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Glomerulonephritis

Последний просмотренный: 13 Sep 2025
Last updated: 14 Feb 2025

Резюме

Определение

Анамнез и осмотр

Ключевые диагностические факторы

  • hematuria
  • edema
  • hypertension
Полная информация

Другие диагностические факторы

  • oliguria
  • anorexia
  • nausea
  • malaise
  • weight loss
  • fever
  • skin rash
  • arthralgia
  • hemoptysis
  • abdominal pain
  • sore throat
  • hypervolemia
Полная информация

Факторы риска

  • group A beta-hemolytic Streptococcus
  • respiratory infections
  • gastrointestinal infections
  • hepatitis B
  • hepatitis C
  • infective endocarditis
  • HIV
  • systemic lupus erythematosus (SLE)
  • systemic vasculitis
  • lung cancer
  • colorectal cancer
  • Hodgkin lymphoma
  • non-Hodgkin lymphoma
  • leukemia
  • thymoma
  • hemolytic uremic syndrome
  • drugs
Полная информация

Диагностические исследования

Исследования, которые показаны в первую очередь

  • urinalysis and microscopy of urine sediment
  • comprehensive metabolic profile
  • estimated glomerular filtration rate (eGFR)
  • complete blood count
  • lipid profile
  • 24-hour urine collection
  • ultrasound of kidneys
Полная информация

Исследования, проведение которых нужно рассмотреть

  • spot urine protein:creatinine ratio (PCR)
  • spot urine albumin:creatinine ratio (ACR)
  • erythrocyte sedimentation rate (ESR) or C-reactive protein (CRP)
  • complement levels
  • rheumatoid factor
  • antineutrophil cytoplasmic antibody
  • antiglomerular basement membrane (GBM) antibody
  • antistreptolysin O antibody
  • antihyaluronidase
  • anti-DNase
  • anti-double-stranded DNA
  • antinuclear antibody
  • cryoglobulins
  • hepatitis C virus and hepatitis B virus serology
  • HIV serology
  • serum or urine protein electrophoresis
  • serum free light chains
  • drug screen
  • kidney biopsy
  • antiphospholipase A2 receptor antibodies
  • computed tomographic scan of chest and abdomen
Полная информация

Алгоритм лечения

Острый

mild disease

moderate-severe disease

rapidly progressive

Составители

Авторы

Nabeel Aslam, MD, FASN

Associate Professor of Medicine

Consultant Nephrologist

Mayo Clinic

Jacksonville

FL

Раскрытие информации

NA declares that he has served on advisory boards for Travere Therapeutics and Chinook Therapeutics. He has received research grants from Idorsia, Novartis, and Baxter.

Выражение благодарностей

Dr Nabeel Aslam would like to gratefully acknowledge Dr Jeremy Levy, Dr Padmanabhan Premkumar, Dr Priyanka Sharma, and Dr Ajay Kumar, previous contributors to this topic.

Раскрытие информации

JL, PP, PS, and AK declare that they have no competing interests.

Рецензенты

Martin Schreiber, MD

Department Chairman

Nephrology and Hypertension

Cleveland Clinic Foundation

Cleveland

OH

Disclosures

MS declares that he has no competing interests.

Patrick Naish, MB, FRCP

Teaching Fellow

Keele University Medical School

Keele

UK

Disclosures

PN declares that he has no competing interests.

Richard Banks, MBBS, FRCP, MD

Consultant Nephrologist

Gloucestershire Royal Hospital

Gloucester

UK

Disclosures

RB declares that he has no competing interests.

Mark Thomas, BSc, MBBS, MD, FRCP

Consultant Nephrologist

University Hospitals Birmingham

Birmingham

UK

Раскрытие информации

MT declares that he has no competing interests.

Peer reviewer acknowledgements

BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.

Disclosures

Peer reviewer affiliations and disclosures pertain to the time of the review.

Список литературы

Our in-house evidence and editorial teams collaborate with international expert contributors and peer reviewers to ensure that we provide access to the most clinically relevant information possible.

Основные статьи

Kidney Disease: Improving Global Outcomes (KDIGO) Glomerular Diseases Work Group. KDIGO 2021 Clinical practice guideline for the management of glomerular diseases. Kidney Int. 2021 Oct;100(4s):S1-276.Полный текст  Аннотация

Sethi S, De Vriese AS, Fervenza FC. Acute glomerulonephritis. Lancet. 2022 Apr 23;399(10335):1646-63. Аннотация

Walters GD, Willis NS, Cooper TE, et al. Interventions for renal vasculitis in adults. Cochrane Database Syst Rev. 2020 Jan 13;(1):CD003232.Полный текст  Аннотация

Статьи, указанные как источники

A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.
  • Glomerulonephritis images
  • Отличия

    • Nephrolithiasis
    • Bladder cancer
    • Renal cancer
    Больше Отличия
  • Diretrizes

    • KDIGO clinical practice guideline for antineutrophilic cytoplasmic antibody (ANCA)-associated vasculitis
    • KDIGO clinical practice guideline for the management of lupus nephritis
    Больше Diretrizes
  • Folhetos informativos para os pacientes

    Glomerulonephritis

    Kidney infection

    Mais Folhetos informativos para os pacientes
  • Calculadoras

    Glomerular Filtration Rate Estimate by CKD-EPI Equation

    Mais Calculadoras
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