Type 2 diabetes mellitus in adults

The cornerstone of therapy for all patients with diabetes is a personalized self-management program, usually developed with the patient by a diabetes education nurse or nutritionist.

Lifestyle changes plus metformin are initial antihyperglycemic therapy for most patients. Glycemic goals and treatment choices are individualized.

Selected glucose-lowering drugs reduce all-cause and cardiovascular mortality. Addition of a sodium-glucose co-transporter 2 (SGLT2) inhibitor or glucagon-like peptide-1 (GLP-1) agonist is recommended in patients with longstanding suboptimal glycemic control plus established cardiovascular and/or renal disease.

Blood pressure control, lipid management, smoking cessation, and glycemic management reduce the risk of macrovascular complications such as heart attack and stroke. Glycemic control and blood pressure management reduce the risk of microvascular complications (neuropathy, nephropathy, retinopathy).

Type 2 diabetes mellitus is a progressive disorder defined by deficits in insulin secretion and action that lead to abnormal glucose metabolism and related metabolic derangements.[1]Meigs JB, Muller DC, Nathan DM, et al. The natural history of progression from normal glucose tolerance to type 2 diabetes in the Baltimore Longitudinal Study of Aging. Diabetes. 2003 Jun;52(6):1475-84. https://diabetes.diabetesjournals.org/content/52/6/1475.full http://www.ncbi.nlm.nih.gov/pubmed/12765960?tool=bestpractice.com Although the etiologies of type 1 and type 2 diabetes differ dramatically, both lead to hyperglycemic states, and both share common macrovascular (coronary heart, cerebrovascular, and peripheral vascular disease) and microvascular (retinopathy, nephropathy, and neuropathy) complications. Type 2 diabetes is most often diagnosed following routine screening. It is preceded by a state of prediabetes, which is defined by a single fasting plasma glucose of 100-125 mg/dL or a HbA1c of 5.7% to 6.4% in the absence of diabetes. Diabetes diagnosis is based on two confirmed values of: fasting plasma glucose >125 mg/dL; HbA1c of 6.5% or greater; or (less commonly) glucose tolerance test results, or a random plasma glucose of ≥200 mg/dL plus symptoms of hyperglycemia. A single blood sample is sufficient to establish a diabetes diagnosis if assays of both HbA1c and fasting plasma glucose meet criteria for diabetes diagnosis.[2]American Diabetes Association. Standards of medical care in diabetes - 2019. Diabetes Care. 2019;42(Suppl 1):S1-193. https://care.diabetesjournals.org/content/42/Supplement_1