Evaluation of secondary amenorrhea

Last reviewed: 27 Apr 2022
Last updated: 23 Feb 2022

Summary

Differentials

Common

  • Eating disorders or female athlete triad
  • Emotional or physical stress
  • Postcontraception with depot medroxyprogesterone
  • Hyperprolactinemia
  • Polycystic ovary syndrome (PCOS)
  • Idiopathic premature ovarian failure
  • Postchemoradiation ovarian failure
  • Chromosomal abnormality (Fragile X carrier, Turner syndrome mosaic)
  • Nonclassic congenital adrenal hyperplasia
  • Hypothyroidism
Full details

Uncommon

  • Malnutrition or chronic disease state
  • Empty sella syndrome
  • Sheehan syndrome (postpartum pituitary necrosis)
  • Postencephalitis
  • Androgen-producing ovarian tumor
  • Autoimmune premature ovarian failure
  • Androgen-producing adrenal tumor
  • Cushing syndrome
  • Asherman syndrome
  • Drug-induced
Full details

Contributors

Authors

Meir Jonathon Solnik, MD
Meir Jonathon Solnik

Associate Professor of Obstetrics and Gynaecology

University of Toronto Faculty of Medicine

Head of Gynaecology and Minimally Invasive Surgery

Sinai Health System

Site Chief of Gynaecology

Women’s College Hospital

Toronto

Canada

Disclosures

MJS is a consultant for Medtronic, , Olympus, Hologic, and AbbVie. He holds stock in Field Trip Health Ltd, and Felix Health, Canada.

Peer reviewers

Joseph S. Sanfilippo, MD, MBA

Professor

Department of Obstetrics, Gynecology, and Reproductive Sciences

Vice Chairman

Reproductive Sciences

Director

Division of Reproductive Endocrinology and Infertility

University of Pittsburgh

Pittsburgh

PA

Disclosures

JSS declares that he has no competing interests.

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