Resumo
Definição
História e exame físico
Principais fatores diagnósticos
- presença de fatores de risco
- exposição ao vírus Ebola nos últimos 21 dias
- febre
- mialgia
- hiperemia conjuntival
Outros fatores diagnósticos
- fadiga
- anorexia
- diarreia
- vômitos
- cefaleia intensa
- dor abdominal ou pirose
- tosse, dispneia, dor torácica
- faringite
- prostração
- taquipneia
- exantema maculopapular
- sangramento
- hepatomegalia
- linfadenopatia
- soluços
- taquicardia
- hipotensão
- sinais neurológicos
Fatores de risco
- morar, trabalhar ou chegar de uma área endêmica nos últimos 21 dias
- contato com fluidos corporais infectados
- exposição ocupacional
- hábito de comer carne de caça ou consumo de carne de animais infectados (ou potencialmente infectados)
- bioterrorismo
Investigações diagnósticas
Primeiras investigações a serem solicitadas
- reação em cadeia da polimerase via transcriptase reversa (RT-PCR)
- investigações para malária
Investigações a serem consideradas
- níveis de eletrólitos séricos
- creatinina sérica e ureia
- lactato sanguíneo
- gasometria arterial
- Hemograma completo
- exames de coagulação
- urinálise
- TFHs
- nível de amilase sérica
- glicemia sérica
- hemoculturas
- ELISA de captura de antígeno
- anticorpos do tipo imunoglobulina G (IgG) e imunoglobulina M (IgM)
- radiografia torácica
Algoritmo de tratamento
Colaboradores
Autores
Catherine F. Houlihan, MSc, MB ChB, MRCP, DTM&H
Clinical Lecturer
University College London
Honorary Clinical Lecturer
London School of Hygiene and Tropical Medicine
London
UK
Declarações
CFH has been on a scientific advisory board for Valneva regarding Chikungunya vaccines.
Manuel Fenech, MD, MRCP, DTM&H
Specialist Trainee in Infectious Diseases
Royal Liverpool University Hospital
Liverpool
UK
Declarações
MF declares that he has no competing interests.
Tom E. Fletcher, MBE, MBChB, MRCP, DTM&H
Wellcome Trust/MoD Research Fellow
Liverpool School of Tropical Medicine
Liverpool
UK
Declarações
TEF is an author of a number of references cited in this monograph. TEF is a consultant/expert panel member to the World Health Organization, and is funded by the UK Surgeon General and the Wellcome Trust. TEF has received research grants from the Medical Research Council and the UK Public Health Rapid Support Team (UK-PHRST).
Agradecimentos
Dr Catherine F. Houlihan, Dr Manuel Fenech, and Dr Tom E. Fletcher would like to thank Dr Nicholas J. Beeching, a previous contributor to this topic, and Dr Colin Brown (Infectious Disease Lead, Kings Sierra Leone Partnership) for his helpful comments and insights.
Declarações
NJB was partially supported by the National Institute of Health Research Health Protection Unit in Emerging and Zoonotic Infections at the University of Liverpool and Public Health England. NJB is an author of references cited in this topic. CB declares that he has no competing interests.
Revisores
William A. Petri, Jr, MD, PhD, FACP
Wade Hampton Frost Professor of Epidemiology
Professor of Medicine, Microbiology, and Pathology
Chief
Division of Infectious Diseases and International Health
University of Virginia
Charlottesville
VA
Declarações
WAP declares that he has no competing interests.
Luis Ostrosky-Zeichner, MD, FACP, FIDSA, FSHEA
Professor of Medicine and Epidemiology
UT Health Medical School
Medical Director of Epidemiology
Memorial Hermann Texas Medical Center
Houston
TX
Declarações
LO-Z declares that he has no competing interests.
Stephen Mepham, MRCP (UK), FRCPATH, DTM&H, MD
Consultant in Microbiology and Infectious Diseases
Royal Free London NHS Foundation Trust
London
UK
Declarações
SM declares that he has no competing interests.
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