Resumen
Definición
Anamnesis y examen
Principales factores de diagnóstico
- single or multiple scaly macules or plaques
- scaly lesions with a hyperkeratotic surface
- well-defined, scaly, brown lesions
- lesions resembling seborrheic keratosis, melanocytic nevus, and early malignant melanoma
- hypertrophic conical-shaped protuberances growing from the surface of the skin
- scaly red roughness with induration, fissuring, and ulceration of the lower lip and the vermilion border
- lesion on sun-exposed area of body
- skin-colored, papillomatous, elevated wartlike papules
- plaques with very mild scale over very thin shiny skin
- violaceous well-defined papules with fine white lines on the surface
Otros factores de diagnóstico
- evidence of sun damage to skin
- pruritus or bleeding
Factores de riesgo
- chronic exposure to UVB radiation
- light-colored skin, freckling, and albinism
- age >40 years
- male sex
- immunocompromise
- xeroderma pigmentosum
Pruebas diagnósticas
Pruebas diagnósticas que deben considerarse
- dermoscopy
- skin biopsy
Algoritmo de tratamiento
confluent scalp lesions
head and face lesions, excluding periorbital, actinic cheilitis, and confluent scalp lesions
periorbital
actinic cheilitis
back of hands
below the knee
Colaboradores
Autores
Brian Berman, MD, PhD
Professor Emeritus of Dermatology and Cutaneous Surgery
University of Miami Miller School of Medicine
Miami
Skin & Cancer Associates, LLP
Co-Director
Center for Clinical and Cosmetic Research
Aventura
FL
Divulgaciones
BB is, or has been, a paid consultant/advisor for Almirall (manufacturer of tirbanibulin), Lemonex, Berg/BPGBio Pharma, Novartis, Aiviva, Ferndale, Sensus, Novan, Pierre Fabre (manufacturer of 5-FU), Biofrontera (manufacturer of ALA), SUN (manufacturer of ALA), LEO (manufacturer of ingenol mebutate - removed from market), Sirnaomics, Menlo, Sonoma, PHD Biosciences, Birch BioMed, Mediwound, Mino Labs, and Thirona. He has been a speaker for Almirall (manufacturer of tirbanibulin), LEO (manufacturer of ingenol mebutate), and Sensus. His institution has received investigator funding from Biofrontera (manufacturer of ALA), LEO (manufacturer of ingenol mebutate), Pulse, Sirnaomics, Menlo, Birch BioMed, and Mediwound. BB has stock options in Thirona and Mino Labs.
Sadegh Amini, MD
Dermatologist
Skin and Cancer Associates
Voluntary Assistant Professor
Department of Dermatology and Cutaneous Surgery
University of Miami
Miller School of Medicine
Miami
FL
Divulgaciones
SA has been compensated by Primus Pharmaceuticals, Inc. for being a member of the clinical advisory board.
Revisores por pares
David S. Cassarino, MD, PhD
Assistant Professor
Departments of Pathology and Dermatology
UCLA
Los Angeles
CA
Divulgaciones
DSC declares that he has no competing interests.
Christopher Shea, MD
Dermatopathology Fellowship Director
University of Chicago
Section of Dermatology
Chicago
IL
Divulgaciones
CS declares that he has no competing interests.
Agradecimiento de los revisores por pares
Los temas de BMJ Best Practice se actualizan de forma continua de acuerdo con los desarrollos en la evidencia y en las guías. Los revisores por pares listados aquí han revisado el contenido al menos una vez durante la historia del tema.
Divulgaciones
Las afiliaciones y divulgaciones de los revisores por pares se refieren al momento de la revisión.
Referencias
Artículos principales
Berman B, Bienstock L, Kuritzky L, et al. Primary Care Education Consortium; Texas Academy of Family Physicians. Actinic keratoses: sequelae and treatments. Recommendations from a consensus panel. J Fam Pract. 2006 May;55(5):suppl 1-8. Resumen
de Berker D, McGregor JM, Mohd Mustapa MF, et al. British Association of Dermatologists' guidelines for the care of patients with actinic keratosis 2017. Br J Dermatol. 2017 Jan;176(1):20-43. Resumen
Eisen DB, Asgari MM, Bennett DD, et al. Guidelines of care for the management of actinic keratosis. J Am Acad Dermatol. 2021 Oct;85(4):e209-33.Texto completo Resumen
European Dermatology Forum. Evidence and consensus based (S3) guidelines for the treatment of actinic keratosis. 2015 [internet publication].Texto completo
Eisen DB, Dellavalle RP, Frazer-Green L, et al. Focused update: guidelines of care for the management of actinic keratosis. J Am Acad Dermatol. 2022 Aug;87(2):373-4.e5.Texto completo Resumen
Artículos de referencia
Una lista completa de las fuentes a las que se hace referencia en este tema está disponible para los usuarios con acceso a todo BMJ Best Practice.
Diferenciales
- Squamous cell carcinoma (SCC) in situ (Bowen disease)
- Invasive SCC
- Keratoacanthoma
Más DiferencialesGuías de práctica clínica
- Focused update: guidelines of care for the management of actinic keratosis
- Guidelines of care for the management of actinic keratosis
Más Guías de práctica clínica
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