Criteria

World Health Organization: COVID-19 disease severity[85]

Mild illness

  • Symptomatic patients meeting the case definition for COVID-19 without evidence of hypoxia or pneumonia.

  • Common symptoms include fever, cough, fatigue, anorexia, dyspnea, and myalgia. Other nonspecific symptoms include sore throat, nasal congestion, headache, diarrhea, nausea/vomiting, and loss of smell/taste. Additional neurologic manifestations reported include dizziness, agitation, weakness, seizures, or findings suggestive of stroke. Children may not report fever or cough as frequently as adults.

  • Older people and immunosuppressed people may present with atypical symptoms (e.g., fatigue, reduced alertness, reduced mobility, diarrhea, loss of appetite, delirium, absence of fever).

  • Symptoms due to physiologic adaptations of pregnancy or adverse pregnancy events (e.g., dyspnea, fever, gastrointestinal symptoms, fatigue) or other diseases (e.g., malaria) may overlap with COVID-19 symptoms.

Moderate disease

  • Adolescent or adult: clinical signs of pneumonia (i.e., fever, cough, dyspnea, fast breathing) but no signs of severe pneumonia, including blood oxygen saturation levels (SpO₂) ≥90% on room air.

  • Children: clinical signs of nonsevere pneumonia (i.e., cough or difficulty breathing plus fast breathing and/or chest indrawing) and no signs of severe pneumonia. Fast breathing is defined as:

    • <2 months of age: ≥60 breaths/minute

    • 2-11 months of age: ≥50 breaths/minute

    • 1-5 years years of age: ≥40 breaths/minute.

  • While the diagnosis can be made on clinical grounds, chest imaging may assist in diagnosis and identify or exclude pulmonary complications.

Severe disease

  • Adolescent or adult: clinical signs of pneumonia (i.e., fever, cough, dyspnea, fast breathing) plus one of the following:

    • Respiratory rate >30 breaths/minute

    • Severe respiratory distress

    • SpO₂ <90% on room air.

  • Children: clinical signs of pneumonia (i.e., cough or difficulty in breathing) plus at least one of the following:

    • Central cyanosis or SpO₂ <90%

    • Severe respiratory distress (e.g., fast breathing, grunting, very severe chest indrawing)

    • General danger signs: inability to breastfeed or drink, lethargy or unconsciousness, or convulsions

    • Fast breathing (<2 months: ≥60 breaths per minute; 2-11 months: ≥50 breaths per minute; 1-5 years: ≥40 breaths per minute).

  • While the diagnosis can be made on clinical grounds, chest imaging may assist in diagnosis and identify or exclude pulmonary complications.

Critical disease

  • Presence of acute respiratory distress syndrome (ARDS), sepsis, septic shock, acute thrombosis, or multisystem inflammatory syndrome in children.

World Health Organization: hospitalization risk for patients with nonsevere disease[402]

Several recommendations for people with nonsevere disease, specifically for the use of antiviral drugs (i.e., nirmatrelvir/ritonavir, molnupiravir, remdesivir), are stratified by the likelihood of hospital admission. The criteria for deciding whether a patient is at high, moderate, or low risk of hospitalization are detailed below.

  • High risk (6%) of hospitalization

    • Diagnosed immunodeficiency syndromes.

    • History of solid organ transplant and receiving immunosuppressants.

    • Autoimmune illness and receiving immunosuppressants.

  • Moderate risk (3%) of hospitalization

    • Age ≥65 years.

    • Obesity.

    • Diabetes and/or chronic cardiopulmonary disease.

    • Chronic kidney or liver disease.

    • Active cancer.

    • Disabilities.

    • Comorbidities of chronic disease.

  • Low risk (0.5%) of hospitalization

    • Not at moderate or high risk of hospitalization (most patients are low risk).

Infectious Diseases Society of America: disease severity definitions[398]

Mild-to-moderate illness

  • Patients with a SpO₂ >94% not requiring supplemental oxygen.

Severe illness

  • Patients with SpO₂ ≤94% on room air, including patients on supplemental oxygen.

Critical illness

  • Patients on mechanical ventilation and extracorporeal mechanical oxygenation (ECMO).

  • Includes end-organ dysfunction as is seen in sepsis/septic shock. The most commonly reported form of end-organ dysfunction is acute respiratory distress syndrome (ARDS).

Case definitions

Various case definitions are available:

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