Assessment of primary amenorrhoea

Последний просмотренный: 15 Aug 2025
Last updated: 02 Sep 2025

Резюме

Отличия

Распространенные

  • Primary hypothalamic amenorrhoea
  • Emotional/physical stress, eating disorder, or relative energy deficiency in sport (RED-S)
  • Constitutional delay
  • Malnutrition or chronic disease state
  • Kallman syndrome (hypogonadotrophic hypogonadism)
  • Hyperprolactinaemia
  • Polycystic ovary syndrome (PCOS)
  • Non-classic congenital adrenal hyperplasia
  • Turner syndrome or mixed gonadal dysgenesis
  • Mayer-Rokitansky-Kuster-Hauser syndrome (Mullerian agenesis)
  • Outflow tract obstruction, including imperforate hymen or transverse vaginal septum
Полная информация

Редкие

  • Craniopharyngioma
  • Gonadotrophin-releasing hormone (GnRH) receptor mutations
  • Post-encephalitis
  • Androgen-producing ovarian tumour
  • Androgen-producing adrenal tumour
  • XY gonadal dysgenesis (Swyer syndrome)
  • 5-alpha-reductase deficiency
  • 17-alpha-hydroxylase (CYP17) deficiency
  • Androgen insensitivity syndrome
Полная информация

Составители

Авторы

Meir Jonathon Solnik, MD
Meir Jonathon Solnik

Professor of Obstetrics and Gynecology, Medical Imaging (by cross-appointment)

Temerty Faculty of Medicine

University of Toronto

Head of Gynecology and Minimally Invasive Surgery

Mount Sinai Hospital & Women’s College Hospital

Toronto

Canada

Раскрытие информации

MJS serves as an advisory board member for Pfizer, Integra Health, and Abbvie; and serves as a medical advisor for Felix Health Inc.

Выражение благодарностей

Dr Meir Jonathon Solnik would like to gratefully acknowledge Dr Jessica Papillon-Smith, a previous contributor to this topic.

Раскрытие информации

JP-S declared that she had no competing interests.

Рецензенты

Anne K Smith, MD, MS, FACOG

Assistant Professor

Yale University

New Haven

CT

Раскрытие информации

AKS declares that she has no competing interests.

Rachana Shah, MD

Associate Professor of Pediatrics

Children’s Hospital of Philadelphia

Philadelphia

PA

Раскрытие информации

RS declares that she has no competing interests.

Mary Ann Lumsden, BSc Hons, MBBS, MRCOG, MD, FRCOG

Head of Section

Reproductive and Maternal Medicine

University of Glasgow Royal Infirmary

Glasgow

Scotland

Раскрытие информации

MAL declares that she has no competing interests.

Peer reviewer acknowledgements

BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.

Disclosures

Peer reviewer affiliations and disclosures pertain to the time of the review.

Список литературы

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Основные статьи

Practice Committee of the American Society for Reproductive Medicine. Current evaluation of amenorrhea: a committee opinion. Fertil Steril. 2024 Jul;122(1):52-61.Полный текст  Аннотация

American College of Obstetricians and Gynecologists' Committee on Practice Bulletins-Gynecology. ACOG Committee Opinion No. 605: primary ovarian insufficiency in adolescents and young women. Obstet Gynecol. 2014 Jul;124(1):193-7.Полный текст  Аннотация

Legro RS, Arslanian SA, Ehrmann DA, et al. Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2013 Dec;98(12):4565-92.Полный текст  Аннотация

American College of Obstetricians and Gynecologists' Committee on Adolescent Health Care-Gynecology. ACOG Committee Opinion No. 728: Müllerian agenesis: diagnosis, management, and treatment. Obstet Gynecol. 2018 Jan;131(1):e35-42.Полный текст  Аннотация

Статьи, указанные как источники

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