Last reviewed: May 2019
Last updated: March  2019

Summary

Definition

History and exam

Key diagnostic factors

  • dysuria (in women)
  • lymphadenopathy
  • genital ulcer
  • oral ulcer
  • fever

Other diagnostic factors

  • tingling sensation
  • headache/aseptic meningitis

Risk factors

  • HIV infection (risk factor for clinical disease)
  • immunosuppressive medications (risk factor for clinical disease)
  • female sex (risk factor for seropositivity)
  • black race (risk factor for seropositivity)
  • increasing age (risk factor for seropositivity)
  • high-risk sexual behavior (risk factor for seropositivity)
  • lack of condom use (risk factor for seropositivity)

Diagnostic investigations

1st investigations to order

  • viral culture
  • HSV polymerase chain reaction (PCR)
  • Glycoprotein G-based type-specific serology (gG1 and gG2)
Full details

Treatment algorithm

Contributors

Authors VIEW ALL

Attending Physician

Division of Hospital Medicine

MedStar Georgetown University Hospital

Washington

DC

Disclosures

BDL declares that he has no competing interests.

Dr Benjamin D. Lorenz would like to gratefully acknowledge Dr Christine Johnson and Dr Anna Wald, previous contributors to this topic.

Peer reviewers VIEW ALL

Associate Professor

Department of Surgical, Oncological and Oral Sciences

School of Dentistry

University of Palermo

Palermo

Italy

Disclosures

GP declares that he has no competing interests.

Professor of Medicine

University of North Carolina at Chapel Hill

Chapel Hill

NC

Disclosures

PL declares that he has no competing interests.

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