Complications
Occurs in approximately 1 in 3000 cases, most commonly in children.[1] Thrombocytopenia is probably immune-mediated. Serious hemorrhagic complications may occur.
Maternal infection in pregnancy, particularly early in gestation, may cause spontaneous abortion, fetal death, or a wide spectrum of anatomic and laboratory anomalies.
Women who acquire rubella during pregnancy should be managed in consultation with experts in fetal-maternal medicine and infectious diseases.
Rare neurologic complications include progressive sclerosing panencephalitis, myelitis, optic neuritis, peripheral neuritis, and Guillain-Barre syndrome.
Symptoms typically develop several days after the rash. The overall prognosis is good, but severe disease with permanent neurologic sequelae has been reported.[46][47]
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