小结
定义
病史和体格检查
关键诊断因素
- 呼吸短促和疲乏
- 淋巴结肿大
- 脾肿大
- 肝肿大
其他诊断因素
- 存在的危险因素
- B 症状
- 复发性感染
- 瘀斑
危险因素
- 60 岁以上
- 男性
- 白种人
- CLL 家族史
诊断性检查
首要检查
- 白细胞分类计数
- 血涂片
- 血红蛋白
- 血小板计数
- 流式细胞仪
需考虑的检查
- 荧光原位杂交 (FISH)
- 分子遗传学检测分析
- 直接抗人球蛋白试验 (DAT)
- 免疫球蛋白水平
- 骨髓穿刺和环钻活检
- CT 扫描
治疗流程
无症状早期（Binet 分期 A 期和 B 期；Rai 分期 0-Ⅱ 期）
晚期 (Binet C；Rai III-IV) 或症状性疾病
复发或难治性疾病
撰稿人
作者
Jacqueline C. Barrientos, MD, MS
Associate Professor
Department of Medicine
Zucker School of Medicine at Hofstra/Northwell
CLL Research & Treatment Program
Northwell Health Cancer Institute
Lake Success
NY
利益声明
JCB has been a consultant for Beigene, Abbvie, and AstraZeneca; received honoraria from Janssen; and received research funding from Oncternal, VelosBio, and Pharmacyclics.
Joanna M. Rhodes, MD, MSCE
Assistant Professor
Department of Medicine
Zucker School of Medicine at Hofstra/Northwell
CLL Research and Treatment Program
Northwell Health Cancer Institute
Lake Success
NY
利益声明
JMR has been a consultant for Abbvie, Genentech, Pharmacyclics, AstraZeneca, Beigene, Verastem, TG Therapeutics, Jannsen, and SeaGen.
鸣谢
Dr Jacqueline C. Barrientos and Dr Joanna M. Rhodes would like to gratefully acknowledge Dr Vidhya Murthy, Dr Shankaranarayana Paneesha, and Dr Robert Chen, previous contributors to this topic.
利益声明
VM has received a consultancy fee from Janssen, and a grant from Takeda for the ASH Annual Meeting 2014. SP has received consultancy and speaker fees from Janssen, Gilead, AbbVie, Bristol-Myers Squibb, and Takeda. RC declares that he has no competing interests.
同行评议者
Daniel Catovsky, MD, FRCP, FRCPath, DSc, FMedSc
Consultant Haemato-oncologist
Section of Haemato-Oncology
The Institute of Cancer Research
Sutton
UK
利益声明
DC declares that he has no competing interests.
Paolo F. Caimi, MD
Associate Professor
Department of Medicine
Case Western Reserve University
Case Comprehensive Cancer Center
Cleveland
OH
利益声明
PFC has received honoraria from Celgene for participation in a speaker bureau, and from Kite Pharma for participation in an advisory board.
鉴别诊断
- 淋巴瘤的白血病阶段
更多 鉴别诊断指南
- 慢性淋巴细胞白血病的治疗指南
- 造血细胞移植（HCT）
更多 指南患者教育信息
白血病（慢性淋巴细胞性）
更多 患者教育信息
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