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毛细胞白血病

最后审阅: 3 Sep 2024
最后更新: 22 Aug 2023

小结

定义

病史和体格检查

关键诊断因素

  • 存在的危险因素
  • 腹胀或腹部不适
  • 脾肿大
完整详情

其他诊断因素

  • 虚弱和疲乏
  • 原因不明的体重下降
  • 瘀血和出血
  • 苍白和出血点
  • 发热
  • 复发性感染
  • 肝肿大
  • 浅表和深部淋巴结肿大
  • 神经系统异常
  • 相关系统性免疫疾病
完整详情

危险因素

  • 中年
  • 男性
  • 白人血统
  • 西半球的位置
  • 环境暴露
  • 遗传易感性
  • EB病毒
  • 传染性单核细胞增多症
完整详情

诊断性检查

首要检查

  • 全血细胞计数 (FBC)
  • 外周血涂片
  • 骨髓环钻活检和抽吸(形态学评估)
  • 免疫组织化学检查
完整详情

需考虑的检查

  • 流式细胞仪
  • 分子分析(用于识别 BRAF V600E 突变或 IGHV4-34 重排)
  • 腹部 CT
完整详情

治疗流程

急症处理

有症状的:无脾破裂或巨脾或显著的非化疗引起的血小板减少

有症状的:有脾破裂或巨脾或显著的非化疗引起的血小板减少

持续性治疗

无症状性疾病或治疗后微小残留病

撰稿人

作者

Ambuj Kumar, MD, MPH

Professor

USF Health Office of Research

Department of Internal Medicine, College of Medicine

Moffitt Cancer Center & Research Institute, Department of Health Outcomes & Behavior

University of South Florida

Tampa

FL

利益声明

AK declares that he has no competing interests.

Mohamed A. Kharfan-Dabaja, MD, MBA, FACP

Professor

Division of Hematology-Oncology

Blood and Marrow Transplantation Program

Mayo Clinic

Jacksonville

FL

利益声明

MKD declares that he has no competing interests.

鸣谢

Dr Ambuj Kumar and Dr Mohamed Kharfan-Dabaja would like to gratefully acknowledge Dr Benjamin Djulbegovic, a previous contributor to this topic.

利益声明

BD declares that he has no competing interests.

同行评议者

Daniel Catovsky, MD, FRCP, FRCPath, DSc, FMedSc

Consultant Haemato-Oncologist

Section of Haemato-Oncology

Brookes Lawley Institute of Cancer

Sutton

UK

利益声明

DC declares that he has no competing interests.

Roger Lyons, MD

Clinical Professor of Medicine

University of Texas Health Science Center San Antonio

San Antonio

TX

利益声明

RL declares that he has no competing interests.

Rebecca Connor, MD

Chief Fellow

Section of Hematology and Oncology

Department of Internal Medicine

Wake Forest University Baptist Medical Center

Winston-Salem

NC

利益声明

RC declares that she has no competing interests.

Claire Dearden, BSc, MD, FRCP, FRCPath

Consultant Haematologist

The Royal Marsden Hospital

Sutton

Surrey

UK

利益声明

CD declares that she has no competing interests.

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