Marburg virus infection

Last reviewed: 18 Apr 2022
Last updated: 01 Oct 2021

Summary

Definition

History and exam

Key diagnostic factors

  • exposure to Marburg virus in previous 21 days
  • fever
  • myalgia
  • malaise
More key diagnostic factors

Other diagnostic factors

  • fatigue
  • diarrhoea
  • nausea/vomiting
  • severe headache
  • abdominal pain
  • sore throat
  • prostration
  • maculopapular rash
  • conjunctivitis
  • hiccups
  • difficulty breathing
  • anorexia
  • bleeding
  • tachycardia
  • hypotension
  • neurological signs
  • petechiae
Other diagnostic factors

Risk factors

  • living or working in, or arrival from, endemic area in previous 21 days
  • contact with infected body fluids
  • occupational exposure
  • bioterrorism
More risk factors

Diagnostic investigations

1st investigations to order

  • reverse transcriptase polymerase chain reaction (RT-PCR)
  • malaria investigations
More 1st investigations to order

Investigations to consider

  • serum electrolyte levels
  • serum creatinine and urea
  • blood lactate
  • ABG
  • FBC
  • coagulation studies
  • urinalysis
  • LFTs
  • serum amylase level
  • blood cultures
  • antigen-capture enzyme-linked immunosorbent assay (ELISA)
  • IgG antibodies
More investigations to consider

Treatment algorithm

ACUTE

all patients

Contributors

Authors

Lisa Bebell, MD

Infectious Diseases Division

Massachusetts General Hospital

Boston

MA

Disclosures

LB is the author of a reference cited in this topic.

Peer reviewers

Mark Kortepeter, MD, MPH

Professor of Epidemiology

University of Nebraska Medical Center

Omaha

NE

Disclosures

MK declares that he has no competing interests.

Vanessa Raabe, MD, MSc

Adult and Pediatric Infectious Disease Fellow

Emory University

Atlanta

GA

Disclosures

VR declares that she has no competing interests.

  • Marburg virus infection images
  • Differentials

    • Malaria infection
    • Ebola virus infection
    • Crimean-Congo haemorrhagic fever (CCHF)
    More Differentials
  • Guidelines

    • CDC Health Information for International Travel (the Yellow Book): viral hemorrhagic fevers
    • Marburg virus disease: origins, reservoirs, transmission and guidelines
    More Guidelines
  • padlock-lockedLog in or subscribe to access all of BMJ Best Practice

Use of this content is subject to our disclaimer