Rash in children is common. The differential diagnoses are extensive, ranging from self-limiting conditions (e.g., roseola) to life-threatening illnesses such as meningococcal disease.
Rash may be the first indication of a potentially serious multiorgan disease or sepsis and should be carefully evaluated (see Urgent considerations).
Rash may be categorized as maculopapular, pustular, vesiculobullous, diffuse/erythematous, or petechial/purpuric in nature. In many etiologies these forms may coexist or evolve from one form to another.
Initial considerations in evaluating a rash in children include the morphology, duration, and distribution. Age, sex, family history, medications, known allergies, and exposures are also of primary importance.
Generally, rash in the absence of fever or systemic symptoms is not urgent.
Macule: a flat area of color change <1 cm in size (e.g., viral exanthem [such as measles and rubella], morbilliform drug eruption).
Patch: a large macule >1 cm in size (e.g., viral exanthem [such as measles and rubella], morbilliform drug eruption).
Papule: a raised area <1 cm in size (e.g., wart).
Nodule: a larger papule, >1 cm in size (e.g., nodular prurigo).
Plaque: a flat-topped raised area (a cross between a nodule and a patch; e.g., psoriasis).
Vesicle: a small fluid-filled lesion (blister) <0.5 cm in size (e.g., varicella, eczema herpeticum).
Bulla: a larger vesicle >0.5 cm (e.g., bullous impetigo).
Pustule: a pus-filled lesion (e.g., folliculitis).
Wheal: a transient raised papule or plaque caused by dermal edema (e.g., urticaria).
Scale: flakes of stratum corneum (e.g., eczema, psoriasis).
Crust: dried serum, blood, or purulent exudate on the skin surface (e.g., impetigo).
Erosion: loss of epidermis, heals without scarring (e.g., Stevens-Johnson syndrome, toxic epidermal necrolysis).
Ulcer: loss of epidermis and dermis, heals with scarring (e.g., venous ulcer, pyoderma gangrenosum).
Excoriation: loss of epidermis following trauma such as scratching (e.g., as can be seen in eczema).
Fissure: a split in the skin (e.g., angular cheilitis, palmoplantar keratoderma).
Lichenification: thickening of the skin with accentuation of skin markings (e.g., chronic eczema, lichen simplex chronicus).
Purpura: an area of color change (red or purple) due to bleeding into the skin; does not blanch on pressure (e.g., vasculitis, disseminated intravascular coagulation).
Petechia: a pin-point purpuric lesion (e.g., vasculitis, disseminated intravascular coagulation).
Ecchymosis: a larger area of purpura (e.g., vasculitis, disseminated intravascular coagulation).
- Roseola infantum (sixth disease)
- Erythema infectiosum (fifth disease)
- Epstein-Barr virus (EBV) infection
- Atopic dermatitis
- Seborrheic dermatitis
- Irritant contact dermatitis
- Pityriasis rosea
- Tinea corporis
- Tinea capitis
- Insect bites or stings
- Erythema toxicum neonatorum
- Child abuse
- Self-harm/dermatitis artefacta
- Cutaneous candidiasis
- Cutaneous herpes simplex
- Molluscum contagiosum
- Measles (rubeola)
- Cytomegalovirus (CMV) infection
- Dengue fever
- HIV seroconversion
- Rubella (German measles)
- Hand-foot-and-mouth disease
- Allergic contact dermatitis
- Rocky Mountain spotted fever
- Lyme disease
- Simple drug eruption
- Stevens-Johnson syndrome/toxic epidermal necrolysis
- Drug reaction with eosinophilia and systemic symptoms (DRESS)
- Erythema multiforme
- Meningococcal disease
- Scarlet fever
- Staphylococcal scalded skin syndrome
- Toxic shock syndrome
- Infective endocarditis
- Food allergy
- Immune thrombocytopenia
- Kawasaki disease
- Juvenile arthritis
- IgA vasculitis (formerly known as Henoch-Schonlein purpura)
- Systemic lupus erythematosus
- Rheumatic fever
- Miliaria crystallina
- Transient neonatal pustular melanosis
Patricia Treadwell, MD
Professor Emeritus of Pediatrics and Dermatology
Indiana University School of Medicine
Riley Hospital for Children
PT declares that her spouse owns stocks in Eli Lilly and Company.
Nanette Silverberg, MD
Clinical Professor of Dermatology
Columbia University College of Physicians and Surgeons
New York City
NS declares that she has no competing interests.
Hugo van Bever, MD, PhD
Professor in Pediatrics
Department of Pediatrics
National University Hospital
HVB declares that he has no competing interests.
Linda Nield, MD, FAAP
Associate Professor of Pediatrics
West Virginia University School of Medicine
LN is an author of a reference cited in this topic.
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