Last reviewed: 18 Apr 2022
Last updated: 01 Oct 2021
Summary
Definition
History and exam
Key diagnostic factors
- exposure to Marburg virus in previous 21 days
- fever
- myalgia
- malaise
More key diagnostic factors
Other diagnostic factors
- fatigue
- diarrhoea
- nausea/vomiting
- severe headache
- abdominal pain
- sore throat
- prostration
- maculopapular rash
- conjunctivitis
- hiccups
- difficulty breathing
- anorexia
- bleeding
- tachycardia
- hypotension
- neurological signs
- petechiae
Other diagnostic factors
Risk factors
- living or working in, or arrival from, endemic area in previous 21 days
- contact with infected body fluids
- occupational exposure
- bioterrorism
More risk factors
Diagnostic investigations
1st investigations to order
- reverse transcriptase polymerase chain reaction (RT-PCR)
- malaria investigations
More 1st investigations to order
Investigations to consider
- serum electrolyte levels
- serum creatinine and urea
- blood lactate
- ABG
- FBC
- coagulation studies
- urinalysis
- LFTs
- serum amylase level
- blood cultures
- antigen-capture enzyme-linked immunosorbent assay (ELISA)
- IgG antibodies
More investigations to consider
Treatment algorithm
ACUTE
all patients
Contributors
Authors
Lisa Bebell, MD
Infectious Diseases Division
Massachusetts General Hospital
Boston
MA
Disclosures
LB is the author of a reference cited in this topic.
Peer reviewers
Mark Kortepeter, MD, MPH
Professor of Epidemiology
University of Nebraska Medical Center
Omaha
NE
Disclosures
MK declares that he has no competing interests.
Vanessa Raabe, MD, MSc
Adult and Pediatric Infectious Disease Fellow
Emory University
Atlanta
GA
Disclosures
VR declares that she has no competing interests.
Differentials
- Malaria infection
- Ebola virus infection
- Crimean-Congo haemorrhagic fever (CCHF)
More DifferentialsGuidelines
- CDC Health Information for International Travel (the Yellow Book): viral hemorrhagic fevers
- Marburg virus disease: origins, reservoirs, transmission and guidelines
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