Poliovirus infection

Drug therapy

While some existing medications appear to help with paralytic poliomyelitis and/or postpoliomyelitis syndrome, such as pyridostigmine, corticosteroids, amantadine, lamotrigine, and others, there have been an insufficient number of randomized clinical trials to fully recommend the use of these agents.[51]Koopman FS, Beelan A, Gilhus NE, et al. Treatment for postpolio syndrome. Cochrane Database Syst Rev. 2015 May 18;(5):CD007818. http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD007818.pub3/full http://www.ncbi.nlm.nih.gov/pubmed/25984923?tool=bestpractice.com [52]Farbu E. Update on current and emerging treatment options for post-polio syndrome. Ther Clin Risk Manag. 2010 Jul 21;6:307-13. https://www.dovepress.com/articles.php?article_id=4784 http://www.ncbi.nlm.nih.gov/pubmed/20668713?tool=bestpractice.com ​ Treatment with immune gamma globulin from recovered poliomyelitis patients has been previously reported, with some promise.[53]Hammon WM, Coriell LL, Ludwig EH, et al. Evaluation of Red Cross gamma globulin as a prophylactic agent for poliomyelitis. 5. Reanalysis of results based on laboratory-confirmed cases. J Am Med Assoc. 1954 Sep 4;156(1):21-7. http://www.ncbi.nlm.nih.gov/pubmed/13183798?tool=bestpractice.com Due to a variety of limitations, further development was halted in favor of effective vaccination with oral attenuated poliovirus vaccine (OPV) (Sabin) and inactivated poliovirus vaccine (IPV) (Salk).