Acute exacerbation of chronic obstructive pulmonary disease

Cote CG, Dordelly LJ, Celli BR. Impact of COPD exacerbations on patient-centered outcomes. Chest. 2007 Mar;131(3):696-704.Abstract external link opens in a new window

Woodhead M, Blasi F, Ewig S, et al. Guidelines for the management of adult lower respiratory tract infections - full version. Clini Microbiol Infect. 2011 Nov;17(Suppl 6):E1-59.Full text external link opens in a new windowAbstract external link opens in a new window

Celli BR, MacNee W, Agusti A, et al; ATS/ERS Task Force. Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. Eur Respir J. 2004 Jun;23(6):932-46.Full text external link opens in a new windowAbstract external link opens in a new window

Spruit MA, Singh SJ, Garvey C, et al. An official American Thoracic Society/European Respiratory Society statement: key concepts and advances in pulmonary rehabilitation. Am J Respir Crit Care Med. 2013 Oct 15;188(8):e13-64.Abstract external link opens in a new window

Tang CY, Blackstock FC, Clarence M, et al. Early rehabilitation exercise program for inpatients during an acute exacerbation of chronic obstructive pulmonary disease: a randomized controlled trial. J Cardiopulm Rehabil Prev. 2012 May-Jun;32(3):163-9.Abstract external link opens in a new window

1. Global Initiative for Chronic Obstructive Lung Disease (GOLD). Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. 2021 [internet publication].Full text external link opens in a new window

2. Bastin AJ, Starling L, Ahmed R, et al. High prevalence of undiagnosed and severe chronic obstructive pulmonary disease at first hospital admission with acute exacerbation. Chron Respir Dis. 2010 Mar;7(2):91-7.Abstract external link opens in a new window

3. Hanania NA, Marciniuk DD. A unified front against COPD: clinical practice guidelines from the American College of Physicians, the American College of Chest Physicians, the American Thoracic Society, and the European Respiratory Society. Chest. 2011 Sep;140(3):565-6.Full text external link opens in a new windowAbstract external link opens in a new window

4. Jemal A, Ward E, Hao Y. Trends in the leading causes of death in the United States, 1970-2002. JAMA. 2005 Sep 14;294(10):1255-9.Full text external link opens in a new windowAbstract external link opens in a new window

5. Mannino DM, Buist AS. Global burden of COPD: risk factors, prevalence, and future trends. Lancet. 2007 Sep 1;370(9589):765-73.Abstract external link opens in a new window

6. Mannino DM, Doherty DE, Sonia Buist A. Global Initiative on Obstructive Lung Disease (GOLD) classification of lung disease and mortality: findings from the Atherosclerosis Risk in Communities (ARIC) study. Respir Med. 2006 Jan;100(1):115-22.Abstract external link opens in a new window

7. Buist AS, McBurnie MA, Vollmer WM, et al. International variation in the prevalence of COPD (the BOLD Study): a population-based prevalence study. Lancet. 2007 Sep 1;370(9589):741-50.Abstract external link opens in a new window

8. Menezes AM, Perez-Padilla R, Jardim JR, et al. Chronic obstructive pulmonary disease in five Latin American cities (the PLATINO study): a prevalence study. Lancet. 2005 Nov 26;366(9500):1875-81.Abstract external link opens in a new window

9. de Torres JP, Casanova C, Hernandez C, et al. Gender and COPD in patients attending a pulmonary clinic. Chest. 2005 Oct;128(4):2012-6.Abstract external link opens in a new window

10. Seemungal TA, Donaldson GC, Bhowmik A, et al. Time course and recovery of exacerbations in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2000 May;161(5):1608-13.Abstract external link opens in a new window

11. Seemungal TA, Donaldson GC, Paul EA, et al. Effect of exacerbation on quality of life in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1998 May;157(5 Pt 1):1418-22.Abstract external link opens in a new window

12. Rodriguez-Roisin R. COPD exacerbations.5: management. Thorax. 2006 Jun;61(6):535-44.Abstract external link opens in a new window

13. O'Donnell DE, Parker CM. COPD exacerbations. 3: Pathophysiology. Thorax. 2006 Apr;61(4):354-61.Abstract external link opens in a new window

14. Barberà JA, Roca J, Ferrer A, et al. Mechanisms of worsening gas exchange during acute exacerbations of chronic obstructive pulmonary disease. Eur Respir J. 1997 Jun;10(6):1285-91.Full text external link opens in a new windowAbstract external link opens in a new window

15. Cote CG, Dordelly LJ, Celli BR. Impact of COPD exacerbations on patient-centered outcomes. Chest. 2007 Mar;131(3):696-704.Abstract external link opens in a new window

16. Spencer S, Jones PW; GLOBE Study Group. Time course of recovery of health status following an infective exacerbation of chronic bronchitis. Thorax. 2003 Jul;58(7):589-93.Full text external link opens in a new windowAbstract external link opens in a new window

17. Xu W, Collet JP, Shapiro S, et al. Negative impacts of unreported COPD exacerbations on health-related quality of life at 1 year. Eur Respir J. 2010 May;35(5):1022-30.Abstract external link opens in a new window

18. Terada K, Muro S, Sato S, et al. Impact of gastro-oesophageal reflux disease symptoms on COPD exacerbation. Thorax. 2008 Nov;63(11):951-5.Abstract external link opens in a new window

19. Terada K, Muro S, Ohara T, et al. Abnormal swallowing reflex and COPD exacerbations. Chest. 2010 Feb;137(2):326-32.Abstract external link opens in a new window

20. Ingebrigtsen TS, Marott JL, Vestbo J, et al. Gastro-esophageal reflux disease and exacerbations in chronic obstructive pulmonary disease. Respirology. 2015 Jan;20(1):101-7.Full text external link opens in a new windowAbstract external link opens in a new window

21. Hurst JR, Vestbo J, Anzueto A, et al. Susceptibility to exacerbation in chronic obstructive pulmonary disease. N Engl J Med. 2010 Sep 16;363(12):1128-38.Full text external link opens in a new windowAbstract external link opens in a new window

22. Martinez CH, Okajima Y, Murray S, et al. Impact of self-reported gastroesophageal reflux disease in subjects from COPDGene cohort. Respir Res. 2014 Jun 3;15(1):62.Full text external link opens in a new windowAbstract external link opens in a new window

23. Rabe KF, Fabbri LM, Vogelmeier C, et al. Seasonal distribution of COPD exacerbations in the Prevention of Exacerbations with Tiotropium in COPD trial. Chest. 2013 Mar;143(3):711-9.Abstract external link opens in a new window

24. Sutherland ER, Cherniack RM. Management of chronic obstructive pulmonary disease. N Engl J Med. 2004 Jun 24;350(26):2689-97.Abstract external link opens in a new window

25. Ai-Ping C, Lee KH, Lim TK. In-hospital and 5-year mortality of patients treated in the ICU for acute exacerbation of COPD: a retrospective study. Chest. 2005 Aug;128(2):518-24.Abstract external link opens in a new window

26. Donaldson GC, Wedzicha JA. COPD exacerbations .1: Epidemiology. Thorax. 2002 Oct;57(10):847-52.Abstract external link opens in a new window

27. Seneff MG, Wagner DP, Wagner RP, et al. Hospital and 1-year survival of patients admitted to intensive care units with acute exacerbation of chronic obstructive pulmonary disease. JAMA. 1995 Dec 20;274(23):1852-7.Abstract external link opens in a new window

28. Soler N, Agusti C, Angrill J, et al. Bronchoscopic validation of the significance of sputum purulence in severe exacerbations of chronic obstructive pulmonary disease. Thorax. 2005 Nov;60(11):925-31.Abstract external link opens in a new window

29. Zvezdin B, Milutinov S, Kojicic M, et al. A postmortem analysis of major causes of early death in patients hospitalized with COPD exacerbation. Chest. 2009 Aug;136(2):376-80.Abstract external link opens in a new window

30. Donaldson GC, Hurst JR, Smith CJ, et al. Increased risk of myocardial infarction and stroke following exacerbation of COPD. Chest. 2010 May;137(5):1091-7.Abstract external link opens in a new window

31. Lundback B, Lindberg A, Lindstrom M, et al. Not 15 but 50% of smokers develop COPD?--Report from the Obstructive Lung Disease in Northern Sweden Studies. Respir Med. 2003 Feb;97(2):115-22.Abstract external link opens in a new window

32. Sapey E, Stockley RA. COPD exacerbations.2: aetiology. Thorax. 2006 Mar;61(3):250-8.Full text external link opens in a new windowAbstract external link opens in a new window

33. Hogg JC, Chu F, Utokaparch S, et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med. 2004 Jun 24;350(26):2645-53.Full text external link opens in a new windowAbstract external link opens in a new window

34. nzueto A. Primary care management of chronic obstructive pulmonary disease to reduce exacerbations and their consequences. Am J Med Sci. 2010 Oct;340(4):309-18.Abstract external link opens in a new window

35. Ritchie AI, Wedzicha JA. Definition, causes, pathogenesis, and consequences of chronic obstructive pulmonary disease exacerbations. Clin Chest Med. 2020 Sep;41(3):421-38.Full text external link opens in a new windowAbstract external link opens in a new window

36. Greenberg SB, Allen M, Wilson J, et al. Respiratory viral infections in adults with and without chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2000 Jul;162(1):167-73.Full text external link opens in a new windowAbstract external link opens in a new window

37. Woodhead M, Blasi F, Ewig S, et al. Guidelines for the management of adult lower respiratory tract infections - full version. Clini Microbiol Infect. 2011 Nov;17(Suppl 6):E1-59.Full text external link opens in a new windowAbstract external link opens in a new window

38. Lieberman D, Lieberman D, Ben-Yaakov M, et al. Infectious etiologies in acute exacerbation of COPD. Diagn Microbiol Infect Dis. 2001 Jul;40(3):95-102.Abstract external link opens in a new window

39. Beckham JD, Cadena A, Lin J, et al. Respiratory viral infections in patients with chronic obstructive pulmonary disease. J Infect. 2005 May;50(4):322-30.Full text external link opens in a new windowAbstract external link opens in a new window

40. Martinello RA, Esper F, Weibel C, et al. Human metapneumovirus and exacerbations of chronic obstructive pulmonary disease. J Infect. 2006 Oct;53(4):248-54.Abstract external link opens in a new window

41. Jafarinejad H, Moghoofei M, Mostafaei S, et al. Worldwide prevalence of viral infection in AECOPD patients: A meta-analysis. Microb Pathog. 2017 Dec;113:190-96.Full text external link opens in a new windowAbstract external link opens in a new window

42. Dennis RJ, Maldonado D, Norman S, et al. Woodsmoke exposure and risk for obstructive airways disease among women. Chest. 1996 Jan;109(1):115-9.Abstract external link opens in a new window

43. Sunyer J, Saez M, Murillo C, et al. Air pollution and emergency room admissions for chronic obstructive pulmonary disease: a 5-year study. Am J Epidemiol. 1993 Apr 1;137(7):701-5.Abstract external link opens in a new window

44. Eisner MD, Anthonisen N, Coultas D, et al. An official American Thoracic Society public policy statement: Novel risk factors and the global burden of chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2010 Sep 1;182(5):693-718.Full text external link opens in a new windowAbstract external link opens in a new window

45. Paulin LM, Diette GB, Blanc PD, et al. Occupational exposures are associated with worse morbidity in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2015 Mar 1;191(5):557-65.Full text external link opens in a new windowAbstract external link opens in a new window

46. Jones JG, Minty BD, Lawler P, et al. Increased alveolar epithelial permeability in cigarette smokers. Lancet. 1993 Apr 1;137(7):701-5.Abstract external link opens in a new window

47. Sethi S, Murphy TF. Bacterial infection in chronic obstructive pulmonary disease in 2000: a state-of-the-art review. Clin Microbiol Rev. 2001 Apr;14(2):336-63.Full text external link opens in a new windowAbstract external link opens in a new window

48. Barnes PJ. Chronic obstructive pulmonary disease. N Engl J Med. 2000 Jul 27;343(4):269-80.Abstract external link opens in a new window

49. Stockley RA. Progression of chronic obstructive pulmonary disease: impact of inflammation, comorbidities and therapeutic intervention. Curr Med Res Opin. 2009 May;25(5):1235-45.Abstract external link opens in a new window

50. Sethi S, Murphy TF. Infection in the pathogenesis and course of chronic obstructive pulmonary disease. N Engl J Med. 2008 Nov 27;359(22):2355-65.Abstract external link opens in a new window

51. Barnes PJ. Mechanisms in COPD: differences from asthma. Chest. 2000 Feb;117(2 Suppl):10S-4S.Abstract external link opens in a new window

52. Hogg JC. Pathophysiology of airflow limitation in chronic obstructive pulmonary disease. Lancet. 2004 Aug 21-27;364(9435):709-21.Abstract external link opens in a new window

53. Lougheed DM, Webb KA, O'Donnell DE. Breathlessness during induced lung hyperinflation in asthma: the role of the inspiratory threshold load. Am J Respir Crit Care Med. 1995 Sep;152(3):911-20.Abstract external link opens in a new window

54. Pauwels RA, Buist AS, Calverley PM, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary. Am J Respir Crit Care Med. 2001 Apr;163(5):1256-76.Abstract external link opens in a new window

55. Tashkin DP, Celli B, Decramer M, et al. Bronchodilator responsiveness in patients with COPD. Eur Respir J. 2008 Apr;31(4):742-50.Full text external link opens in a new windowAbstract external link opens in a new window

56. Belman MJ, Botnick WC, Shin JW. Inhaled bronchodilators reduce dynamic hyperinflation during exercise in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1996 Mar;153(3):967-75.Abstract external link opens in a new window

57. Celli B, ZuWallack R, Wang S, et al. Improvement in resting inspiratory capacity and hyperinflation with tiotropium in COPD patients with increased static lung volumes. Chest. 2003 Nov;124(5):1743-8.Abstract external link opens in a new window

58. Papi A, Bellettato CM, Braccioni F, et al. Infections and airway inflammation in chronic obstructive pulmonary disease severe exacerbations. Am J Respir Crit Care Med. 2006 May 15;173(10):1114-21.Abstract external link opens in a new window

59. Wedzicha JA, Seemungal TA. COPD exacerbations: defining their cause and prevention. Lancet. 2007 Sep 1;370(9589):786-96.Abstract external link opens in a new window

60. Hurst JR, Wedzicha JA. The biology of a chronic obstructive pulmonary disease exacerbation. Clin Chest Med. 2007 Sep;28(3):525-36.Abstract external link opens in a new window

61. Giacomini M, DeJean D, Simeonov D, et al. Experiences of living and dying with COPD: a systematic review and synthesis of the qualitative empirical literature. Ont Health Technol Assess Ser. 2012 Mar;12(13):1-47.Full text external link opens in a new windowAbstract external link opens in a new window

62. Burge S, Wedzicha JA. COPD exacerbations: definitions and classifications. Eur Respir J Suppl. 2003 Jun;41:46s-53s.Abstract external link opens in a new window

63. Donaldson GC, Seemungal TA, Bhowmik A, et al. Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease. Thorax. 2002 Oct;57(10):847-52.Abstract external link opens in a new window

64. Niewoehner DE, Lokhnygina Y, Rice K, et al. Risk indexes for exacerbations and hospitalizations due to COPD. Chest. 2007 Jan;131(1):20-8.Abstract external link opens in a new window

65. Foreman MG, DeMeo DL, Hersh CP, et al. Clinical determinants of exacerbations in severe, early-onset COPD. Eur Respir J. 2007 Dec;30(6):1124-30.Abstract external link opens in a new window

66. Seemungal TA, Harper-Owen R, Bhowmik A, et al. Detection of rhinovirus in induced sputum at exacerbation of chronic obstructive pulmonary disease. Eur Respir J. 2000 Oct;16(4):677-83.Full text external link opens in a new windowAbstract external link opens in a new window

67. Falsey AR, Formica MA, Hennessey PA, et al. Detection of respiratory syncytial virus in adults with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2006 Mar 15;173(6):639-43.Abstract external link opens in a new window

68. Hurst JR, Donaldson GC, Wilkinson TM, et al. Epidemiological relationships between the common cold and exacerbation frequency in COPD. Eur Respir J. 2005 Nov;26(5):846-52.Full text external link opens in a new windowAbstract external link opens in a new window

69. Hewitt R, Farne H, Ritchie A, et al. The role of viral infections in exacerbations of chronic obstructive pulmonary disease and asthma. Ther Adv Respir Dis. 2016 Apr;10(2):158-74.Full text external link opens in a new windowAbstract external link opens in a new window

70. Hogg JC. Role of latent viral infections in chronic obstructive pulmonary disease and asthma. Am J Respir Crit Care Med. 2001 Nov 15;164(10 Pt 2):S71-5.Abstract external link opens in a new window

71. White AJ, Gompertz S, Stockley RA. Chronic obstructive pulmonary disease. 6: The aetiology of exacerbations of chronic obstructive pulmonary disease. Thorax. 2003 Jan;58(1):73-80.Full text external link opens in a new windowAbstract external link opens in a new window

72. Wilkinson TM, Hurst JR, Perera WR, et al. Effect of interactions between lower airway bacterial and rhinoviral infection in exacerbations of COPD. Chest. 2006 Feb;129(2):317-24.Abstract external link opens in a new window

73. Sethi S, Sethi R, Eschberger K, et al. Airway bacterial concentrations and exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2007 Aug 15;176(4):356-61.Abstract external link opens in a new window

74. Caramori G, Adcock IM, Papi A. Clinical definition of COPD exacerbations and classification of their severity. South Med J. 2009 Mar;102(3):277-82.Abstract external link opens in a new window

75. Sethi S, Evans N, Grant BJ, et al. New strains of bacteria and exacerbations of chronic obstructive pulmonary disease. N Engl J Med. 2002 Aug 15;347(7):465-71.Abstract external link opens in a new window

76. Anthonisen NR, Manfreda J, Warren CP, et al. Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease. Ann Intern Med. 1987 Feb;106(2):196-204.Abstract external link opens in a new window

77. Puhan MA, Vollenweider D, Latshang T, et al. Exacerbations of chronic obstructive pulmonary disease: when are antibiotics indicated? A systematic review. Respir Res. 2007 Apr 4;8(1):30.Full text external link opens in a new windowAbstract external link opens in a new window

78. Anthonisen NR, Connett JE, Kiley JP, et al. Effects of smoking intervention and the use of an inhaled anticholinergic bronchodilator on the rate of decline of FEV1. The Lung Health Study. JAMA. 1994 Nov 16;272(19):1497-505.Abstract external link opens in a new window

79. Thabane M; COPD Working Group. Smoking cessation for patients with chronic obstructive pulmonary disease (COPD): an evidence-based analysis. Ont Health Technol Assess Ser. 2012;12(4):1-50.Full text external link opens in a new windowAbstract external link opens in a new window

80. Au DH, Bryson CL, Chien JW, et al. The effects of smoking cessation on the risk of chronic obstructive pulmonary disease exacerbations. J Gen Intern Med. 2009 Apr;24(4):457-63.Full text external link opens in a new windowAbstract external link opens in a new window

81. Criner GJ, Bourbeau J, Diekemper RL, et al. Prevention of acute exacerbations of COPD: American College of Chest Physicians and Canadian Thoracic Society Guideline. Chest. 2015 Apr;147(4):894-942.Full text external link opens in a new windowAbstract external link opens in a new window

82. Diederen BM, van der Valk PD, Kluytmans JA, et al. The role of atypical respiratory pathogens in exacerbations of chronic obstructive pulmonary disease. Eur Respir J. 2007 Aug;30(2):240-4.Abstract external link opens in a new window

83. Blasi F, Damato S, Cosentini R, et al. Chlamydia pneumoniae and chronic bronchitis: association with severity and bacterial clearance following treatment. Thorax. 2002 Aug;57(8):672-6.Abstract external link opens in a new window

84. Seemungal TA, Wedzicha JA, MacCallum PK, et al. Chlamydia pneumoniae and COPD exacerbation. Thorax. 2002 Dec;57(12):1087-8.Abstract external link opens in a new window

85. Anderson HR, Spix C, Medina S, et al. Air pollution and daily admissions for chronic obstructive pulmonary disease in 6 European cities: results from the APHEA project. Eur Respir J. 1997 May;10(5):1064-71.Abstract external link opens in a new window

86. Yang CY, Chen CC, Chen CY, et al. Air pollution and hospital admissions for asthma in a subtropical city: Taipei, Taiwan. J Toxicol Environ Health A. 2007 Jan 15;70(2):111-7.Abstract external link opens in a new window

87. Pope CA, 3rd, Kanner RE. Acute effects of PM10 pollution on pulmonary function of smokers with mild to moderate chronic obstructive pulmonary disease. Am Rev Respir Dis. 1993 Jun;147(6 Pt 1):1336-40.Abstract external link opens in a new window

88. Faustini A, Stafoggia M, Colais P, et al. Air pollution and multiple acute respiratory outcomes. Eur Respir J. 2013 Aug;42(2):304-13.Full text external link opens in a new windowAbstract external link opens in a new window

89. Donaldson GC, Seemungal T, Jeffries DJ, et al. Effect of temperature on lung function and symptoms in chronic obstructive pulmonary disease. Eur Respir J. 1999 Apr;13(4):844-9.Abstract external link opens in a new window

90. Chen CZ, Ou CY, Yu CH, et al. Comparison of global initiative for chronic obstructive pulmonary disease 2013 classification and body mass index, airflow obstruction, dyspnea, and exacerbations index in predicting mortality and exacerbations in elderly adults with chronic obstructive pulmonary disease. J Am Geriatr Soc. 2015 Feb;63(2):244-50.Abstract external link opens in a new window

91. McCrory DC, Brown C, Gelfand SE, et al. Management of acute exacerbations of COPD: a summary and appraisal of published evidence. Chest. 2001 Apr;119(4):1190-209.Abstract external link opens in a new window

92. Nichol KL, Baken L, Nelson A. Relation between influenza vaccination and outpatient visits, hospitalization, and mortality in elderly persons with chronic lung disease. Ann Intern Med. 1999 Mar 2;130(5):397-403.Abstract external link opens in a new window

93. Wongsurakiat P, Maranetra KN, Wasi C, et al. Acute respiratory illness in patients with COPD and the effectiveness of influenza vaccination: a randomized controlled study. Chest. 2004 Jun;125(6):2011-20.Abstract external link opens in a new window

94. Sehatzadeh S. Influenza and pneumococcal vaccinations for patients with chronic obstructive pulmonary disease (COPD): an evidence-based review. Ont Health Technol Assess Ser. 2012 Mar;12(3):1-64.Full text external link opens in a new windowAbstract external link opens in a new window

95. OHTAC COPD Collaborative. Chronic obstructive pulmonary disease (COPD) evidentiary framework. Ont Health Technol Assess Ser. 2012 Mar;12(2):1-97.Full text external link opens in a new windowAbstract external link opens in a new window

96. Alfageme I, Vazquez R, Reyes N, et al. Clinical efficacy of anti-pneumococcal vaccination in patients with COPD. Thorax. 2006 Mar;61(3):189-95.Abstract external link opens in a new window

97. Walters JA, Tang JN, Poole P, Wood-Baker R. Pneumococcal vaccines for preventing pneumonia in chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2017 Jan 24;(1):CD001390.Full text external link opens in a new windowAbstract external link opens in a new window

98. Matanock A, Lee G, Gierke R, et al. Use of 13-valent pneumococcal conjugate vaccine and 23-valent pneumococcal polysaccharide vaccine among adults aged ≥65 years: updated recommendations of the Advisory Committee on Immunization Practices. MMWR Morb Mortal Wkly Rep. 2019 Nov 22;68(46):1069-75.Full text external link opens in a new windowAbstract external link opens in a new window

99. Seemungal T, Harper-Owen R, Bhowmik A, et al. Respiratory viruses, symptoms, and inflammatory markers in acute exacerbations and stable chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2001 Nov 1;164(9):1618-23.Abstract external link opens in a new window

100. Clancy R, Cripps A, Murree-Allen K, et al. Oral immunisation with killed Haemophilus influenzae for protection against acute bronchitis in chronic obstructive lung disease. Lancet. 1985 Dec 21-28;2(8469-70):1395-7.Abstract external link opens in a new window

101. Clancy RL, Cripps AW, Gebski V. Protection against recurrent acute bronchitis after oral immunization with killed Haemophilus influenzae. Med J Aust. 1990 Apr 16;152(8):413-6.Abstract external link opens in a new window

102. Lehmann D, Coakley KJ, Coakley CA, et al. Reduction in the incidence of acute bronchitis by an oral Haemophilus influenzae vaccine in patients with chronic bronchitis in the highlands of Papua New Guinea. Am Rev Respir Dis. 1991 Aug;144(2):324-30.Abstract external link opens in a new window

103. Tandon MK, Gebski V. A controlled trial of a killed Haemophilus influenzae vaccine for prevention of acute exacerbations of chronic bronchitis. Aust N Z J Med. 1991 Aug;21(4):427-32.Abstract external link opens in a new window

104. Tandon MK, Phillips M, Waterer G, et al. Oral immunotherapy with inactivated nontypeable Haemophilus influenzae reduces severity of acute exacerbations in severe COPD. Chest. 2010 Apr;137(4):805-11.Abstract external link opens in a new window

105. Teo E, Lockhart K, Purchuri SN, et al. Haemophilus influenzae oral vaccination for preventing acute exacerbations of chronic bronchitis and chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2017 Jun 19;(6):CD010010.Full text external link opens in a new windowAbstract external link opens in a new window

106. Brill SE, Wedzicha JA. Oxygen therapy in acute exacerbations of chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2014 Nov 7;9:1241-52.Full text external link opens in a new windowAbstract external link opens in a new window

107. Rodriguez-Roisin R. Toward a consensus definition for COPD exacerbations. Chest. 2000 May;117(5 Suppl 2):398S-401S.Abstract external link opens in a new window

108. Pauwels R, Calverley P, Buist AS, et al. COPD exacerbations: the importance of a standard definition. Respir Med. 2004 Feb;98(2):99-107.Abstract external link opens in a new window

109. Quon BS, Gan WQ, Sin DD, et al. Contemporary management of acute exacerbations of COPD: a systematic review and metaanalysis. Chest 2008 Mar;133(3):756-66.Abstract external link opens in a new window

110. Steer J, Gibson J, Bourke SC. The DECAF Score: predicting hospital mortality in exacerbations of chronic obstructive pulmonary disease. Thorax. 2012 Nov;67(11):970-6.Full text external link opens in a new windowAbstract external link opens in a new window

111. Echevarria C, Gray J, Hartley T, et al. Home treatment of COPD exacerbation selected by DECAF score: a non-inferiority, randomised controlled trial and economic evaluation. Thorax. 2018 Aug;73(8):713-22.Full text external link opens in a new windowAbstract external link opens in a new window

112. Schuetz P, Wirz Y, Sager R, et al. Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections. Cochrane Database Syst Rev. 2017 Oct 12;(10):CD007498.Full text external link opens in a new windowAbstract external link opens in a new window

113. Daubin C, Valette X, Thiollière F, et al. Procalcitonin algorithm to guide initial antibiotic therapy in acute exacerbations of COPD admitted to the ICU: a randomized multicenter study. Intensive Care Med. 2018 Apr;44(4):428-37.Full text external link opens in a new windowAbstract external link opens in a new window

114. Prins HJ, Duijkers R, van der Valk P, et al. CRP-guided antibiotic treatment in acute exacerbations of COPD in hospital admissions. Eur Respir J. 2019 May 23;53(5):1802014.Full text external link opens in a new windowAbstract external link opens in a new window

115. Butler CC, Gillespie D, White P, et al. C-Reactive protein testing to guide antibiotic prescribing for COPD exacerbations. N Engl J Med. 2019 Jul 11;381(2):111-20.Full text external link opens in a new windowAbstract external link opens in a new window

116. Francis NA, Gillespie D, White P, et al. C-reactive protein point-of-care testing for safely reducing antibiotics for acute exacerbations of chronic obstructive pulmonary disease: the PACE RCT. Health Technol Assess. 2020 Mar;24(15):1-108.Full text external link opens in a new windowAbstract external link opens in a new window

117. Bestall JC, Paul EA, Garrod R, et al. Usefulness of the Medical Research Council (MRC) dyspnoea scale as a measure of disability in patients with chronic obstructive pulmonary disease. Thorax. 1999 Jul;54(7):581-6.Abstract external link opens in a new window

118. Stockley RA, O'Brien C, Pye A, et al. Relationship of sputum color to nature and outpatient management of acute exacerbations of COPD. Chest. 2000 Jun;117(6):1638-45.Abstract external link opens in a new window

119. Gompertz S, O'Brien C, Bayley DL, et al. Changes in bronchial inflammation during acute exacerbations of chronic bronchitis. Eur Respir J. 2001 Jun;17(6):1112-9.Full text external link opens in a new windowAbstract external link opens in a new window

120. Huiart L, Ernst P, Suissa S. Cardiovascular morbidity and mortality in COPD. Chest. 2005 Oct;128(4):2640-6.Abstract external link opens in a new window

121. Lim BL, Kelly AM. A meta-analysis on the utility of peripheral venous blood gas analyses in exacerbations of chronic obstructive pulmonary disease in the emergency department. Eur J Emerg Med. 2010 Oct;17(5):246-8.Abstract external link opens in a new window

122. British Thoracic Society. BTS Guideline for oxygen use in healthcare and emergency settings. Oct 2017 [internet publication].Full text external link opens in a new window

123. Brekke PH, Omland T, Smith P, et al. Underdiagnosis of myocardial infarction in COPD - Cardiac Infarction Injury Score (CIIS) in patients hospitalised for COPD exacerbation. Respir Med. 2008 Sep;102(9):1243-7.Abstract external link opens in a new window

124. Gelow JM, Fang JC. Update in the approach to and management of heart failure. South Med J. 2006 Dec;99(12):1346-55.Abstract external link opens in a new window

125. Doust J, Lehman R, Glasziou P. The role of BNP testing in heart failure. Am Fam Physician. 2006 Dec 1;74(11):1893-8.Abstract external link opens in a new window

126. Mueller C, Scholer A, Laule-Kilian K, et al. Use of B-type natriuretic peptide in the evaluation and management of acute dyspnea. N Engl J Med. 2004 Feb 12;350(7):647-54.Full text external link opens in a new windowAbstract external link opens in a new window

127. Dewan NA. COPD exacerbations: to X-ray or not to X-ray. Chest. 2002 Oct;122(4):1118-21.Abstract external link opens in a new window

128. Emerman CL, Cydulka RK. Evaluation of high-yield criteria for chest radiography in acute exacerbation of chronic obstructive pulmonary disease. Ann Emerg Med. 1993 Apr;22(4):680-4.Abstract external link opens in a new window

129. Sherman S, Skoney JA, Ravikrishnan KP. Routine chest radiographs in exacerbations of chronic obstructive pulmonary disease. Diagnostic value. Arch Intern Med. 1989 Nov;149(11):2493-6.Abstract external link opens in a new window

130. Lieberman D, Lieberman D, Gelfer Y, et al. Pneumonic vs nonpneumonic acute exacerbations of COPD. Chest. 2002 Oct;122(4):1264-70.Abstract external link opens in a new window

131. Slater A, Goodwin M, Anderson KE, et al. COPD can mimic the appearance of pneumothorax on thoracic ultrasound. Chest. 2006 Mar;129(3):545-50.Abstract external link opens in a new window

132. Tillie-Leblond I, Marquette CH, Perez T, et al. Pulmonary embolism in patients with unexplained exacerbation of chronic obstructive pulmonary disease: prevalence and risk factors. Ann Intern Med. 2006 Mar 21;144(6):390-6.Abstract external link opens in a new window

133. Simonneau G, Gatzoulis MA, Adatia I, et al. Updated clinical classification of pulmonary hypertension. J Am Coll Cardiol. 2013 Dec 24;62(25 suppl):D34-41.Full text external link opens in a new windowAbstract external link opens in a new window

134. Robinson TD, Freiberg DB, Regnis JA, et al. The role of hypoventilation and ventilation-perfusion redistribution in oxygen-induced hypercapnia during acute exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2000 May;161(5):1524-9.Abstract external link opens in a new window

135. Santos C, Ferrer M, Roca J, et al. Pulmonary gas exchange response to oxygen breathing in acute lung injury. Am J Respir Crit Care Med. 2000 Jan;161(1):26-31.Abstract external link opens in a new window

136. Hanson CW, 3rd, Marshall BE, Frasch HF, et al. Causes of hypercarbia with oxygen therapy in patients with chronic obstructive pulmonary disease. Crit Care Med. 1996 Jan;24(1):23-8.Abstract external link opens in a new window

137. Veterans Affairs/Department of Defense. VA/DoD clinical practice guideline: the management of chronic obstructive pulmonary disease. Dec 2014 [internet publication].Full text external link opens in a new window

138. National Institute for Health and Care Excellence. Chronic obstructive pulmonary disease in over 16s: diagnosis and management. 2019 [internet publication].Full text external link opens in a new window

139. El Moussaoui R, Roede BM, Speelman P, et al. Short-course antibiotic treatment in acute exacerbations of chronic bronchitis and COPD: a meta-analysis of double-blind studies. Thorax. 2008;63:415-422.Abstract external link opens in a new window

140. WHO: package of essential noncommunicable (PEN) disease interventions for primary health care.

141. National Institute for Health and Care Excellence. Chronic obstructive pulmonary disease (acute exacerbation): antimicrobial prescribing. 2018 [internet publication].Full text external link opens in a new window

142. Stevenson NJ, Walker PP, Costello RW, et al. Lung mechanics and dyspnea during exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2005 Dec 15;172(12):1510-6.Abstract external link opens in a new window

143. Bach PB, Brown C, Gelfand SE, et al. Management of acute exacerbations of chronic obstructive pulmonary disease: a summary and appraisal of published evidence. Ann Intern Med. 2001 Apr 3;134(7):600-20.Abstract external link opens in a new window

144. Celli BR, MacNee W, Agusti A, et al; ATS/ERS Task Force. Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. Eur Respir J. 2004 Jun;23(6):932-46.Full text external link opens in a new windowAbstract external link opens in a new window

145. Turner MO, Patel A, Ginsburg S, et al. Bronchodilator delivery in acute airflow obstruction. A meta-analysis. Arch Intern Med. 1997 Aug 11-25;157(15):1736-44.Abstract external link opens in a new window

146. Karpel JP, Pesin J, Greenberg D, et al. A comparison of the effects of ipratropium bromide and metaproterenol sulfate in acute exacerbations of COPD. Chest. 1990 Oct;98(4):835-9.Abstract external link opens in a new window

147. Emerman CL, Cydulka RK. Effect of different albuterol dosing regimens in the treatment of acute exacerbation of chronic obstructive pulmonary disease. Ann Emerg Med. 1997 Apr;29(4):474-8.Abstract external link opens in a new window

148. Donohue JF, Hanania NA, Ciubotaru RL, et al. Comparison of levalbuterol and racemic albuterol in hospitalized patients with acute asthma or COPD: a 2-week, multicenter, randomized, open-label study. Clin Ther. 2008 Jan 1;30:989-1002.Abstract external link opens in a new window

149. Moayyedi P, Congleton J, Page RL, et al. Comparison of nebulised salbutamol and ipratropium bromide with salbutamol alone in the treatment of chronic obstructive pulmonary disease. Thorax. 1995 Aug;50(8):834-7.Full text external link opens in a new windowAbstract external link opens in a new window

150. Patrick DM, Dales RE, Stark RM, et al. Severe exacerbations of COPD and asthma: incremental benefit of adding ipratropium to usual therapy. Chest. 1990 Aug;98(2):295-7.Abstract external link opens in a new window

151. van Geffen WH, Douma WR, Slebos DJ, et al. Bronchodilators delivered by nebuliser versus pMDI with spacer or DPI for exacerbations of COPD. Cochrane Database Syst Rev. 2016 Aug 29;(8):CD011826.Full text external link opens in a new windowAbstract external link opens in a new window

152. Walters JA, Tan DJ, White CJ, et al. Systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2014 Sep 1;(9):CD001288.Full text external link opens in a new windowAbstract external link opens in a new window

153. de Jong YP, Uil SM, Grotjohan HP, et al. Oral or IV prednisolone in the treatment of COPD exacerbations: a randomized, controlled, double-blind study. Chest. 2007 Dec;132(6):1741-7.Abstract external link opens in a new window

154. Zheng J, Lin J, Zhou X, et al. Nebulized budesonide in the treatment of acute exacerbations of chronic obstructive pulmonary disease (AECOPD): a randomized, double blind, double dummy, parallel controlled, multicenter trial. Chest. 2011 Oct 23;140(4):526A.

155. Alía I, de la Cal MA, Esteban A, et al. Efficacy of corticosteroid therapy in patients with an acute exacerbation of chronic obstructive pulmonary disease receiving ventilatory support. Arch Intern Med. 2011 Nov 28;171(21):1939-46.Full text external link opens in a new windowAbstract external link opens in a new window

156. Aaron SD, Vandemheen KL, Fergusson D, et al. Tiotropium in combination with placebo, salmeterol, or fluticasone-salmeterol for treatment of chronic obstructive pulmonary disease: a randomized trial. Ann Intern Med. 2007 Apr 17;146(8):545-55.Full text external link opens in a new windowAbstract external link opens in a new window

157. Niewoehner DE, Erbland ML, Deupree RH, et al. Effect of systemic glucocorticoids on exacerbations of chronic obstructive pulmonary disease. Department of Veterans Affairs Cooperative Study Group. N Engl J Med. 1999 Jun 24;340(25):1941-7.Abstract external link opens in a new window

158. Walters JA, Walters EH, Wood-Baker R. Oral corticosteroids for stable chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2005 Jul 20;(3):CD005374.Abstract external link opens in a new window

159. Waljee AK, Rogers MA, Lin P, et al. Short term use of oral corticosteroids and related harms among adults in the United States: population based cohort study. BMJ. 2017 Apr 12;357:j1415.Full text external link opens in a new windowAbstract external link opens in a new window

160. Leuppi JD, Schuetz P, Bingisser R, et al. Short-term vs conventional glucocorticoid therapy in acute exacerbations of chronic obstructive pulmonary disease: the REDUCE randomized clinical trial. JAMA. 2013 Jun 5;309(21):2223-31.Full text external link opens in a new windowAbstract external link opens in a new window

161. Walters JA, Tan DJ, White CJ, et al. Different durations of corticosteroid therapy for exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2018 Mar 19;(3):CD006897.Full text external link opens in a new windowAbstract external link opens in a new window

162. Wedzicha JA Ers Co-Chair, Miravitlles M, Hurst JR, et al. Management of COPD exacerbations: a European Respiratory Society/American Thoracic Society guideline. Eur Respir J. 2017 Mar 15;49(3):1600791.Full text external link opens in a new windowAbstract external link opens in a new window

163. Bafadhel M, McKenna S, Terry S, et al. Blood eosinophils to direct corticosteroid treatment of exacerbations of chronic obstructive pulmonary disease: a randomized placebo-controlled trial. Am J Respir Crit Care Med. 2012 Jul 1;186(1):48-55.Full text external link opens in a new windowAbstract external link opens in a new window

164. Sivapalan P, Lapperre TS, Janner J, et al. Eosinophil-guided corticosteroid therapy in patients admitted to hospital with COPD exacerbation (CORTICO-COP): a multicentre, randomised, controlled, open-label, non-inferiority trial. Lancet Respir Med. 2019 Aug;7(8):699-709.Abstract external link opens in a new window

165. Abroug F, Ouanes-Besbes L, Fkih-Hassen M, et al. Prednisone in COPD exacerbation requiring ventilatory support: an open-label randomised evaluation. Eur Respir J. 2014 Mar;43(3):717-24.Abstract external link opens in a new window

166. Gaude GS, Nadagouda S. Nebulized corticosteroids in the management of acute exacerbation of COPD. Lung India. 2010 Oct;27(4):230-5.Full text external link opens in a new windowAbstract external link opens in a new window

167. Ding Z, Li X, Lu Y, et al. A randomized, controlled multicentric study of inhaled budesonide and intravenous methylprednisolone in the treatment on acute exacerbation of chronic obstructive pulmonary disease. Respir Med. 2016 Dec;121:39-47.Full text external link opens in a new windowAbstract external link opens in a new window

168. Husta BC, Raoof S, Erzurum S, et al. Tracheobronchopathy from inhaled corticosteroids. Chest. 2017 Dec;152(6):1296-1305.Full text external link opens in a new windowAbstract external link opens in a new window

169. Osadnik CR, McDonald CF, Jones AP, et al. Airway clearance techniques for chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2012 Mar 14;(3):CD008328.Full text external link opens in a new windowAbstract external link opens in a new window

170. Osadnik CR, McDonald CF, Miller BR, et al. The effect of positive expiratory pressure (PEP) therapy on symptoms, quality of life and incidence of re-exacerbation in patients with acute exacerbations of chronic obstructive pulmonary disease: a multicentre, randomised controlled trial. Thorax. 2014 Feb;69(2):137-43.Abstract external link opens in a new window

171. Tang CY, Taylor NF, Blackstock FC. Chest physiotherapy for patients admitted to hospital with an acute exacerbation of chronic obstructive pulmonary disease (COPD): a systematic review. Physiotherapy. 2010 Mar;96(1):1-13.Abstract external link opens in a new window

172. Hill K, Patman S, Brooks D. Effect of airway clearance techniques in patients experiencing an acute exacerbation of chronic obstructive pulmonary disease: a systematic review. Chron Respir Dis. 2010 Oct 9;7(1):9-17.Abstract external link opens in a new window

173. Cross J, Elender F, Barton G, et al. A randomised controlled equivalence trial to determine the effectiveness and cost-utility of manual chest physiotherapy techniques in the management of exacerbations of chronic obstructive pulmonary disease (MATREX). Health Technol Assess. 2010 May;14(23):1-147, iii-iv.Full text external link opens in a new windowAbstract external link opens in a new window

174. Austin MA, Wills KE, Blizzard L, et al. Effect of high flow oxygen on mortality in chronic obstructive pulmonary disease patients in prehospital setting: randomised controlled trial. BMJ. 2010 Oct 18;341:c5462.Full text external link opens in a new windowAbstract external link opens in a new window

175. Agusti AG, Carrera M, Barbe F, et al. Oxygen therapy during exacerbations of chronic obstructive pulmonary disease. Eur Respir J. 1999 Oct;14(4):934-9.Full text external link opens in a new windowAbstract external link opens in a new window

176. Roca O, Hernández G, Díaz-Lobato S, et al. Current evidence for the effectiveness of heated and humidified high flow nasal cannula supportive therapy in adult patients with respiratory failure. Crit Care. 2016 Apr 28;20(1):109.Full text external link opens in a new windowAbstract external link opens in a new window

177. Ram FS. Use of theophylline in chronic obstructive pulmonary disease: examining the evidence. Curr Opin Pulm Med. 2006 Mar;12(2):132-9.Abstract external link opens in a new window

178. Zhou Y, Wang X, Zeng X, et al. Positive benefits of theophylline in a randomized, double-blind, parallel-group, placebo-controlled study of low-dose, slow-release theophylline in the treatment of COPD for 1 year. Respirology. 2006 Sep;11(5):603-10.Abstract external link opens in a new window

179. Barr RG, Rowe BH, Camargo CA, Jr. Methylxanthines for exacerbations of chronic obstructive pulmonary disease: meta-analysis of randomised trials. BMJ. 2003 Sep 20;327(7416):643.Full text external link opens in a new windowAbstract external link opens in a new window

180. Saint S, Bent S, Vittinghoff E, et al. Antibiotics in chronic obstructive pulmonary disease exacerbations. A meta-analysis. JAMA. 1995 Mar 22-29;273(12):957-60.Abstract external link opens in a new window

181. Llor C, Moragas A, Hernández S, et al. Efficacy of antibiotic therapy for acute exacerbations of mild to moderate chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2012 Oct 15;186(8):716-23.Full text external link opens in a new windowAbstract external link opens in a new window

182. Vollenweider DJ, Frei A, Steurer-Stey CA, et al. Antibiotics for exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2018 Oct 29;10(10):CD010257.Full text external link opens in a new windowAbstract external link opens in a new window

183. El Moussaoui R, Roede BM, Speelman P, et al. Short-course antibiotic treatment in acute exacerbations of chronic bronchitis and COPD: a meta-analysis of double-blind studies. Thorax. 2008 May;63(5):415-22.Abstract external link opens in a new window

184. Falagas ME, Avgeri SG, Matthaiou DK, et al. Short- versus long-duration antimicrobial treatment for exacerbations of chronic bronchitis: a meta-analysis. J Antimicrob Chemother. 2008 Sep;62(3):442-50.Full text external link opens in a new windowAbstract external link opens in a new window

185. Stolbrink M, Amiry J, Blakey JD. Does antibiotic treatment duration affect the outcomes of exacerbations of asthma and COPD? A systematic review. Chron Respir Dis. 2018 Aug;15(3):225-40.Full text external link opens in a new windowAbstract external link opens in a new window

186. Lee RA, Centor RM, Humphrey LL, et al. Appropriate use of short-course antibiotics in common infections: best practice advice from the American College of Physicians. Ann Intern Med. 2021 Apr 6 [Epub ahead of print].Full text external link opens in a new windowAbstract external link opens in a new window

187. Wilson R, Allegra L, Huchon G, et al. Short-term and long-term outcomes of moxifloxacin compared to standard antibiotic treatment in acute exacerbations of chronic bronchitis. Chest. 2004 Mar;125(3):953-64.Abstract external link opens in a new window

188. Wilson R, Schentag JJ, Ball P, et al. A comparison of gemifloxacin and clarithromycin in acute exacerbations of chronic bronchitis and long-term clinical outcomes. Clin Ther. 2002 Apr;24(4):639-52.Abstract external link opens in a new window

189. Wilson R, Jones P, Schaberg T, et al. Antibiotic treatment and factors influencing short and long term outcomes of acute exacerbations of chronic bronchitis. Thorax. 2006 Apr;61(4):337-42.Abstract external link opens in a new window

190. Grossman RF, Ambrusz ME, Fisher AC, et al. Levofloxacin 750 mg QD for five days versus amoxicillin/clavulanate 875 mg/125 mg BID for ten days for treatment of acute bacterial exacerbation of chronic bronchitis: a post hoc analysis of data from severely ill patients. Clin Ther. 2006 Aug;28(8):1175-80.Abstract external link opens in a new window

191. Siempos II, Dimopoulos G, Korbila IP, et al. Macrolides, quinolones and amoxicillin/clavulanate for chronic bronchitis: a meta-analysis. Eur Respir J. 2007 Jun;29(6):1127-37.Abstract external link opens in a new window

192. Dimopoulos G, Siempos, II, Korbila IP, et al. Comparison of first-line with second-line antibiotics for acute exacerbations of chronic bronchitis: a meta-analysis of randomized controlled trials. Chest. 2007 Aug;132(2):447-55.Abstract external link opens in a new window

193. Korbila IP, Manta KG, Siempos II, et al. Penicillins vs trimethoprim-based regimens for acute bacterial exacerbations of chronic bronchitis: meta-analysis of randomized controlled trials. Can Fam Physician. 2009 Jan;55(1):60-7.Full text external link opens in a new windowAbstract external link opens in a new window

194. Vermeersch K, Gabrovska M, Aumann J, et al. Azithromycin during acute chronic obstructive pulmonary disease exacerbations requiring hospitalization (BACE). A multicenter, randomized, double-blind, placebo-controlled trial. Am J Respir Crit Care Med. 2019 Oct 1;200(7):857-68.Full text external link opens in a new windowAbstract external link opens in a new window

195. European Medicines Agency. Quinolone- and fluoroquinolone-containing medicinal products. Mar 2019 [internet publication].Full text external link opens in a new window

196. Medicines and Healthcare products Regulatory Agency. Fluoroquinolone antibiotics: new restrictions and precautions for use due to very rare reports of disabling and potentially long-lasting or irreversible side effects. Mar 2019 [internet publication].Full text external link opens in a new window

197. FDA Drug Safety Communication: FDA advises restricting fluoroquinolone antibiotic use for certain uncomplicated infections; warns about disabling side effects that can occur together. Dec 2016 [internet publication].Full text external link opens in a new window

198. US Food and Drug Administration. FDA Drug Safety Communication. FDA warns about increased risk of ruptures or tears in the aorta blood vessel with fluoroquinolone antibiotics in certain patients. Dec 2018 [internet publication].Full text external link opens in a new window

199. US Food and Drug Administration. FDA Drug Safety Communication. FDA reinforces safety information about serious low blood sugar levels and mental health side effects with fluoroquinolone antibiotics; requires label changes. Jul 2018 [internet publication].Full text external link opens in a new window

200. Osadnik CR, Tee VS, Carson-Chahhoud KV, et al. Non-invasive ventilation for the management of acute hypercapnic respiratory failure due to exacerbation of chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2017 Jul 13;(7):CD004104.Full text external link opens in a new windowAbstract external link opens in a new window

201. Keenan SP, Sinuff T, Burns KE, et al. Clinical practice guidelines for the use of noninvasive positive-pressure ventilation and noninvasive continuous positive airway pressure in the acute care setting. CMAJ. 2011 Feb 22;183(3):E195-214.Full text external link opens in a new windowAbstract external link opens in a new window

202. Barreiro TJ, Gemmel DJ. Noninvasive ventilation. Crit Care Clin. 2007 Apr;23(2):201-22, ix.Abstract external link opens in a new window

203. Roberts CM, Brown JL, Reinhardt AK, et al. Non-invasive ventilation in chronic obstructive pulmonary disease: management of acute type 2 respiratory failure. Clin Med. 2008 Oct;8(5):517-21.Abstract external link opens in a new window

204. Smith TA, Davidson PM, Lam LT, et al. The use of non-invasive ventilation for the relief of dyspnoea in exacerbations of chronic obstructive pulmonary disease; a systematic review. Respirology. 2012 Feb;17(2):300-7.Abstract external link opens in a new window

205. Anton A, Guell R, Gomez J, et al. Predicting the result of noninvasive ventilation in severe acute exacerbations of patients with chronic airflow limitation. Chest. 2000 Mar;117(3):828-33.Abstract external link opens in a new window

206. Koh Y. Ventilatory management in patients with chronic airflow obstruction. Crit Care Clin. 2007 Apr;23(2):169-81.Abstract external link opens in a new window

207. Chandra D, Stamm JA, Taylor B, et al. Outcomes of noninvasive ventilation for acute exacerbations of chronic obstructive pulmonary disease in the United States, 1998-2008. Am J Respir Crit Care Med. 2012 Jan 15;185(2):152-9.Full text external link opens in a new windowAbstract external link opens in a new window

208. Breen D, Churches T, Hawker F, et al. Acute respiratory failure secondary to chronic obstructive pulmonary disease treated in the intensive care unit: a long term follow up study. Thorax. 2002 Jan;57(1):29-33.Full text external link opens in a new windowAbstract external link opens in a new window

209. McCurdy BR. Noninvasive positive pressure ventilation for acute respiratory failure patients with chronic obstructive pulmonary disease (COPD): an evidence-based analysis. Ont Health Technol Assess Ser. 2012;12(8):1-102.Full text external link opens in a new windowAbstract external link opens in a new window

210. Udwadia ZF, Santis GK, Steven MH, et al. Nasal ventilation to facilitate weaning in patients with chronic respiratory insufficiency. Thorax. 1992 Sep;47(9):715-8.Abstract external link opens in a new window

211. Soar J, Böttiger BW, Carli P, et al. European Resuscitation Council Guidelines 2021: adult advanced life support. Resuscitation. 2021 Apr;161:115-51.Full text external link opens in a new windowAbstract external link opens in a new window

212. Colquhoun MC, Handley AJ, Evans TR. ABC of resuscitation. 5th ed. London: BMJ Publishing Group; 2004.

213. Soar J, Böttiger BW, Carli P, et al. European Resuscitation Council Guidelines 2021: adult advanced life support. Resuscitation. 2021 Apr;161:115-51.Full text external link opens in a new windowAbstract external link opens in a new window

214. Man WD, Soliman MG, Nikoletou D, et al. Non-volitional assessment of skeletal muscle strength in patients with chronic obstructive pulmonary disease. Thorax. 2003 Aug;58(8):665-9.Abstract external link opens in a new window

215. Spruit MA, Gosselink R, Troosters T, et al. Muscle force during an acute exacerbation in hospitalised patients with COPD and its relationship with CXCL8 and IGF-I. Thorax. 2003 Sep;58(9):752-6.Full text external link opens in a new windowAbstract external link opens in a new window

216. Rice KL, Dewan N, Bloomfield HE, et al. Disease management program for chronic obstructive pulmonary disease: a randomized controlled trial. Am J Respir Crit Care Med. 2010 Oct 1;182(7):890-6.Abstract external link opens in a new window

217. Spruit MA, Singh SJ, Garvey C, et al. An official American Thoracic Society/European Respiratory Society statement: key concepts and advances in pulmonary rehabilitation. Am J Respir Crit Care Med. 2013 Oct 15;188(8):e13-64.Abstract external link opens in a new window

218. Zanotti E, Felicetti G, Maini M, et al. Peripheral muscle strength training in bed-bound patients with COPD receiving mechanical ventilation: effect of electrical stimulation. Chest. 2003 Jul;124(1):292-6.Abstract external link opens in a new window

219. Troosters T, Probst VS, Crul T, et al. Resistance training prevents deterioration in quadriceps muscle function during acute exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2010 May 15;181(10):1072-7.Abstract external link opens in a new window

220. Reid WD, Yamabayashi C, Goodridge D, et al. Exercise prescription for hospitalized people with chronic obstructive pulmonary disease and comorbidities: a synthesis of systematic reviews. Int J Chron Obstruct Pulmon Dis. 2012 May;7:297-320.Full text external link opens in a new windowAbstract external link opens in a new window

221. Man WD, Polkey MI, Donaldson N, et al. Community pulmonary rehabilitation after hospitalisation for acute exacerbations of chronic obstructive pulmonary disease: randomised controlled study. BMJ. 2004 Nov 20;329(7476):1209.Full text external link opens in a new windowAbstract external link opens in a new window

222. Clini EM, Crisafulli E, Costi S, et al. Effects of early inpatient rehabilitation after acute exacerbation of COPD. Respir Med. 2009 Oct;103(10):1526-31.Abstract external link opens in a new window

223. Marciniuk DD, Brooks D, Butcher S, et al. Canadian Thoracic Society COPD Committee Expert Working Group. Optimizing pulmonary rehabilitation in chronic obstructive pulmonary disease practical issues: a Canadian Thoracic Society Clinical Practice Guideline. Can Respir J. 2010 Jul;17(4):159-68.Abstract external link opens in a new window

224. Seymour JM, Moore L, Jolley CJ, et al. Outpatient pulmonary rehabilitation following acute exacerbations of COPD. Thorax. 2010 May;65(5):423-8.Abstract external link opens in a new window

225. Puhan MA, Gimeno-Santos E, Cates CJ, Troosters T. Pulmonary rehabilitation following exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2016 Dec 8;(12):CD005305.Full text external link opens in a new windowAbstract external link opens in a new window

226. Langer D, Hendriks E, Burtin C, et al. A clinical practice guideline for physiotherapists treating patients with chronic obstructive pulmonary disease based on a systematic review of available evidence. Clin Rehabil. 2009 May;23(5):445-62.Abstract external link opens in a new window

227. Maltais F, Bourbeau J, Shapiro S, et al. Effects of home-based pulmonary rehabilitation in patients with chronic obstructive pulmonary disease: a randomized trial. Ann Intern Med. 2008 Dec 16;149(12):869-78.Abstract external link opens in a new window

228. Tang CY, Blackstock FC, Clarence M, et al. Early rehabilitation exercise program for inpatients during an acute exacerbation of chronic obstructive pulmonary disease: a randomized controlled trial. J Cardiopulm Rehabil Prev. 2012 May-Jun;32(3):163-9.Abstract external link opens in a new window

229. Puhan MA, Scharplatz M, Troosters T, et al. Respiratory rehabilitation after acute exacerbation of COPD may reduce risk for readmission and mortality--a systematic review. Respir Res. 2005 Jun 8;6(1):54.Full text external link opens in a new windowAbstract external link opens in a new window

230. Lindenauer PK, Stefan MS, Pekow PS, et al. Association between initiation of pulmonary rehabilitation after hospitalization for COPD and 1-year survival among medicare beneficiaries. JAMA. 2020 May 12;323(18):1813-23.Full text external link opens in a new windowAbstract external link opens in a new window

231. Greening NJ, Williams JE, Hussain SF, et al. An early rehabilitation intervention to enhance recovery during hospital admission for an exacerbation of chronic respiratory disease: randomised controlled trial. BMJ. 2014 Jul 8;349:g4315.Full text external link opens in a new windowAbstract external link opens in a new window

232. Bourbeau J, Julien M, Maltais F, Rouleau M, et al. Reduction of hospital utilization in patients with chronic obstructive pulmonary disease: a disease-specific self-management intervention. Arch Intern Med. 2003 Mar 10;163(5):585-91.Full text external link opens in a new windowAbstract external link opens in a new window

233. Casas A, Troosters T, Garcia-Aymerich J, et al. Integrated care prevents hospitalisations for exacerbations in COPD patients. Eur Respir J. 2006 Jul;28(1):123-30.Full text external link opens in a new windowAbstract external link opens in a new window

234. Kuo CC, Lin CC, Lin SY, et al. Effects of self-regulation protocol on physiological and psychological measures in patients with chronic obstructive pulmonary disease. J Clin Nurs. 2013 Oct;22(19-20):2800-11.Abstract external link opens in a new window

235. Fan VS, Gaziano M, Lew R, et al. A comprehensive care management program to prevent chronic obstructive pulmonary disease hospitalizations: a randomized, controlled trial. Ann Intern Med. 2012 May 15;156(10):673-83.Abstract external link opens in a new window

236. Jeppesen E, Brurberg KG, Vist GE, et al. Hospital at home for acute exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2012 May 16;(5):CD003573.Full text external link opens in a new windowAbstract external link opens in a new window

237. McCurdy BR. Hospital-at-home programs for patients with acute exacerbations of chronic obstructive pulmonary disease (COPD): an evidence-based analysis. Ont Health Technol Assess Ser. 2012 Mar;12(10):1-65.Full text external link opens in a new windowAbstract external link opens in a new window

238. Vitacca M, Bianchi L, Guerra A, et al. Tele-assistance in chronic respiratory failure patients: a randomised clinical trial. Eur Respir J. 2009 Feb;33(2):411-8.Abstract external link opens in a new window

239. Pinnock H, Hanley J, McCloughan L, et al. Effectiveness of telemonitoring integrated into existing clinical services on hospital admission for exacerbation of chronic obstructive pulmonary disease: researcher blind, multicentre, randomised controlled trial. BMJ. 2013 Oct 17;347:f6070.Full text external link opens in a new windowAbstract external link opens in a new window

240. Holland A, Smith F, Penny K, et al. Metered dose inhalers versus nebulizers for aerosol bronchodilator delivery for adult patients receiving mechanical ventilation in critical care units. Cochrane Database Syst Rev. 2013 Jun 6;2013(6):CD008863.Full text external link opens in a new windowAbstract external link opens in a new window

241. American College of Radiology. ACR appropriateness criteria: acute respiratory illness in immunocompetent patients. 2013 [internet publication].Full text external link opens in a new window

242. Siu AL, Bibbins-Domingo K, Grossman DC, et al; US Preventive Services Task Force (USPSTF). Screening for Chronic Obstructive Pulmonary Disease: US Preventive Services Task Force Recommendation Statement. JAMA. 2016 Apr 5;315(13):1372-7.Full text external link opens in a new windowAbstract external link opens in a new window

243. O'Donnell DE, Hernandez P, Kaplan A, et al. Canadian Thoracic Society recommendations for management of chronic obstructive pulmonary disease - 2008 update - highlights for primary care. Can Respir J. 2008 Jan-Feb;15(suppl A):1A-8A.Full text external link opens in a new windowAbstract external link opens in a new window

244. Ries AL, Bauldoff GS, Carlin BW, et al. Pulmonary rehabilitation: joint ACCP/AACVPR evidence-based clinical practice guidelines. Chest. 2007 May;131(suppl 5):4S-42S.Full text external link opens in a new windowAbstract external link opens in a new window

245. McCool FD, Rosen MJ. Nonpharmacologic airway clearance therapies: ACCP evidence-based clinical practice guidelines. Chest. 2006 Jan;129(suppl 1):250S-259S.Full text external link opens in a new windowAbstract external link opens in a new window

246. Bolser DC. Cough suppressant and pharmacologic protussive therapy: ACCP evidence-based clinical practice guidelines. Chest. 2006 Jan;129(suppl 1):238S-249S.Full text external link opens in a new windowAbstract external link opens in a new window

247. Braman SS. Chronic cough due to chronic bronchitis: ACCP evidence-based clinical practice guidelines. Chest. 2006 Jan;129(suppl 1):104S-115S.Full text external link opens in a new windowAbstract external link opens in a new window

248. Wedzicha JA, Miravitlles M, Hurst JR, et al. Management of COPD exacerbations: a European Respiratory Society/American Thoracic Society guideline. Eur Respir J. 2017 Mar 15;49(3):1600791.Full text external link opens in a new windowAbstract external link opens in a new window

249. Wedzicha JA, Calverley PM, Albert RK, et al. Prevention of COPD exacerbations: a European Respiratory Society/American Thoracic Society guideline. Eur Respir J. 2017 Sep 9;50(3):1602265.Full text external link opens in a new windowAbstract external link opens in a new window

250. Rochester CL, Vogiatzis I, Holland AE, et al; ATS/ERS Task Force on Policy in Pulmonary Rehabilitation. An Official American Thoracic Society/European Respiratory Society Policy Statement: enhancing implementation, use, and delivery of pulmonary rehabilitation. Am J Respir Crit Care Med. 2015 Dec 1;192(11):1373-86.Full text external link opens in a new windowAbstract external link opens in a new window

251. Patil SP, Krishnan JA, Lechtzin N, et al. In-hospital mortality following acute exacerbations of chronic obstructive pulmonary disease. Arch Intern Med. 2003 May 26;163(10):1180-6.Full text external link opens in a new windowAbstract external link opens in a new window

252. Hoogendoorn M, Hoogenveen RT, Rutten-van Mölken MP, et al. Case fatality of COPD exacerbations: a meta-analysis and statistical modelling approach. Eur Respir J. 2011 Mar;37(3):508-15.Full text external link opens in a new windowAbstract external link opens in a new window

253. Dewan NA, Rafique S, Kanwar B, et al. Acute exacerbation of COPD: factors associated with poor treatment outcome. Chest. 2000 Mar;117(3):662-71.Abstract external link opens in a new window

254. Gunen H, Hacievliyagil SS, Kosar F, et al. Factors affecting survival of hospitalised patients with COPD. Eur Respir J. 2005 Aug;26(2):234-41.Full text external link opens in a new windowAbstract external link opens in a new window

255. Garcia-Aymerich J, Farrero E, Felez MA, et al. Risk factors of readmission to hospital for a COPD exacerbation: a prospective study. Thorax. 2003 Feb;58(2):100-5.Full text external link opens in a new windowAbstract external link opens in a new window

256. Garcia-Aymerich J, Lange P, Benet M, et al. Regular physical activity reduces hospital admission and mortality in chronic obstructive pulmonary disease: a population based cohort study. Thorax. 2006 Sep;61(9):772-8.Full text external link opens in a new windowAbstract external link opens in a new window

257. Piquet J, Chavaillon JM, David P, et al. High-risk patients following hospitalisation for an acute exacerbation of COPD. Eur Respir J. 2013 Oct;42(4):946-55.Full text external link opens in a new windowAbstract external link opens in a new window

258. Singanayagam A, Schembri S, Chalmers JD. Predictors of mortality in hospitalized adults with acute exacerbation of chronic obstructive pulmonary disease. Ann Am Thorac Soc. 2013 Apr;10(2):81-9.Full text external link opens in a new windowAbstract external link opens in a new window

259. Almagro P, Soriano JB, Cabrera FJ, et al. Short- and medium-term prognosis in patients hospitalized for COPD exacerbation: the CODEX index. Chest. 2014 May;145(5):972-80.Abstract external link opens in a new window

260. Sharma G, Kuo YF, Freeman JL, et al. Outpatient follow-up visit and 30-day emergency department visit and readmission in patients hospitalized for chronic obstructive pulmonary disease. Arch Intern Med. 2010;170:1664-1670.Full text external link opens in a new windowAbstract external link opens in a new window

261. Jones PW, Lamarca R, Chuecos F, et al. Characterisation and impact of reported and unreported exacerbations: results from ATTAIN. Eur Respir J. 2014 Nov;44(5):1156-65.Full text external link opens in a new windowAbstract external link opens in a new window

262. Mularski RA, Reinke LF, Carrieri-Kohlman V, et al. An official American Thoracic Society workshop report: assessment and palliative management of dyspnea crisis. Ann Am Thorac Soc. 2013 Oct;10(5):S98-106.Full text external link opens in a new windowAbstract external link opens in a new window

263. Jolliffe DA, Greenberg L, Hooper RL, et al. Vitamin D to prevent exacerbations of COPD: systematic review and meta-analysis of individual participant data from randomised controlled trials. Thorax. 2019 Apr;74(4):337-45.Full text external link opens in a new windowAbstract external link opens in a new window

264. Gross N, Levin D. Primary care of the patient with chronic obstructive pulmonary disease-part 2: pharmacologic treatment across all stages of disease. Am J Med. 2008 Jul;121(7 suppl):S13-24.Abstract external link opens in a new window

265. Sorensen SV, Baker T, Fleurence R, et al. Cost and clinical consequence of antibiotic non-adherence in acute exacerbations of chronic bronchitis. Int J Tuberc Lung Dis. 2009 Aug;13(8):945-54.Abstract external link opens in a new window

266. Lodewijckx C, Sermeus W, Vanhaecht K, et al. Inhospital management of COPD exacerbations: a systematic review of the literature with regard to adherence to international guidelines. J Eval Clin Pract. 2009 Dec;15(6):1101-10.Abstract external link opens in a new window

267. Ghosh S, Ohar JA, Drummond MB. Peak inspiratory flow rate in chronic obstructive pulmonary disease: implications for dry powder inhalers. J Aerosol Med Pulm Drug Deliv. 2017 Dec;30(6):381-7.Full text external link opens in a new windowAbstract external link opens in a new window

268. Pitta F, Troosters T, Probst VS, et al. Physical activity and hospitalization for exacerbation of COPD. Chest. 2006 Mar;129(3):536-44.Abstract external link opens in a new window

269. Garcia-Aymerich J, Lange P, Benet M, et al. Regular physical activity modifies smoking-related lung function decline and reduces risk of chronic obstructive pulmonary disease: a population-based cohort study. Am J Respir Crit Care Med. 2007 Mar 1;175(5):458-63.Abstract external link opens in a new window

270. Cindy Ng LW, Mackney J, Jenkins S, et al. Does exercise training change physical activity in people with COPD? A systematic review and meta-analysis. Chron Respir Dis. 2012 Feb;9(1):17-26.Abstract external link opens in a new window

271. COPD Working Group. Pulmonary rehabilitation for patients with chronic pulmonary disease (COPD): an evidence-based analysis. Ont Health Technol Assess Ser. 2012 Mar;12(6):1-75.Full text external link opens in a new windowAbstract external link opens in a new window

272. Sharma G, Kuo YF, Freeman JL, et al. Outpatient follow-up visit and 30-day emergency department visit and readmission in patients hospitalized for chronic obstructive pulmonary disease. Arch Intern Med. 2010 Oct 11;170(18):1664-70.Full text external link opens in a new windowAbstract external link opens in a new window

273. Howcroft M, Walters EH, Wood-Baker R, Walters JA. Action plans with brief patient education for exacerbations in chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2016 Dec 19;(12):CD005074.Full text external link opens in a new windowAbstract external link opens in a new window

274. Bucknall CE, Miller G, Lloyd SM, et al. Glasgow supported self-management trial (GSuST) for patients with moderate to severe COPD: randomised controlled trial. BMJ. 2012 Mar 6;344:e1060.Full text external link opens in a new windowAbstract external link opens in a new window

275. Harrison SL, Janaudis-Ferreira T, Brooks D, et al. Self-management following an acute exacerbation of COPD: a systematic review. Chest. 2015 Mar;147(3):646-61.Abstract external link opens in a new window

276. McLean S, Nurmatov U, Liu JL, et al. Telehealthcare for chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2011 Jul 6;(7):CD007718.Full text external link opens in a new windowAbstract external link opens in a new window

277. Bhatt SP, Patel SB, Anderson EM, et al. Video telehealth pulmonary rehabilitation intervention in chronic obstructive pulmonary disease reduces 30-day readmissions. Am J Respir Crit Care Med. 2019 Aug 15;200(4):511-13.Full text external link opens in a new windowAbstract external link opens in a new window

278. Franek J. Home telehealth for patients with chronic obstructive pulmonary disease (COPD): an evidence-based analysis. Ont Health Technol Assess Ser. 2012 Mar;12(11):1-58.Full text external link opens in a new windowAbstract external link opens in a new window