小结
鉴别诊断
常见
- 原发性下丘脑性闭经
- 情绪/躯体应激、进食障碍或女性运动员三联征
- 体质性发育延迟
- 营养缺乏或慢性疾病状态
- Kallman 综合征（促性腺激素分泌不足性性腺功能减退）
- 高催乳素血症
- 多囊卵巢综合征 (PCOS)
- 非典型的先天性肾上腺增生
- 特纳综合征或混合性性生殖腺发育不全
- MRKH综合征（苗勒管发育不全）
- 流出道梗阻症状，包括处女膜闭锁或存在阴道横膈
不常见
- 颅咽管瘤
- 促性腺激素释放激素（GnRH）受体缺乏
- 脑炎后
- 产生雄激素的卵巢肿瘤
- 产生雄激素的肾上腺肿瘤
- 双侧睾丸发育不全（Swyer 综合征）
- 5-α-还原酶缺乏
- 17α-羟化酶缺乏症
- 雄激素不敏感综合征
撰稿人
作者
Meir Jonathon Solnik, MD
Associate Professor of Obstetrics and Gynecology
Temerty Faculty of Medicine
University of Toronto
Head of Gynecology and Minimally Invasive Surgery
Mount Sinai Hospital & Women’s College Hospital
Toronto
Canada
利益声明
MJS is a consultant for Medtronic, Olympus, Hologic, and Abbvie; and has stock in Field Trip Health Ltd and Felix Health, Canada.
鸣谢
Dr Meir Jonathon Solnik would like to gratefully acknowledge Dr Jessica Papillon-Smith, a previous contributor to this topic.
利益声明
JP-S declared that she had no competing interests.
同行评议者
Joseph S. Sanfilippo, MD, MBA
Professor
Department of Obstetrics, Gynecology, and Reproductive Sciences
Vice Chairman
Reproductive Sciences
Director
Division of Reproductive Endocrinology and Infertility
University of Pittsburgh
Pittsburgh
PA
利益声明
JSS declares that he has no competing interests.
Mary Ann Lumsden, BSc Hons, MBBS, MRCOG, MD, FRCOG
Head of Section
Reproductive and Maternal Medicine
University of Glasgow Royal Infirmary
Glasgow
Scotland
利益声明
MAL declares that she has no competing interests.
Robert Shaw, MD
Professor and Chair
Department of Neurology
Wake Forest University School of Medicine
Winston-Salem
NC
利益声明
RS declares that he has no competing interests.
指南
- 苗勒管发育不全：诊断、处理和治疗
- 原发性卵巢功能不全的激素治疗
更多 指南
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