慢性髓系白血病

最后审阅: 28 十月 2022
最后更新: 21 四月 2022

小结

定义

病史和体格检查

关键诊断因素

  • 存在的危险因素
  • 脾肿大
  • 呼吸短促
  • 左上腹不适或饱胀感
  • 鼻衄
  • 关节痛
  • 胸骨压痛
更多 关键诊断因素

其他诊断因素

  • 体重减轻
  • 多汗
  • 发热
  • 苍白
  • 青肿
  • 视网膜出血
其他诊断因素

危险因素

  • 年龄 65~74 岁
  • 电离辐射暴露
  • 男性
更多 危险因素

诊断性检查

首要检查

  • 全血细胞计数 (FBC)
  • 全部代谢检测
  • 外周血涂片
  • 骨髓活检
  • 细胞遗传学检查
  • 包括断裂点分析的定量逆转录PCR(qRT-PCR)
  • 荧光原位杂交 (FISH)
更多 首要检查

治疗流程

急症处理

慢性期

加速期

急变期

持续性治疗

异基因造血干细胞移植后复发,或存在异基因造血干细胞移植禁忌证

撰稿人

作者

Michael J. Mauro, MD

Leader, Myeloproliferative Neoplasms Program, Leukemia Service

Attending Physician and Member

Memorial Sloan Kettering Cancer Center

Professor, Weill Cornell Medicine

NY

利益声明

MJM has received institutional research support for clinical trials from Novartis, Bristol Myers Squibb, Takeda, and Sun Pharma/Sparc, and honoraria for consulting/advisory boards from Novartis, Bristol Myers Squibb, Takeda, and Pfizer.

鸣谢

Dr Michael Mauro would like to gratefully acknowledge Dr Tim Somervaille, Dr Han Myint, and Dr Robert Chen, the previous contributors to this topic.

利益声明

TS has received travel support and speaker expenses from Novartis, and has served as a consultant to Novartis for development of drugs for indications other than CML. HM sits on the advisory board of Novartis and Bristol-Myers Squibb, and also does speaking engagements on their behalf. RC declares that he has no competing interests.

同行评议者

Rebecca Connor, MD

Chief Fellow

Section of Hematology and Oncology

Department of Internal Medicine

Wake Forest University Baptist Medical Center

Winston-Salem

NC

利益声明

RC declares that she has no competing interests.

Richard E. Clark, MA, MD, FRCP, FRCPath

Professor of Haematology

Royal Liverpool University Hospital

Liverpool

UK

利益声明

None disclosed.

内容使用需遵循免责声明