Systemic lupus erythematosus

Generalized disorder that can affect any system.

Symptoms and signs may accumulate over time.

The diagnosis is made using criteria recommended by the American College of Rheumatology.

Treatments for mild to moderate serositis or arthritis include hydroxychloroquine, nonsteroidal anti-inflammatory drugs, or corticosteroids. Treatments for more severe disease may include cyclophosphamide, mycophenolate, or tacrolimus plus corticosteroids.

Systemic lupus erythematosus (SLE) is a chronic multisystem disorder that most commonly affects women during their reproductive years. It is characterized by the presence of antinuclear antibodies. In addition to constitutional symptoms, it most frequently involves the skin and joints, although serositis, nephritis, hematologic cytopenias, and neurologic manifestations may occur during the course of the disease. Earlier diagnosis and better management have resulted in a lower prevalence of life-threatening disease.