Last reviewed: September 2018
Last updated: February  2018

Summary

Definition

History and exam

Key diagnostic factors

  • shortness of breath and fatigue
  • lymphadenopathy
  • splenomegaly
  • hepatomegaly

Other diagnostic factors

  • B symptoms
  • recurrent infections
  • petechiae

Risk factors

  • age over 60 years
  • male gender
  • white ethnicity
  • family history of CLL

Diagnostic investigations

1st investigations to order

  • WBC count with differential
  • blood film
  • hemoglobin
  • platelet count
  • flow cytometry
Full details

Investigations to consider

  • fluorescent in situ hybridization (FISH)
  • molecular genetic analysis
  • direct antiglobulin test (DAT)
  • immunoglobulin levels
  • bone marrow aspirate and trephine biopsy
  • CT scan
Full details

Treatment algorithm

Contributors

Authors VIEW ALL

Consultant Haematologist

Department of Haematology & Stem Cell Transplantation

Birmingham Heartlands Hospital

Birmingham

UK

Disclosures

VM declares that she received a consultancy fee from Janssen, and a grant from Takeda for the ASH Annual Meeting 2014.

Consultant Haematologist

Department of Haematology & Stem Cell Transplantation

Birmingham Heartlands Hospital

Birmingham

UK

Disclosures

SP declares that he has received consultancy and speaker fees from Janssen, Gilead, AbbVie, Bristol-Myers Squibb, and Takeda.

Dr Vidhya Murthy and Dr Shankaranarayana Paneesha would like to gratefully acknowledge Dr Robert Chen, a previous contributor to this monograph. RC declares that he has no competing interests.

Peer reviewers VIEW ALL

Consultant Haemato-oncologist

Section of Haemato-Oncology

The Institute of Cancer Research

Sutton

UK

Disclosures

DC declares that he has no competing interests.

Associate Professor

Department of Medicine

Case Western Reserve University

Case Comprehensive Cancer Center

Cleveland

OH

Disclosures

PFC has received honoraria from Celgene for participation in a speaker bureau, and from Kite Pharma for participation in an advisory board.

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