ahead of print].Texto completo external link opens in a new window Resumo external link opens in a new window

1062. Kubota T, Kuroda N. Exacerbation of neurological symptoms and COVID-19 severity in patients with preexisting neurological disorders and COVID-19: a systematic review. Clin Neurol Neurosurg. 2020 Nov 1;106349.Texto completo external link opens in a new window Resumo external link opens in a new window

1063. Lu Y, Li X, Geng D, et al. Cerebral micro-structural changes in COVID-19 patients: an MRI-based 3-month follow-up study. EClinicalMedicine. 2020 Aug;25:100484.Texto completo external link opens in a new window Resumo external link opens in a new window

1064. LaRovere KL, Riggs BJ, Poussaint TY, et al. Neurologic involvement in children and adolescents hospitalized in the United States for COVID-19 or multisystem inflammatory syndrome. JAMA Neurol. 2021 Mar 5 [Epub ahead of print].Texto completo external link opens in a new window Resumo external link opens in a new window

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1072. Ludvigsson JF. Case report and systematic review suggest that children may experience similar long-term effects to adults after clinical COVID-19. Acta Paediatr. 2020 Nov 17 [Epub ahead of print].Texto completo external link opens in a new window Resumo external link opens in a new window

1073. Weng J, Li Y, Li J, et al. Gastrointestinal sequelae 90 days after discharge for COVID-19. Lancet Gastroenterol Hepatol. 2021 Mar 9 [Epub ahead of print].Texto completo external link opens in a new window Resumo external link opens in a new window

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1078. Rodriguez-Morales AJ, Cardona-Ospina JA, Gutiérrez-Ocampo E, et al. Clinical, laboratory and imaging features of COVID-19: a systematic review and meta-analysis. Travel Med Infect Dis. 2020 Mar 13:101623.Texto completo external link opens in a new window Resumo external link opens in a new window

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1081. Connors JM, Levy JH. COVID-19 and its implications for thrombosis and anticoagulation. Blood. 2020 Jun 4;135(23):2033-40.Texto completo external link opens in a new window Resumo external link opens in a new window

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1089. Pain CE, Felsenstein S, Cleary G, et al. Novel paediatric presentation of COVID-19 with ARDS and cytokine storm syndrome without respiratory symptoms. Lancet Rheumatol. 2020 May 15;2(7):e376-9.Texto completo external link opens in a new window Resumo external link opens in a new window

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1143. Wongvibulsin S, Garibaldi BT, Antar AAR, et al. Development of severe COVID-19 adaptive risk predictor (SCARP), a calculator to predict severe disease or death in hospitalized patients with COVID-19. Ann Intern Med. 2021 Mar 2 [Epub ahead of print].Texto completo external link opens in a new window Resumo external link opens in a new window

1144. Chua F, Vancheeswaran R, Draper A, et al. Early prognostication of COVID-19 to guide hospitalisation versus outpatient monitoring using a point-of-test risk prediction score. Thorax. 2021 Mar 10 [Epub ahead of print].Texto completo external link opens in a new window Resumo external link opens in a new window

1145. Yadaw AS, Li YC, Bose S, et al. Clinical features of COVID-19 mortality: development and validation of a clinical prediction model. Lancet Digit Health. 2020 Oct;2(10):e516-25.Texto completo external link opens in a new window Resumo external link opens in a new window

1146. Knight SR, Ho A, Pius R, et al. Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO clinical characterisation protocol: development and validation of the 4C mortality score. BMJ. 2020 Sep 9;370:m3339.Texto completo external link opens in a new window Resumo external link opens in a new window

1147. Centers for Disease Control and Prevention. Interim guidance for public health professionals managing people with COVID-19 in home care and isolation who have pets or other animals. 2020 [internet publication].Texto completo external link opens in a new window

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1149. Shi J, Wen Z, Zhong G, et al. Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS-coronavirus 2. Science. 2020 May 29;368(6494):1016-20.Texto completo external link opens in a new window Resumo external link opens in a new window

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1151. Newman A, Smith D, Ghai RR, et al. First reported cases of SARS-CoV-2 infection in companion animals: New York, March-April 2020. MMWR Morb Mortal Wkly Rep. 2020 Jun 12;69(23):710-3.Texto completo external link opens in a new window Resumo external link opens in a new window

1152. Halfmann PJ, Hatta M, Chiba S, et al. Transmission of SARS-CoV-2 in domestic cats. N Engl J Med. 2020 Aug 6 [Epub ahead of print].Texto completo external link opens in a new window Resumo external link opens in a new window

1153. San Diego Zoo Global. Gorilla troop at the San Diego Zoo Safari Park test positive for COVID-19. 2021 [internet publication].Texto completo external link opens in a new window

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