References
Key articles
Centres for Disease Control and Prevention. Clinician brief: hantavirus pulmonary syndrome (HPS). May 2026 [internet publication].Full text
Ulloa-Morrison R, Pavez N, Parra E, et al. Critical care management of hantavirus cardiopulmonary syndrome. A narrative review. J Crit Care. 2024 Dec;84:154867.Full text Abstract
Reference articles
1. Vial PA, Ferrés M, Vial C, et al. Hantavirus in humans: a review of clinical aspects and management. Lancet Infect Dis. 2023 Sep;23(9):e371-82. Abstract
2. Vapalahti O, Mustonen J, Lundkvist A, et al. Hantavirus infections in Europe. Lancet Infect Dis. 2003 Oct;3(10):653-61. Abstract
3. Kuhn JH, Schmaljohn CS. A brief history of bunyaviral family Hantaviridae. Diseases. 2023 Feb 28;11(1):38.Full text Abstract
4. Figueiredo LT, Souza WM, Ferrés M, et al. Hantaviruses and cardiopulmonary syndrome in South America. Virus Res. 2014 Jul 17;187:43-54. Abstract
5. Chapman LE, Ellis BA, Koster FT, et al. Discriminators between hantavirus-infected and -uninfected persons enrolled in a trial of intravenous ribavirin for presumptive hantavirus pulmonary syndrome. Clin Infect Dis. 2002 Feb 1;34(3):293-304.Full text Abstract
6. Centers for Disease Control and Prevention. 2026 multi-country hantavirus cluster linked to cruise ship. May 2026 [internet publication].Full text
7. Afzal S, Ali L, Batool A, et al. Hantavirus: an overview and advancements in therapeutic approaches for infection. Front Microbiol. 2023;14:1233433.Full text Abstract
10. Peters CJ, Khan AS. Hantavirus pulmonary syndrome: the new American hemorrhagic fever. Clin Infect Dis. 2002 May 1;34(9):1224-31.Full text Abstract
11. Hjelle B, Goade D, Torrez-Martinez N, et al. Hantavirus pulmonary syndrome, renal insufficiency and myositis associated with infection by Bayou hantavirus. Clin Infect Dis. 1996 Sep;23(3):495-500. Abstract
12. Khan AS, Gaviria M, Rollin PE, et al. Hantavirus pulmonary syndrome in Florida: association with the newly identified Black Creek Canal virus. Am J Med. 1996 Jan;100(1):46-8. Abstract
13. Centers for Disease Control and Prevention. Reported cases of hantavirus disease. Apr 2026 [internet publication].Full text
14. Kerins JL, Koske SE, Kazmierczak J, et al. Outbreak of Seoul virus among rats and rat owners - United States and Canada, 2017. Can Commun Dis Rep. 2018 Feb 1;44(2):71-4.Full text Abstract
15. Abbott KD, Ksiazek TG, Mills JN. Long-term hantavirus persistence in rodent populations in central Arizona. Emerg Infect Dis. 1999 Jan-Feb;5(1):102-12.Full text Abstract
16. Butler JC, Peters CJ. Hantaviruses and hantavirus pulmonary syndrome. Clin Infect Dis. 1994 Sep;19(3):387-94;quiz 395. Abstract
17. Núñez JJ, Fritz CL, Knust B, et al. Hantavirus infections among overnight visitors to Yosemite National Park, California, USA, 2012. Emerg Infect Dis. 2014 Mar;20(3):386-93.Full text Abstract
18. World Health Organization. Hantavirus pulmonary syndrome - Argentine Republic. Jan 2019 [internet publication].Full text
19. Centers for Disease Control and Prevention. Morbidity and Mortality Weekly Report. Notes from the field: contact tracing investigation after first case of andes virus in the United States — Delaware, February 2018. Oct 2018 [internet publication].Full text
20. Hjelle B, Glass GE. Outbreak of hantavirus infection in the Four Corners region of the United States in the wake of the 1997-1998 El Nino-southern oscillation. J Infect Dis. 2000 May;181(5):1569-73.Full text Abstract
21. Calisher CH, Mills JN, Root JJ, et al. Hantaviruses: etiologic agents of rare but potentially life-threatening zoonotic diseases. J Am Vet Med Assoc. 2003 Jan 15;222(2):163-6. Abstract
22. Howard MJ, Doyle TJ, Koster FT, et al. Hantavirus pulmonary syndrome in pregnancy. Clin Infect Dis. 1999 Dec;29(6):1538-44.Full text Abstract
23. Medina RA, Torres-Perez F, Galeno H, et al. Ecology, genetic diversity, and phylogeographic structure of andes virus in humans and rodents in Chile. J Virol. 2009 Mar;83(6):2446-59.Full text Abstract
24. Martinez VP, Bellomo C, San Juan J, et al. Person-to-person transmission of Andes virus. Emerg Infect Dis. 2005 Dec;11(12):1848-53.Full text Abstract
25. Martinez-Valdebenito C, Calvo M, Vial C, et al. Person-to-person household and nosocomial transmission of andes hantavirus, Southern Chile, 2011. Emerg Infect Dis. 2014 Oct;20(10):1629-36.Full text Abstract
26. Ferres M, Vial P, Marco C, et al. Prospective evaluation of household contacts of persons with hantavirus cardiopulmonary syndrome in Chile. J Infect Dis. 2007 Jun 1;195(11):1563-71.Full text Abstract
27. Godoy P, Marsac D, Stefas E, et al. Andes virus antigens are shed in urine of patients with acute hantavirus cardiopulmonary syndrome. J Virol. 2009 May;83(10):5046-55.Full text Abstract
28. UK Health Security Agency. Hantavirus: human-to-human infection transmission parameters. May 2026 [internet publication].Full text
29. Toledo J, Haby MM, Reveiz L, et al. Evidence for human-to-human transmission of hantavirus: a systematic review. J Infect Dis. 2022 Oct 17;226(8):1362-71.Full text Abstract
30. Castillo C, Villagra E, Sanhueza L, et al. Prevalence of antibodies to hantavirus among family and health care worker contacts of persons with hantavirus cardiopulmonary syndrome: lack of evidence for nosocomial transmission of Andes virus to health care workers in Chile. Am J Trop Med Hyg. 2004 Mar;70(3):302-4.Full text Abstract
31. Fritz CL, Young JC. Estimated incubation period for hantavirus pulmonary syndrome. Am J Trop Med Hyg. 2001 Nov;65(5):403. Abstract
32. St Jeor SC. Three-week incubation period for hantavirus infection. Pediatr Infect Dis J. 2004 Oct;23(10):974-5. Abstract
33. Borges AA, Campos GM, Moreli ML, et al. Hantavirus cardiopulmonary syndrome: immune response and pathogenesis. Microbes Infect. 2006 Jul;8(8):2324-30. Abstract
34. Bharadwaj M, Nofchissey R, Goade D, et al. Humoral immune responses in the hantavirus cardiopulmonary syndrome. J Infect Dis. 2000 Jul;182(1):43-8.Full text Abstract
35. Green W, Feddersen R, Yousef O, et al. Tissue distribution of hantavirus antigen in naturally infected humans and deer mice. J Infect Dis. 1998 Jun;177(6):1696-700. Abstract
36. Zavasky DM, Hjelle B, Peterson MC, et al. Acute infection with Sin Nombre hantavirus without pulmonary edema. Clin Infect Dis. 1999 Sep;29(3):664-6. Abstract
37. Maes P, Clement J, Gavrilovskaya I, et al. Hantaviruses: immunology, treatment, and prevention. Viral Immunol. 2004;17(4):481-97. Abstract
38. Mori M, Rothman AL, Kurane I, et al. High levels of cytokine-producing cells in the lung tissues of patients with fatal hantavirus pulmonary syndrome. J Infect Dis. 1999 Feb;179(2):295-302.Full text Abstract
39. Gavrilovskaya IN, Gorbunova EE, Mackow ER. Pathogenic hantaviruses direct the adherence of quiescent platelets to infected endothelial cells. J Virol. 2010 May;84(9):4832-9.Full text Abstract
40. Steinberg BE, Goldenberg NM, Lee WL. Do viral infections mimic bacterial sepsis? The role of microvascular permeability: a review of mechanisms and methods. Antiviral Res. 2012 Jan;93(1):2-15. Abstract
41. Geimonen E, LaMonica R, Springer K, et al. Hantavirus pulmonary syndrome-associated hantaviruses contain conserved and functional ITAM signaling elements. J Virol. 2003 Jan;77(2):1638-43.Full text Abstract
42. Borges AA, Figueiredo LT. Mechanisms of shock in hantavirus pulmonary syndrome. Curr Opin Infect Dis. 2008 Jun;21(3):293-7. Abstract
43. Saggioro FP, Rossi MA, Duarte MIS, et al. Hantavirus infection induces a typical myocarditis that may be responsible for myocardial depression and shock in hantavirus pulmonary syndrome. J Infect Dis. 2007 May 15;195(10):1541-9.Full text Abstract
44. Raftery MJ, Lalwani P, Krautkrӓmer E, et al. β2 integrin mediates hantavirus-induced release of neutrophil extracellular traps. J Exp Med. 2014 Jun 30;211(7):1485-97.Full text Abstract
45. Centers for Disease Control and Prevention. Hantavirus prevention. May 2024 [internet publication].Full text
46. Brocato RL, Hooper JW. Progress on the prevention and treatment of hantavirus disease. Viruses. 2019 Jul 4;11(7):610.Full text Abstract
47. Jonsson CB, Hooper J, Mertz G. Treatment of hantavirus pulmonary syndrome. Antiviral Res. 2008 Apr;78(1):162-9.Full text Abstract
48. Paulsen GC, Frenck R Jr, Tomashek KM, et al. Safety and immunogenicity of an Andes virus DNA vaccine by needle-free injection: a randomized, controlled phase 1 study. J Infect Dis. 2024 Jan 12;229(1):30-8.Full text Abstract
49. Centers for Disease Control and Prevention. Appendix A: type and duration of precautions recommended for selected infections and conditions. Feb 2025 [internet publication].Full text
50. World Health Organization. Standard precautions for the prevention and control of infections: aide-memoire. Jun 2022 [internet publication].Full text
51. UK Health Security Agency. Andes hantavirus: epidemiology, outbreaks and guidance. May 2021 [internet publication].Full text
52. Mertz GJ, Hjelle B, Crowley M, et al. Diagnosis and treatment of new world hantavirus infections. Curr Opin Infect Dis. 2006 Oct;19(5):437-42. Abstract
53. Ferrer JF, Jonsson CB, Esteban E, et al. High prevalence of hantavirus infection in Indian communities of the Paraguayan and Argentinean Gran Chaco. Am J Trop Med Hyg. 1998 Sep;59(3):438-44.Full text Abstract
54. Campos GM, Moro de Sousa RL, Badra SJ, et al. Serological survey of hantavirus in Jardinopolis County, Brazil. J Med Virol. 2003 Nov;71(3):417-22. Abstract
55. Muñoz-Zanzi C, Saavedra F, Otth C, et al. Serological evidence of hantavirus infection in apparently healthy people from rural and slum communities in southern Chile. Viruses. 2015 Apr 17;7(4):2006-13.Full text Abstract
56. Smith HM, Reporter R, Rood MP, et al. Prevalence study of antibody to ratborne pathogens and other agents among patients using a free clinic in downtown Los Angeles. J Infect Dis. 2002;186:1673-1676. Abstract
57. Yanagihara R. Hantavirus infection in the United States: epizootiology and epidemiology. Rev Infect Dis. 1990;12:449-457. Abstract
58. Chang B, Crowley M, Campen M, et al. Hantavirus cardiopulmonary syndrome. Semin Respir Crit Care Med. 2007 Apr;28(2):193-200. Abstract
59. Koster F, Foucar K, Hjelle B, et al. Rapid presumptive diagnosis of hantavirus cardiopulmonary syndrome by peripheral blood smear review. Am J Clin Pathol. 2001 Nov;116(5):665-72.Full text Abstract
60. Centres for Disease Control and Prevention. Clinician brief: hantavirus pulmonary syndrome (HPS). May 2026 [internet publication].Full text
61. World Health Organization. Hantavirus. May 2026 [internet publication].Full text
62. Centers for Disease Control and Prevention. Hantavirus pulmonary syndrome (HPS) 2015 case definition. Apr 2021 [internet publication].Full text
63. Vial C, Martinez-Valdebenito C, Rios S, et al. Molecular method for the detection of Andes hantavirus infection: validation for clinical diagnostics. Diagn Microbiol Infect Dis. 2016 Jan;84(1):36-9.Full text Abstract
64. World Health Organization. Laboratory testing of Andes virus (Orthohantavirus andesense) infection: interim guidance, 15 May 2026. May 2026 [internet publication].Full text
65. Centers for Disease Control and Prevention. 2026 hantavirus outbreak: testing for potential infection. May 2026 [internet publication].Full text
66. Centers for Disease Control and Prevention. About hantavirus. May 2024 [internet publication].Full text
67. Machado AM, Figueiredo GG, Dos Santos Junior GS, et al. Laboratory diagnosis of human hantavirus infection: novel insights and future potential. Future Virol. 2009;4:383-9.
68. Crowley MR, Katz RW, Kessler R, et al. Successful treatment of adults with severe Hantavirus pulmonary syndrome with extracorporeal membrane oxygenation. Crit Care Med. 1998 Feb;26(2):409-14. [Erratum in: Crit Care Med. 1998 Apr;26(4):806.] Abstract
69. Ulloa-Morrison R, Pavez N, Parra E, et al. Critical care management of hantavirus cardiopulmonary syndrome. A narrative review. J Crit Care. 2024 Dec;84:154867.Full text Abstract
70. Hallin GW, Simpson SQ, Crowell RE, et al. Cardiopulmonary manifestations of hantavirus pulmonary syndrome. Crit Care Med. 1996 Feb;24(2):252-8. Abstract
71. Nolte KB, Feddersen RM, Foucar K, et al. Hantavirus pulmonary syndrome in the United States: a pathological description of a disease caused by a new agent. Hum Pathol. 1995 Jan;26(1):110-20. Abstract
72. Boroja M, Barrie JR, Raymond GS. Radiographic findings in 20 patients with Hantavirus pulmonary syndrome correlated with clinical outcome. AJR Am J Roentgenol. 2002 Jan;178(1):159-63.Full text Abstract
73. de Oliveira RC, Guterres A, Teixeira BR, et al. A fatal hantavirus pulmonary syndrome misdiagnosed as dengue: an investigation into the first reported case in Rio de Janeiro State, Brazil. Am J Trop Med Hyg. 2017 Jul;97(1):125-9.Full text Abstract
74. Ketai LH, Kelsey CA, Jordon K, et al. Distinguishing hantavirus pulmonary syndrome from acute respiratory distress syndrome by chest radiography: are there different radiographic manifestations of increased alveolar permeability? J Thorac Imaging. 1998 Jul;13(3):172-7. Abstract
75. World Health Organization. Hantavirus outbreak toolbox. May 2026 [internet publication].Full text
76. World Health Organization. Management of contacts of Andes virus (ANDV) cases from the MV Hondius cruise ship. May 2026 [internet publication].Full text
77. Centers for Disease Control and Prevention. Interim guidance for public health assessment and management of people with potential exposure to Andes virus. May 2026 [internet publication].Full text
78. Wernly JA, Dietl CA, Tabe CE, et al. Extracorporeal membrane oxygenation support improves survival of patients with Hantavirus cardiopulmonary syndrome refractory to medical treatment. Eur J Cardiothorac Surg. 2011 Dec;40(6):1334-40.Full text Abstract
79. Moore SA, Dietl CA, Coleman DM. Extracorporeal life support during pregnancy. J Thorac Cardiovasc Surg. 2016 Apr;151(4):1154-60. Abstract
80. Safronetz D, Falzarano D, Scott DP, et al. Antiviral efficacy of favipiravir against two prominent etiological agents of hantavirus pulmonary syndrome. Antimicrob Agents Chemother. 2013;57:4673-4680.Full text Abstract
81. Munir N, Jahangeer M, Hussain S, et al. Hantavirus diseases pathophysiology, their diagnostic strategies and therapeutic approaches: A review. Clin Exp Pharmacol Physiol. 2021 Jan;48(1):20-34. Abstract
82. Mertz GJ, Miedzinski L, Goade D, et al. Placebo controlled, double blind trial of intravenous ribavirin for the treatment of hantavirus cardiopulmonary syndrome in North America. Clin Infect Dis. 2004 Nov 1;39(9):1307-13.Full text Abstract
83. Chapman LE, Mertz GJ, Peters CJ, et al. Intravenous ribavirin for hantavirus pulmonary syndrome: safety and tolerance during 1 year of open label experience. Ribavirin Study Group. Antivir Ther. 1999;4(4):211-9. Abstract
84. Vial PA, Valdivieso F, Calvo M et al. A non-randomized multicentre trial of human immune plasma for treatment of hantavirus cardiopulmonary syndrome caused by Andes virus. Antivir Ther. 2015;20:377-386. Abstract
85. Vial PA, Valdivieso F, Ferres M, et al. High-dose intravenous methylprednisolone for hantavirus cardiopulmonary syndrome in Chile: a double-blind, randomized controlled clinical trial. Clin Infect Dis. 2013 Oct;57(7):943-51.Full text Abstract
86. Centers for Disease Control and Prevention. Hantavirus outbreak toolkit. May 2026 [internet publication].Full text
87. World Health Organization. WHO Technical note for the disembarkation and onward management of passengers and crew in the context of an Andes virus-associated cluster MV Hondius cruise ship. May 2026 [internet publication].Full text
88. Pan American Health Organization. Hantavirus in the Americas: guidelines for prevention, diagnosis, treatment, and control. 1999 [internet publication].Full text
89. Jacob AT, Ziegler BM, Farha SM, et al. Sin Nombre virus and the emergence of other hantaviruses: a review of the biology, ecology, and disease of a zoonotic pathogen. Biology (Basel). 2023 Nov 9;12(11):1413.Full text Abstract
90. Centers for Disease Control and Prevention. Morbidity and mortality weekly report: hantavirus pulmonary syndrome -United States, 1995 and 1996. Apr 1996 [internet publication].Full text
91. Gracia F, Armien B, Simpson SQ, et al. Convalescent pulmonary dysfunction following hantavirus pulmonary syndrome in Panama and the United States. Lung. 2010 Oct;188(5):387-91.Full text Abstract
92. Pergam SA, Schmidt DW, Nofchissey RA, et al. Potential renal sequelae in survivors of hantavirus cardiopulmonary syndrome. Am J Trop Med Hyg. 2009;80:279-285. Abstract
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