If a patient is brought to the emergency department with signs and symptoms of hyperglycemia (polyuria, polydipsia, and abdominal pain), volume depletion, acetone breath, and changes in mental status (even without a history of diabetes), then plasma glucose and urine ketones should be checked. In the presence of high plasma glucose and/or positive urine ketones, full diagnostic laboratory evaluations for DKA and hyperosmolar hyperglycemic state should be performed.[1]

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