Differentials
Congestive heart failure
SIGNS / SYMPTOMS
Patients with systolic left-sided or biventricular congestive heart failure will often have a history consistent with heart failure. Underlying diastolic heart failure is often under-recognized.
Physical examination may note signs consistent with heart failure, such as an elevated jugular venous pressure, extra heart sounds, coarse breath sounds with crackles above the lung bases, wheezing, and dependent pitting edema.[137] It may be difficult to distinguish systolic or diastolic heart failure from an acute exacerbation of COPD. Notably, heart failure can lead to increased work of breathing, and result in acute respiratory failure that may or may not be superimposed on chronic respiratory failure.
Pneumonia
SIGNS / SYMPTOMS
Many aspects of acute exacerbations of COPD, including dyspnea, cough, and sputum production may be found in patients with pneumonia and it is often not possible to differentiate without chest imaging.
About 10% to 15% of patients presenting with an apparent acute exacerbation are found to have pneumonia, or other abnormalities, defined by chest imaging.[140][141][142] Patients with pneumonia have in general been found to experience higher fevers, more acute onset of illness, and somewhat greater severity of acute illness when compared with COPD patients without pneumonia.[140][143] The presence of pneumonia as a cause of respiratory decompensation in a patient with COPD does not necessarily imply the presence of a COPD exacerbation per se (i.e., the presence of worsened airflow limitation related to airways inflammation and/or bronchoconstriction), and as such careful consideration should be given as to whether systemic corticosteroids are warranted in such patients.
INVESTIGATIONS
Chest imaging in patients with pneumonia should identify changes consistent with an infiltrative process in the lung parenchyma.
Pleural effusion
SIGNS / SYMPTOMS
Pleural effusions may exacerbate dyspnea in patients with COPD. Physical examination may demonstrate decreased or absent breath sounds with dullness to percussion related to a pleural effusion.
INVESTIGATIONS
Chest imaging is recommended.
Pneumothorax
SIGNS / SYMPTOMS
Patients with COPD found to have pneumothoraces may or may not have additional signs or symptoms suggestive of a respiratory tract infection, but their presentation may closely mirror that of an acute exacerbation. Decreased breath sounds may be identified on the affected side and tracheal deviation away from the affected side and/or hypotension may be present in patients with a tension pneumothorax.
INVESTIGATIONS
Chest imaging is recommended to exclude a possible pneumothorax in patients with more than mild episodes.[144]
Pulmonary embolism
SIGNS / SYMPTOMS
Clinically, pulmonary embolism may present with signs and symptoms similar to an acute exacerbation of COPD, and the two are difficult to distinguish.[145] Pulmonary embolism should be considered as a cause of the acute symptoms if no other identifiable trigger for the exacerbation is evident. People with prior thromboembolic disease or underlying malignancy may be at particular risk.[145]
A low systolic blood pressure and/or the inability to increase the PaO2 to >60 mmHg with oxygen may indicate the presence of a pulmonary embolism.
INVESTIGATIONS
Computed tomographic pulmonary angiography (CTPA) will show direct visualization of thrombus in a pulmonary artery.
Elevation of D-dimer (may also be raised in COPD).[146]
ECG may show evidence of right ventricular dysfunction; however, ECG cannot definitively establish or eliminate pulmonary embolism as a diagnosis.[147][148][149]
Pulmonary hypertension
SIGNS / SYMPTOMS
People with pulmonary hypertension of various etiologies typically experience dyspnea and may have hypoxemia.[150] Symptoms of pulmonary hypertension may overlap with those of COPD, and some individuals with COPD have concurrent pulmonary hypertension. Worsening pulmonary hypertension can lead to decompensation of heart failure, particularly right heart failure.
INVESTIGATIONS
The presence of pulmonary hypertension may be identified by echocardiogram. A multifaceted evaluation may be needed to determine the cause(s). A right heart catheterization may be needed for diagnosis and to guide optimal management in some cases.
Cardiac ischemia
SIGNS / SYMPTOMS
Clinically, may be difficult to distinguish. Chest pain may be more apparent, with radiation down left side. Nausea, jaw pain, and/or diaphoresis may be present.
INVESTIGATIONS
An electrocardiogram should be performed, especially for patients who may require hospitalization for care of an acute exacerbation of COPD, to identify possible cardiac ischemia and arrhythmias.[1]
Cardiac arrhythmia
SIGNS / SYMPTOMS
Differentiating features may include palpitations, lightheadedness, loss of consciousness, and/or collapse.
INVESTIGATIONS
An electrocardiogram should be performed, especially for patients who may require hospitalization for care of an acute exacerbation of COPD or who are experiencing palpitations or dizziness, to identify possible cardiac ischemia and arrhythmias.[1]
Upper airway obstruction
SIGNS / SYMPTOMS
Large airway obstruction typically presents with dyspnea and wheeze (particularly during exertion and with forced exhalation maneuver), and it is commonly mistaken for refractory exacerbations of COPD; variable intrathoracic upper airway obstruction is often caused by tracheobronchomalacia, an aspirated object, or central airway tumor; variable extrathoracic upper airway obstruction is commonly caused by vocal cord paralysis, as well as by inflammation and swelling of the perilaryngeal soft tissues and intermittent vocal cord spasm associated with GERD, undiagnosed or untreated obstructive sleep apnea, and chronic post nasal drip; fixed upper airway obstruction may be caused by tracheal stenosis (e.g., due to prior intubation for mechanical ventilation), extrinsic compression of central airways (e.g., lymphadenopathy or mass), or large airway tumor. Auscultation over the larynx, trachea, and main bronchi during both quiet breathing and forced exhalation or hyperpnea maneuver should be done to evaluate for the presence of upper airway obstruction; complete resolution of wheezing during resting quiet breathing that is present during exertion or a forced exhalation maneuver argues against the presence of bronchoconstriction related to COPD exacerbation.
INVESTIGATIONS
Spirometry with flow volume loop can identify the presence of upper airway obstruction; when tracheobronchomalacia is suspected, CT scanning with inspiration and expiration views or direct bronchoscopic airway inspection can be diagnostic. Ear, nose, and throat evaluation may be considered for inspection of the vocal cords and perilaryngeal soft tissues.
Excessive oxygen therapy
SIGNS / SYMPTOMS
While oxygen therapy is clearly indicated for many patients with COPD and acute exacerbations (and should be titrated to achieve an oxygen saturation of 88%-92%), excessive oxygen leads to further degradation of the patient's respiratory physiology. Exposure to oxygen leads to decrease of hypoxic vasoconstriction of arteries supplying poorly ventilated spaces, increasing the degree of V/Q mismatch and/or intrapulmonary shunt.[151][152] An excess of oxygen may also decrease the capacity of erythrocytes to carry CO2 (Haldane effect).[153] These changes may then result in worsening of the patient's hypercarbia and respiratory acidosis. Selected patients with impaired respiratory drive may also develop worsening hypercarbia.
INVESTIGATIONS
An ABG should be performed for patients who are hypoxemic or are receiving oxygen therapy who present with an apparent acute exacerbation of COPD.
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