Mycoplasma infection

Last reviewed: 25 Aug 2022
Last updated: 09 Jun 2020



History and exam

Key diagnostic factors

  • presence of risk factors
  • persistent cough
  • dry cough
  • prolonged symptoms
  • fever
  • pneumonia on physical examination
  • exposure to a person with respiratory tract infection
More key diagnostic factors

Other diagnostic factors

  • throat involvement
  • rash
  • headache
  • bullous myringitis
  • hepatitis
  • urethritis
  • cervicitis
  • pelvic pain
Other diagnostic factors

Risk factors

  • close community settings
  • recent exposure
  • cigarette smoking
  • immunosuppression
  • asplenia
  • age <30 years
More risk factors

Diagnostic investigations

1st investigations to order

  • WBC count
  • haemoglobin
  • LFTs
  • oxygen saturation
  • urea
  • chest x-ray
More 1st investigations to order

Investigations to consider

  • polymerase chain reaction
  • serology
  • nasopharyngeal viral cultures
  • culture/Gram stain
More investigations to consider

Treatment algorithm


with pneumonia

with STD



Ran Nir-Paz, MD
Ran Nir-Paz

Associate Professor in Medicine

Department of Clinical Microbiology and Infectious Diseases

Hadassah-Hebrew University Medical Center




RNP has received research grants from US-Israel Binational Science Foundation, Hebrew University, Rosetrees Trust, and SpeeDx Ltd. RNP is chair of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Mycoplasma and Chlamydia Infections (ESGMAC). RNP is a consultant for and has stocks in eDAS Healthcare. RNP is an author of several references cited in this topic.

Peer reviewers

Enno Jacobs, MD


Institute for Medical Microbiology and Hygiene




EJ declares that he has no competing interests.

Laura J. Christie, MD

Research Scientist

Pediatric Infectious Disease

California Department of Public Health

Viral and Rickettsial Disease Laboratory




LC declares that she has no competing interests.

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  • Guidelines

    • British Association for Sexual Health and HIV national guideline for the management of infection with Mycoplasma genitalium
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  • Calculators

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