小结
定义
病史和体格检查
关键诊断因素
- 呼吸短促和疲乏
- 淋巴结肿大
- 脾肿大
- 肝肿大
其他诊断因素
- 存在的危险因素
- B 症状
- 复发性感染
- 瘀斑
危险因素
- 60 岁以上
- 男性
- 白种人
- CLL 家族史
诊断性检查
首要检查
- 白细胞分类计数
- 血涂片
- 血红蛋白
- 血小板计数
- 流式细胞仪
需考虑的检查
- 荧光原位杂交 (FISH)
- 分子遗传学检测分析
- 直接抗人球蛋白试验 (DAT)
- 免疫球蛋白水平
- 骨髓穿刺和环钻活检
- CT 扫描
治疗流程
无症状早期（Binet A 和 B；Rai 0-II）
晚期 (Binet C；Rai III-IV) 或症状性疾病
晚期复发
早期复发或难治性疾病
撰稿人
作者
Vidhya Murthy, MBBS, MRCP, FRCPath
Consultant Haematologist
Department of Haematology & Stem Cell Transplantation
Birmingham Heartlands Hospital
Birmingham
UK
利益声明
VM declares that she received a consultancy fee from Janssen, and a grant from Takeda for the ASH Annual Meeting 2014.
Shankaranarayana Paneesha, MD, FRCP, FRCPath
Consultant Haematologist
Department of Haematology & Stem Cell Transplantation
Birmingham Heartlands Hospital
Birmingham
UK
利益声明
SP declares that he has received consultancy and speaker fees from Janssen, Gilead, AbbVie, Bristol-Myers Squibb, and Takeda.
鸣谢
Dr Vidhya Murthy and Dr Shankaranarayana Paneesha would like to gratefully acknowledge Dr Robert Chen, a previous contributor to this monograph.
利益声明
RC declares that he has no competing interests.
同行评议者
Daniel Catovsky, MD, FRCP, FRCPath, DSc, FMedSc
Consultant Haemato-oncologist
Section of Haemato-Oncology
The Institute of Cancer Research
Sutton
UK
利益声明
DC declares that he has no competing interests.
Paolo F. Caimi, MD
Associate Professor
Department of Medicine
Case Western Reserve University
Case Comprehensive Cancer Center
Cleveland
OH
利益声明
PFC has received honoraria from Celgene for participation in a speaker bureau, and from Kite Pharma for participation in an advisory board.
鉴别诊断
- 淋巴瘤的白血病阶段
更多 鉴别诊断指南
- 疑似癌症：识别和转诊
- 慢性淋巴细胞白血病/小淋巴细胞性淋巴瘤
更多 指南患者教育信息
白血病（慢性淋巴细胞性）
更多 患者教育信息
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