Last reviewed: September 2018
Last updated: July  2018

Summary

Differentials

Common

  • Allergy to food or drug
  • Insect bites or stings
  • Adverse drug reaction to, e.g., antibiotic, anticonvulsant, or allopurinol
  • Chemotherapy
  • Enterovirus and echovirus infection
  • Fifth disease (erythema infectiosum)
  • Roseola infantum (sixth disease)
  • Epstein Barr virus (EBV) infection (infectious mononucleosis)
  • Cytomegalovirus (CMV) infection

Uncommon

  • Iodinated contrast media nonimmediate adverse reaction
  • Erythema multiforme major (toxic epidermal necrolysis or Stevens-Johnson syndrome)
  • Drug reaction with eosinophilia and systemic symptoms (DRESS)
  • Erythema multiforme
  • Systemic hypersensitivity syndrome
  • HIV-seroconversion exanthema
  • Acute hepatitis B virus infection
  • Acute hepatitis C virus infection
  • Rubella (German measles)
  • Rubeola (measles)
  • Meningococcemia
  • Scarlet fever
  • Staphylococcal scalded skin syndrome
  • Toxic shock syndrome (Staphylococcus exotoxin)
  • Rocky Mountain spotted fever or Mediterranean spotted fever
  • Acute graft-versus-host disease (aGVHD)
  • Kawasaki disease (mucocutaneous lymph node syndrome)
  • Juvenile-onset or adult-onset Still disease
  • Syphilis (secondary)
  • Ebola virus infection
  • Zika virus infection
  • Chikungunya virus infection
  • Dengue fever

Contributors

Authors VIEW ALL

Professor & Director of Pediatric Dermatology

Department of Dermatology and Pediatrics

UTHealth McGovern Medical School Houston

Houston

TX

Disclosures

AAH declares that she has no competing interests

Clinical Research Fellow

Department of Dermatology

University of Texas Health Sciences Center in Houston

Houston

TX

Disclosures

MD declares that she has no competing interests.

Dr Adelaide A. Hebert and Dr Mary DarConte would like to gratefully acknowledge Dr Mark Naftanel and Dr Hobart W. Walling, previous contributors to this topic. MN and HWW declare that they have no competing interests.

Peer reviewers VIEW ALL

Clinical Assistant Professor

University of Iowa College of Medicine

Iowa City

IA

Disclosures

BS declares that he has no competing interests.

Dermatologist

Town Square Dermatology

Coralville

IA

Disclosures

KS declares that she has no competing interests.

Use of this content is subject to our disclaimer