Cases have been reported across all continents since the beginning of the pandemic. Over 600 million confirmed cases and over 6.5 million deaths have been reported globally.
Updated case counts are available from the World Health Organization (WHO) and the Centers for Disease Control and Prevention (CDC):
Data from the CDC between February 2020 to September 2021 indicate the following estimated rates of disease outcomes in the US:
Infection: 44,650 per 1000,000 (44.6%)
Symptomatic illness: 37,764 per 100,000 (37.8%)
Hospitalization: 2286 per 100,000 (2.3%)
Death: 281 per 100,000 (0.28%).
Older people ≥70 years of age and males are at increased risk for infection and severe disease. Adolescents appear to have similar susceptibility to infection as adults, and children have a lower susceptibility. However, evidence is conflicting and the detailed relationship between age and susceptibility to infection requires further investigation. Unlike adults, children do not seem to be at higher risk for severe disease based on age or sex. Variants may spread more effectively and rapidly among young children compared with the wild-type virus, although hospitalization rates decreased.
The incidence of infection in healthcare workers ranged from 0% to 49.6%, and the prevalence of seropositivity ranged from 1.6% to 31.6%. There was no association between age, sex, or healthcare worker role (i.e., nurse versus physician) and the risk for infection, based on moderate-certainty evidence. There was an association between Black race or Hispanic ethnicity and increased risk for infection compared with White race or non-Hispanic ethnicity, based on moderate-certainty evidence. There was an association between use of personal protective equipment and decreased risk for infection, based on moderate-certainty evidence.
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