For updates on diagnosis and management of coexisting conditions during the coronavirus disease 2019 (COVID-19) pandemic, see our topic "Management of coexisting conditions in the context of COVID-19".
COPD has an insidious onset and usually presents in older people. A history of productive cough, wheezing, and shortness of breath, particularly with exercise, is typical. Other symptoms include frequent bronchitis, reduced exercise tolerance, waking at night with breathlessness, ankle swelling, and fatigue.
Patients may complain of fatigue as a result of disrupted sleep secondary to constant nocturnal cough and persistent hypoxia and hypercapnia. The patient's smoking history, occupational exposures, comorbidities, and any family history of lung disease should be determined. A history of previous exacerbations and hospitalizations should be sought.
Patients with COPD may also present with acute, severe shortness of breath, fever, and chest pain during acute infectious exacerbation. See our topic on "Acute exacerbation of chronic obstructive pulmonary disease" for further information.
Although spirometry is required to make the diagnosis, a physical exam is an important part of patient care. Examination may show tachypnea, respiratory distress, use of accessory muscles, and intercostal retraction. Barrel chest is a common observation. There may be hyperresonance on percussion, and distant breath sounds and poor air movement on auscultation. Wheezing, coarse crackles, clubbing, and cyanosis, as well as signs of right-side heart failure (distended neck veins, loud P2, hepatomegaly, hepatojugular reflux, and lower-extremity edema), may be present. Occasionally patients may exhibit asterixis - loss of postural control in the outstretched arms (commonly known as a flap) caused by hypercapnia. This is due to impaired gas exchange in lung parenchyma, worsens with exercise, and is suggestive of respiratory failure.
Early inspiratory crackles
Spirometry is required to make the diagnosis of COPD and is also used for monitoring disease progress. It is the most reproducible and objective measure of airflow limitation. Spirometry should be performed after administering an adequate dose of at least one short-acting inhaled bronchodilator to minimize variability. Patients with COPD have a distinctive pattern seen on spirometry, with a reduced FEV1 and FEV1/FVC ratio. The presence of airflow limitation is defined by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria as a postbronchodilator FEV1/FVC <0.70. In cases where FVC may be hard to measure, FEV6 (forced expiratory volume at 6 seconds) can be used. Spirometry also indicates the severity of airflow obstruction. In patients with an FEV1/FVC ratio <0.7:
FEV1 ≥80% predicted indicates mild COPD
FEV1 <80% and ≥50% predicted indicates moderate COPD
FEV1 <50% and ≥30% predicted indicates severe COPD
FEV1 <30% predicted indicates very severe COPD.
Spirometry in practice
Spirometry technique and interpretation
Chest x-ray (CXR) is rarely diagnostic but should be performed to exclude other diagnoses. Pulse oximetry screens for hypoxia.
In addition to airflow limitation, the GOLD guidelines recognize the importance of exacerbations in affecting the natural course of COPD, and place emphasis on assessment of symptoms, risk factors for exacerbations, and comorbidities.
The Modified British Medical Research Council (mMRC) questionnaire or the COPD Assessment Test (CAT) are recommended to assess symptoms. These can be found in the GOLD guidelines. GOLD cautions against the use of the mMRC dyspnea scale alone for assessing patients, as symptoms of COPD go beyond dyspnea alone. For this reason, the CAT is preferred. However, GOLD acknowledges that the use of the mMRC scale is widespread, and so a threshold of an mMRC grade ≥2 is still included to define "more breathless" patients, as opposed to "less breathless" patients, in its assessment criteria.
The best predictor of frequent exacerbations (two or more per year) is a history of previously treated exacerbations. In addition, the risk of exacerbations is significantly higher in patients with airflow limitation <50% (severe or very severe COPD).
The GOLD guideline uses a combined COPD assessment approach to group patients according to symptoms and previous history of exacerbations. Symptoms are assessed using the mMRC or CAT scale.
Group A: low risk (0-1 exacerbation per year, not requiring hospitalization) and fewer symptoms (mMRC 0-1 or CAT <10)
Group B: low risk (0-1 exacerbation per year, not requiring hospitalization) and more symptoms (mMRC ≥2 or CAT≥ 10)
Group C: high risk (≥2 exacerbations per year, or one or more requiring hospitalization) and fewer symptoms (mMRC 0-1 or CAT <10)
Group D: high risk (≥2 exacerbations per year, or one or more requiring hospitalization) and more symptoms (mMRC ≥ 2 or CAT≥ 10).
UK guidelines recommend a complete blood count (CBC) for all newly diagnosed patients to screen for anemia or polycythemia.
Detailed pulmonary function tests performed in specialist pulmonary function laboratories can measure flow volume loops and inspiratory capacity. They are not used routinely but can be helpful in resolving diagnostic uncertainties and for preoperative assessment. Diffusing capacity of the lung for carbon monoxide (DLCO) was previously only measured in specialist laboratories; however, portable systems are now available, allowing measurements to be taken in the field. International guidelines from GOLD recommend a DLCO measurement if a patient with COPD has dyspnea that is disproportionate to their degree of airflow obstruction. A low DLCO value (<60% predicted) in a patient with COPD is associated with decreased exercise capacity, worse health status, and increased risk of death. Serial peak flow measurements may distinguish COPD from asthma if there is diagnostic uncertainty.
In young patients (<45 years) with a family history or with rapidly progressing disease and lower lobe changes on imaging tests, alpha-1 antitrypsin level should be checked. The World Health Organization recommends that all patients with a diagnosis of COPD should be screened once, especially in areas with high prevalence of alpha-1 antitrypsin deficiency. This may aid in family screening and counseling.
Computed tomography scans show anatomic changes, but their usefulness in diagnosis is confined to patients considered for surgery and for ruling out other pathologies, such as bronchiectasis or lung cancer. Annual low-dose CT scan (LDCT) is recommended by the US Preventive Services Task Force (USPSTF) for lung cancer screening in patients with COPD that is due to smoking.
Pulse oximetry should be used to assess all patients with clinical signs of respiratory failure or right heart failure. If peripheral arterial oxygen saturation is less than 92%, then arterial or capillary blood gases should be measured.
Obstructive sleep apnea is associated with increased risk of death and hospitalization in patients with COPD.
Exercise testing can be useful in patients with a disproportional degree of dyspnea. It can be performed on a cycle or treadmill ergometer, or by a simple timed walking test (e.g., 6 minutes, or duration <6 minutes). Exercise testing is also of use in selecting patients for rehabilitation. Respiratory muscle function may also be tested if dyspnea or hypercapnia are disproportionately increased with respect to FEV1, as well as in patients with poor nutrition and those with corticosteroid myopathy.
In patients with frequent exacerbations, severe airflow limitation, and/or exacerbations requiring mechanical ventilation, sputum should be sent for culture. Echocardiogram evaluates suspected cardiac disease or pulmonary hypertension.
The World Health Organization (WHO) has specified a minimum set of interventions for the diagnosis of COPD in primary care. WHO: package of essential noncommunicable (PEN) disease interventions for primary health care Opens in new window
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