是一种 B 淋巴细胞肿瘤。由于 B 淋巴细胞无法发育成熟和完成分化,会出现功能异常但能自我更新的单克隆 B 淋巴细胞,这些淋巴细胞能浸润淋巴组织和造血器官比如肝、脾和骨髓。一个关键的危险因素是年龄超过 60 岁。淋巴结病、脾大(见于 50% 的病例)、呼吸急促以及疲乏是关键诊断因素。[4]Hallek M. State-of-the-art treatment of chronic lymphocytic leukemia. Hematology Am Soc Hematol Educ Program. 2009:440-449.
http://asheducationbook.hematologylibrary.org/content/2009/1/440.long
http://www.ncbi.nlm.nih.gov/pubmed/20008230?tool=bestpractice.com
[5]Hallek M, Cheson BD, Catovsky D, et al. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia (IWCLL) updating the National Cancer Institute-Working Group (NCI-WG) 1996 guidelines. Blood. 2008;111:5446-5456.
http://bloodjournal.hematologylibrary.org/content/111/12/5446.full
http://www.ncbi.nlm.nih.gov/pubmed/18216293?tool=bestpractice.com
[6]Eichhorst B, Robak T, Montserrat E, et al. Chronic lymphocytic leukaemia: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2015;26(suppl 5):78-84.
http://annonc.oxfordjournals.org/content/22/suppl_6/vi50.long
http://www.ncbi.nlm.nih.gov/pubmed/26314781?tool=bestpractice.com
该病通过全血细胞计数(full blood count, FBC)及分类计数、血涂片显示涂抹细胞以及流式细胞术进行诊断。[4]Hallek M. State-of-the-art treatment of chronic lymphocytic leukemia. Hematology Am Soc Hematol Educ Program. 2009:440-449.
http://asheducationbook.hematologylibrary.org/content/2009/1/440.long
http://www.ncbi.nlm.nih.gov/pubmed/20008230?tool=bestpractice.com
[5]Hallek M, Cheson BD, Catovsky D, et al. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia (IWCLL) updating the National Cancer Institute-Working Group (NCI-WG) 1996 guidelines. Blood. 2008;111:5446-5456.
http://bloodjournal.hematologylibrary.org/content/111/12/5446.full
http://www.ncbi.nlm.nih.gov/pubmed/18216293?tool=bestpractice.com
[6]Eichhorst B, Robak T, Montserrat E, et al. Chronic lymphocytic leukaemia: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2015;26(suppl 5):78-84.
http://annonc.oxfordjournals.org/content/22/suppl_6/vi50.long
http://www.ncbi.nlm.nih.gov/pubmed/26314781?tool=bestpractice.com
大多数患者均在针对非相关原因进行常规 FBC 检查后得到诊断。