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Basal cell carcinoma

最后审阅: 14 Sep 2025
最后更新: 20 Feb 2025

小结

定义

病史和体格检查

关键诊断因素

  • papules with associated telangiectasias
  • plaques, nodules, and tumors with rolled borders
  • small crusts and nonhealing wounds
  • nonhealing scabs
  • pearly papules and/or plaques
完整详情

其他诊断因素

  • metastases associated with large or neglected BCC
  • local destruction with advanced lesion
完整详情

危险因素

  • Ultraviolet (UV) radiation
  • sun exposure
  • x-ray exposure
  • arsenic exposure
  • aberrant hedgehog signaling pathway
  • xeroderma pigmentosum
  • nevoid basal cell carcinoma (Gorlin-Goltz) syndrome
  • history of nonmelanona skin cancer
  • childhood cancer survivors
  • transplant recipient
完整详情

Investigações diagnósticas

Primeiras investigações a serem solicitadas

  • biopsy for dermatohistopathology
Detalhes completos

Novos exames

  • in vivo multiphoton microscopy

Algoritmo de tratamento

Inicial

nevoid basal cell carcinoma (Gorlin-Goltz) syndrome

AGUDA

low-risk subtype in noncosmetically challenging location

low-risk subtype in cosmetically challenging location

high-risk subtype

CONTÍNUA

positive margins on initial procedure

complicated BCC recurrences and/or site not accessible to surgical and topical therapies

advanced disease

Colaboradores

Autores

Robert A. Schwartz, MD, MPH, DSc (Hon), MAE, FAAD, FRCP (Edin)
Robert A. Schwartz

Professor & Head

Dermatology

Rutgers University New Jersey Medical School

Newark

NJ

Declarações

RAS declares that he has no competing interests. RAS is an author of a number of references cited in this topic.

Agradecimentos

Professor Robert A. Schwartz would like to gratefully acknowledge Dr James R. DeBloom and Dr Drazen Jukic, the previous contributors to this topic.

Declarações

JRD and DJ declare that they have no competing interests.

Revisores

Richard Bull, BMBCh

Consultant Dermatologist

Homerton University Hospital NHS Foundation Trust

London

UK

Declarações

RB declares that he has no competing interests.

David Cassarino, MD, PhD

Assistant Professor

Department of Pathology and Laboratory Medicine

University of California

Los Angeles

CA

Declarações

DC declares that he has no competing interests.

Créditos aos pareceristas

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Referências

Nossas equipes internas de editoria e de evidências trabalham em conjunto com colaboradores internacionais especializados e pares revisores para garantir que forneçamos acesso às informações o mais clinicamente relevantes possível.

Principais artigos

Nasr I, McGrath EJ, Harwood CA, et al; British Association of Dermatologists' Clinical Standards Unit. British Association of Dermatologists guidelines for the management of adults with basal cell carcinoma 2021. Br J Dermatol. 2021 Nov;185(5):899-920.Texto completo  Resumo

National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: basal cell skin cancer [internet publication].Texto completo

Kim JYS, Kozlow JH, Mittal B, et al; Work Group, Invited Reviewers. Guidelines of care for the management of basal cell carcinoma. J Am Acad Dermatol. 2018 Mar;78(3):540-59.Texto completo  Resumo

Thomson J, Hogan S, Leonardi-Bee J, et al. Interventions for basal cell carcinoma of the skin. Cochrane Database Syst Rev. 2020 Nov 17;(11):CD003412.Texto completo  Resumo

Artigos de referência

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