Last reviewed: June 2020
Last updated: March  2020

Summary

Definition

History and exam

Key diagnostic factors

  • potential exposure to measles
  • unimmunized or vaccine failure
  • fever
  • cough
  • coryza
  • conjunctivitis
  • Koplik spots
  • maculopapular rash

Risk factors

  • exposure to measles virus
  • no prior immunization against measles
  • failure to respond to measles vaccine

Diagnostic investigations

1st investigations to order

  • measles-specific IgM and IgG serology (ELISA)
More 1st investigations to order

Investigations to consider

  • acute and convalescent sera for measles-specific IgG
  • measles RNA detection by PCR
  • antigen detection by fluorescent antibody or PCR techniques
  • isolation of virus in tissue culture system
More investigations to consider

Treatment algorithm

Contributors

Professor of Pediatrics

Boston University School of Medicine

Boston Medical Center

Boston

MA

Disclosures

EB has received research grant funding from Pfizer for RSV and pneumococcal vaccine studies. She has received royalties writing for UptoDate (evaluation of newly arrived immigrants) and AAP (parasitic disease treatment).

Peer reviewersVIEW ALL

Associate Professor of Pediatrics

West Virginia University School of Medicine

Morgantown

WV

Disclosures

LN is an author of a reference cited in this topic.

Assistant Professor of Medicine

Associate Residency Program Director

University of Chicago

Chicago

IL

Disclosures

AS declares that she has no competing interests.

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