Last reviewed:October 2019
Last updated:July  2019

Summary

Differentials

Common

  • Herpes simplex
  • Herpes zoster (shingles)
  • Varicella zoster, acute (chickenpox)
  • Dermatophyte infections (inflammatory or bullous tinea pedis)
  • Scabies
  • Impetigo
  • Friction blister
  • Miliaria
  • Eczematous dermatitis (allergic contact, nummular, and dyshidrotic)
  • Thermal burn
  • Frostbite

Uncommon

  • Staphylococcal scalded skin syndrome
  • Epidermolysis bullosa
  • Coma bullae
  • Nutritional deficiencies (zinc, biotin, niacin, essential fatty acids)
  • Porphyria cutanea tarda
  • Pseudoporphyria cutanea tarda
  • Diabetic bullae (bullosis diabeticorum)
  • Incontinentia pigmenti
  • Bullous ichthyosiform erythroderma (epidermolytic hyperkeratosis)
  • Mastocytosis
  • Bullous arthropod bite reaction
  • Erythema multiforme
  • Stevens-Johnson syndrome
  • Toxic epidermal necrolysis
  • Amyloidosis
  • Hand-foot-mouth disease
  • Congenital syphilis
  • Linear IgA disease
  • Chronic bullous disease of childhood
  • Pemphigus vulgaris
  • Pemphigus foliaceus (fogo selvagem, pemphigus erythematosus)
  • Paraneoplastic pemphigus
  • Bullous pemphigoid
  • Pemphigoid gestationis
  • Mucous membrane pemphigoid (cicatricial pemphigoid)
  • Epidermolysis bullosa acquisita
  • Bullous lupus erythematosus
  • Dermatitis herpetiformis

Contributors

Associate Professor

Department of Dermatology

Uniformed Services University of the Health Sciences

Bethesda

MD

Disclosures

JHM declares that he has no competing interests.

Dr Jon H. Meyerle would like to gratefully acknowledge Dr Keira L. Barr, a previous contributor to this topic.

Peer reviewersVIEW ALL

Professor of Dermato-Epidemiology

Center of Evidence Based Dermatology

Nottingham University Hospitals

NHS Trust

Queen's Medical Centre

Nottingham

UK

Disclosures

HCW declares that he has no competing interests.

Head of Department

Department of Dermatology

St George Hospital

Conjoint Professor

University of New South Wales

Sydney

Australia

Disclosures

DFM declares that she has no competing interests.

Associate Professor and Clinical Director

Section of Dermatology

University of Chicago

Chicago

IL

Disclosures

VPR declares that she has no competing interests.

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