Last reviewed: April 2018
Last updated: April  2018

Summary

Definition

History and exam

Key diagnostic factors

  • dysuria (in women)
  • lymphadenopathy
  • genital ulcer
  • oral ulcer
  • fever

Other diagnostic factors

  • tingling sensation
  • headache/aseptic meningitis

Risk factors

  • HIV infection (risk factor for clinical disease)
  • immunosuppressive medications (risk factor for clinical disease)
  • female sex (risk factor for seropositivity)
  • black race (risk factor for seropositivity)
  • increasing age (risk factor for seropositivity)
  • high-risk sexual behavior (risk factor for seropositivity)
  • lack of condom use (risk factor for seropositivity)

Diagnostic investigations

1st investigations to order

  • viral culture
  • HSV PCR
  • type-specific serologic IgG assay
Full details

Treatment algorithm

Contributors

Authors VIEW ALL

Attending Physician

Division of Hospital Medicine

MedStar Georgetown University Hospital

Washington

DC

Disclosures

BDL declares that he has no competing interests.

Dr Benjamin D. Lorenz would like to gratefully acknowledge Dr Christine Johnson and Dr Anna Wald, previous contributors to this topic. CJ reports funding from AiCuris; grants from Agenus, Gilead, Genocea, Sanofi, and Vical to conduct clinical research studies; and royalties from Up To Date. AW reports grants from Agenus, Gilead, Genocea, Sanofi, and Vical to conduct clinical research studies. AW receives royalties from Up To Date. AW is an NIH grant recipient (NIH AI30731 and AI071113) and a consultant for Aicuris, Eisai, and Amgen.

Peer reviewers VIEW ALL

Associate Professor

Department of Surgical, Oncological and Oral Sciences

School of Dentistry

University of Palermo

Palermo

Italy

Disclosures

GP declares that he has no competing interests.

Professor of Medicine

University of North Carolina at Chapel Hill

Chapel Hill

NC

Disclosures

PL declares that he has no competing interests.

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