Evaluation of pancytopenia
Summary
Diagnósticos diferenciais
comuns
- Chemotherapy
- Radiation therapy
- Vitamin B12 deficiency
- Folic acid deficiency
- Bone marrow infiltration by nonhematologic malignancy
- Non-Hodgkin lymphoma
- Hairy cell leukemia
- Chronic lymphocytic leukemia
- Myelodysplasia
- Cirrhosis
- Hepatitis B
- Hepatitis C
- Autoimmune hepatitis
- HIV
- Cytomegalovirus infection
- Mycobacterial infection
Incomuns
- Acute myeloid leukemia
- Acute lymphoblastic leukemia (ALL)
- Multiple myeloma
- Myelofibrosis
- Lysosomal storage disorders
- Anorexia nervosa
- Graft-versus-host disease (GVHD)
- Heavy metal (arsenic) poisoning
- Parvovirus infection in sickle cell anemia (and other hemolytic anemias)
- Dyskeratosis congenita (DC)
- Paroxysmal nocturnal hemoglobinuria (PNH)
- Idiopathic aplastic anemia
- Fanconi anemia
- Other rare inherited cytopenias (e.g., Diamond Blackfan anemia, Shwachman Diamond syndrome, amegakaryocytic thrombocytopenia)
- Idiopathic portal hypertension
- Chronic myeloid leukemia
- Brucellosis
- Leishmaniasis
- Hemophagocytosis syndromes
- Drug-induced immune pancytopenia
- Evans syndrome with associated neutropenia
- Autoimmune lymphoproliferative syndrome (ALPS)
- Systemic lupus erythematosus
- Rheumatoid arthritis
- Infectious mononucleosis
- Felty syndrome
Colaboradores
Autores
Jeffrey M. Lipton, MD, PhD
Frances and Thomas Gambino Professor of Pediatrics in Hematology/Oncology
Professor of Pediatrics and Molecular Medicine
Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
Professor, The Center for Autoimmune Musculoskeletal and Hematopoietic Diseases
Feinstein Institute for Medical Research
Director, Hematology/Oncology and Stem Cell Transplantation
Cohen Children's Medical Center of New York
Hyde Park
New York
Declarações
JML has been reimbursed by Chiesi Farmaceutici S.p.A as a consultant.
Agradecimentos
Dr Jeffrey M. Lipton would like to gratefully acknowledge Dr Jeff K. Davies and Dr Eva C. Guinan, the previous contributors to this topic.
Declarações
JKD and ECG declare that they have no competing interests.
Revisores
Stella Davies, MD, PhD
Professor and Division Director
Cincinnati Children's Hospital Medical Center
Cincinnati
OH
Declarações
SD declares that she has no competing interests.
Drew Provan, BSc, MBChB
Consultant Hematologist
Department of Hematology
The Royal London Hospital
London
UK
Declarações
DP was medical director at GlaxoSmithKline 2005-2006.
Alfred P. Gillio, MD
Director
Bone Marrow Failure Clinic
Tomorrows Children's Institute
Hackensack University Medical Center
Hackensack
NJ
Declarações
APG declares that he has no competing interests.
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Referências
Principais artigos
Kulasekararaj A, Cavenagh J, Dokal I, et al. Guidelines for the diagnosis and management of adult aplastic anaemia: a British Society for Haematology guideline. Br J Haematol. 2024 Mar;204(3):784-804.Texto completo Resumo
Young NS. Aplastic anemia. N Engl J Med. 2018 Oct 25;379(17):1643-56.Texto completo Resumo
Williams DA, Bennett C, Bertuch A, et al. Diagnosis and treatment of pediatric acquired aplastic anemia (AAA): an initial survey of the North American Pediatric Aplastic Anemia Consortium (NAPAAC). Pediatr Blood Cancer. 2014 May;61(5):869-74.Texto completo Resumo
Khoury JD, Solary E, Abla O, et al. The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: myeloid and histiocytic/dendritic neoplasms. Leukemia. 2022 Jul;36(7):1703-19.Texto completo Resumo
Artigos de referência
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