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Cochrane Clinical Answers (CCAs) provide a readable, digestible, clinically focused entry point to rigorous research from Cochrane systematic reviews. They are designed to be actionable and to inform decision making at the point of care and have been added to relevant sections of the main Best Practice text.

  • In people with chronic obstructive pulmonary disease, what are the effects of integrated disease management interventions?
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  • How does umeclidinium bromide compare with placebo for people with chronic obstructive pulmonary disease (COPD)?
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  • How does long-acting muscarinic antagonist (LAMA) plus long-acting beta-agonist (LABA) compare with LABA plus inhaled corticosteroid (ICS) for people with stable chronic obstructive pulmonary disease (COPD)?
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  • How does tiotropium compare with ipratropium bromide for people with chronic obstructive pulmonary disease (COPD)?
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  • How does a combined inhaler with once‐daily long‐acting beta2‐agonist (LABA) plus a long‐acting muscarinic antagonist (LAMA) compare with placebo for adults with chronic obstructive pulmonary disease (COPD)?
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  • What are the longer-term (>6 months) effects of inhaled corticosteroids in people with stable chronic obstructive pulmonary disease?
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  • What are the effects of long‐acting inhaled therapies for adults with chronic obstructive pulmonary disease (COPD)?
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  • In people with chronic obstructive pulmonary disease (COPD), what are the effects of combined corticosteroid and long-acting beta-agonist (LABA) in one inhaler versus LABA alone?
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  • What are the effects of prophylactic antibiotics for people with chronic obstructive pulmonary disease (COPD)?
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  • What are the effects of influenza vaccine in people with chronic obstructive pulmonary disease (COPD)?
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  • For people with chronic bronchitis or chronic obstructive pulmonary disease, how do mucolytic agents compare with placebo?
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  • What are the effects of pulmonary rehabilitation after exacerbation in people with chronic obstructive pulmonary disease?
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  • How does bronchoscopic lung volume reduction compare with medical therapy in people with chronic obstructive pulmonary disease?
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  • How does combined aclidinium/formoterol compare with aclidinium or formoterol monotherapy for people with chronic obstructive pulmonary disease (COPD)?
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  • How does lung volume reduction surgery compare with usual medical care in people with diffuse emphysema?
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