A low-grade vasoformative neoplasm that is associated with human herpesvirus-8 (HHV-8, also known as Kaposi sarcoma-associated herpesvirus [KSHV]) infection.
There are 4 main subtypes of Kaposi sarcoma: epidemic AIDS-related; classic sporadic; iatrogenic and transplant-associated; and African endemic.
Patients may present with multifocal cutaneous lesions, mucosal lesions, or lymph node or visceral involvement.
Therapy is given for symptom palliation, to prevent disease progression, and for cosmetic reasons.
Kaposi sarcoma (KS) is a low-grade vasoformative neoplasm associated with human herpesvirus-8 (HHV-8, also known as Kaposi sarcoma-associated herpesvirus [KSHV]) infection. Lesions frequently involve mucocutaneous sites, but may become more extensive to involve the lymph nodes and visceral organs. Skin lesions evolve from an early patch, to a plaque, and later to ulcerating tumor nodules.
History and exam
- male gender
- HIV infection
- drug abuse
- immunosuppression therapy
- human herpesvirus-8 (HHV-8, also known as Kaposi sarcoma-associated herpesvirus [KSHV]) infection
- central African ethnicity (Uganda, Malawi, Zambia, Zimbabwe, Swaziland)
- Jewish ethnicity
- Mediterranean ethnicity
- age <5 years or >50 years
Attending Hematologist and Oncologist
Virginia Mason Clinical Professor of Medicine
Division of Hematology and Oncology
University of Washington
DA is the author of articles cited in this topic.
Dr David Aboulafia would like to gratefully acknowledge Dr Liron Pantanowitz and Dr Bruce J. Dezube, previous contributors to this topic.
Consultant Medical Oncologist/Senior Lecturer
Department of Medical Oncology
Imperial College/Imperial Healthcare NHS Trust
Charing Cross Hospital
JS declares that he has no competing interests.
Department of Dermatology
Erasme University Hospital
TS declares that he has no competing interests.
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