Epidemiology

CLL is the most common leukemia in the Western world.[5][6]​​​​​ It represents approximately 1% of all new cancer cases in the US.[7] In 2026, an estimated 22,760 new cases of CLL, and 4350 associated deaths, are expected in the US.​​[7]

CLL is more common in men than in women (6.5 vs. 3.5 new cases per 100,000 persons, respectively; 2019-2023, age-adjusted US data).[7]​ Median age at diagnosis in the US is 71 years; approximately 70% of diagnoses occur in people age ≥65 years.[7] Incidence in the US is greatest in non-Hispanic white people (8.2 new cases per 100,000 males and 4.4 new cases per 100,000 females, respectively; 2019-2023, age-adjusted US data).[7]

In the UK, there are an estimated 3800 new cases of CLL each year (based on 2019, and 2021-2022 data).[8]

Although the incidence and prevalence of CLL in Asia, Latin America, and Africa is much lower than in the US, the clinical presentation, male-to-female ratio, and age group are similar.[9]

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