Last reviewed: June 2018
Last updated: March  2018

Summary

Definition

History and exam

Key diagnostic factors

  • potential exposure to measles
  • unimmunised or vaccine failure
  • fever
  • cough
  • coryza
  • conjunctivitis
  • Koplik's spots
  • maculopapular rash

Risk factors

  • exposure to measles virus
  • no prior immunisation against measles
  • failure to respond to measles vaccine

Diagnostic investigations

1st investigations to order

  • measles-specific IgM and IgG serology (ELISA)
Full details

Investigations to consider

  • acute and convalescent sera for measles-specific IgG and IgM
  • measles RNA detection by PCR
  • antigen detection by fluorescent antibody or PCR techniques
  • isolation of virus in tissue culture system
Full details

Treatment algorithm

ACUTE

Contributors

Authors VIEW ALL

Professor of Pediatrics

Boston University School of Medicine

Boston Medical Center

Boston

MA

Disclosures

EB has received grant funding to her institution for participation in clinical trials for PaxVax oral cholera vaccine. She has received royalties for writing for UptoDate (evaluation of newly arrived immigrants), AAP (parasitic disease treatment), and Elsevier (Immigrant Medicine). EB has received honoraria for consultancy for HostTherabiomics (travellers' diarrhoea), for speaking for Spire Learning (diarrhea), and for other CME talks (diarrhoea, vaccines).

Peer reviewers VIEW ALL

Associate Professor of Pediatrics

West Virginia University School of Medicine

Morgantown

WV

Disclosures

LN is an author of a reference cited in this topic.

Assistant Professor of Medicine

Associate Residency Program Director

University of Chicago

Chicago

IL

Disclosures

AS declares that she has no competing interests.

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