Overview of skin cancer

Last reviewed: 4 Jan 2023
Last updated: 14 Oct 2022

This page compiles our content related to skin cancer. For further information on diagnosis and treatment, follow the links below to our full BMJ Best Practice topics on the relevant conditions and symptoms.

Introduction

Condition
Description

The most common malignancy of the skin in fair-skinned adults in the US, Australia, and Europe.[5] CRUK Cancer incidence statistics Opens in new window It typically presents as pearly papules and/or plaques; non-healing scabs; small crusts and non-healing wounds; plaques, nodules, and tumours with rolled borders; or papules with associated telangiectasias.[6][7][Figure caption and citation for the preceding image starts]: Nodular basal cell carcinoma on the cheek, on background of diffuse solar damage with marked solar elastosisFrom the collection of Dr Robert A. Schwartz [Citation ends].com.bmj.content.model.overview.Caption@1bf72077 Strong risk factors include UV radiation, sun exposure, x-ray exposure, arsenic exposure, xeroderma pigmentosum, nevoid basal cell carcinoma (Gorlin-Goltz) syndrome, and history of transplantation. Metastases and advanced lesions are uncommon.

Ranges from in situ tumours (Bowen's disease) to invasive tumours and metastatic disease. Patients commonly present with a new or enlarging lesion that they are concerned about, which may be tender or itchy, or a non-healing wound originally caused by some trauma. In situ tumours are typically thin, flesh-coloured to erythematous, scaly plaques, while invasive squamous cell carcinoma (SCC) may present as an exophytic tumour or ulcer.[Figure caption and citation for the preceding image starts]: Squamous cell carcinoma on the ear with surrounding actinic damageFrom the collection of Dr Jessica M. Sheehan and Dr Keyoumars Soltani [Citation ends].com.bmj.content.model.overview.Caption@1c3987a4 Tumours may be friable and bleed easily and are located mostly on sun-exposed areas of skin, such as the head and neck (84%) and extensor upper extremities (13%).[8] Cumulative ultraviolet exposure and immunosuppression are major risk factors.

A malignant tumour arising from pigment-producing melanocytes found in the skin, eye, and central nervous system. Several variants exist. Typically presents as a deeply pigmented skin lesion that is new or changing in size, shape, or colour.[9][10][Figure caption and citation for the preceding image starts]: Superficial spreading malignant melanomaFrom the collection of Dr Hobart W. Walling [Citation ends].com.bmj.content.model.overview.Caption@34c86ce2Unlike basal cell carcinoma and squamous cell carcinoma, melanoma is most common at body sites that have received intense, intermittent sun/UV exposure.[11] Lesions are more common on the trunk in men and on the legs and feet in women.[12] Tanning beds and sun lamps have been positively correlated with melanoma.[13] The likelihood of metastatic disease as a complication is high, and in young adults melanoma is a common cause of cancer-related death.[14]

A low-grade vasoformative neoplasm associated with human herpesvirus-8 (HHV-8, also knows as Kaposi's sarcoma-associated herpesvirus [KSHV]) infection.[15] Lesions frequently involve mucocutaneous sites, but may become more extensive to involve the lymph nodes and visceral organs. Skin lesions evolve from an early patch, to a plaque, and later to ulcerating tumour nodules.[Figure caption and citation for the preceding image starts]: Kaposi sarcoma cutaneous purple-brown plaque on the footFrom the collection of Dr Bruce J. Dezube [Citation ends].com.bmj.content.model.overview.Caption@7d1f0f94 There are four main subtypes: classic (sporadic); endemic (observed in sub-Saharan Africa); epidemic (AIDS-related); iatrogenic (transplant-related). Among people who are HIV positive, early initiation of antiretroviral therapy (ART) is likely to be the most effective measure for the prevention of Kaposi's sarcoma.[16]

Heterogeneous group of uncommon disorders characterised by clonal accumulation of T lymphocytes primarily or exclusively in the skin. Mycosis fungoides and its leukaemic variant, Sézary syndrome, are the most common subtypes.[17] Establishing a diagnosis is often difficult, as the disease can manifest in a number of different ways, including flat patches, raised plaques, large tumours, and/or marked erythroderma (intense and widespread reddening of the skin).[Figure caption and citation for the preceding image starts]: Cutaneous T-cell lymphoma: extensive patch diseaseFrom the collection of the Christie NHS Foundation Trust, Manchester, UK; used with permission [Citation ends].com.bmj.content.model.overview.Caption@7845064f Diagnosis is based on clinical findings, skin biopsy (specimens should be sent for histology, immunophenotyping, and molecular studies), and laboratory blood tests, and usually requires specialist expertise.[17][18]

Lesions are skin-coloured, yellowish, or erythematous, ill-defined, irregularly shaped, small, scaly macules or plaques localised in sun-exposed areas of the body (e.g., forehead, lower lip, dorsum of the hands, forearms, bald areas of the scalp, and ears).[Figure caption and citation for the preceding image starts]: Regular actinic keratosisFrom the collection of the Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine [Citation ends].com.bmj.content.model.overview.Caption@7d23d57c Typically, they occur in middle-aged or older men with light-coloured skin and a history of chronic sun exposure. It has the potential to progress into an invasive squamous cell carcinoma (SCC). The risk of progression to SCC has been calculated to be between 0.025% and 16% per year.[19][20] Although diagnosed clinically, a biopsy may help to rule out SCC.

Sunburn is an acute inflammatory reaction of the skin induced by overexposure to UV radiation. Skin findings include erythema and oedema, with or without vesiculation, followed by desquamation. Symptoms include pain and/or pruritus. Acute sunburn is a self-limiting condition and typically requires only supportive care. Primary prevention via sun avoidance, physical protection, and the appropriate use of sunscreen is key to managing the condition, as cellular damage caused by UV radiation is irreversible and may with time increase the risk of skin cancer.

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