Constipation

Overview 
Theory 
Diagnosis 
Management 
Follow up 
Resources 

Last reviewed: 10 Aug 2024

Last updated: 17 Apr 2024

Constipation is initially evaluated with a detailed history and physical examination, including a digital rectal examination.

Diagnostic evaluation may include a colonoscopy if indicated, colonic transit study, anorectal manometry, and a balloon expulsion study.

Initial treatment consists of lifestyle modification and laxatives.

Medical treatment should be tailored to the underlying aetiology. If the constipation does not respond to medical treatment, patients may need specialised evaluation for pelvic floor dysfunction and biofeedback therapy. Surgery is only rarely indicated.

Definition

Chronic constipation is a polysymptomatic heterogeneous disorder. Patients define constipation on the basis of excessive straining, a sense of incomplete evacuation, failed or lengthy attempts to defecate, hard stools, and, less frequently, by the number of stools per week.[1][2][3] The American College of Gastroenterology describes constipation as unsatisfactory defecation characterised by infrequent stools, difficult stool passage, or defecation that is both infrequent and/or difficult.[4]

This topic focuses on primary constipation (acute [<3 months] and chronic [≥3 months]) and opioid-induced constipation in adults. For constipation associated with irritable bowel syndrome, see Irritable bowel syndrome. See also Constipation in children.

History and exam

Key diagnostic factors

presence of risk factors
infrequent stools
difficult defecation
sensation of incomplete evacuation
excessive straining

Full details

Other diagnostic factors

hard stools
abdominal mass
signs suggestive of underlying medical disorder
anorectal lesions
abnormality on digital rectal examination (DRE)

Full details

Risk factors

female sex
age >65 years
African ancestry
lower socioeconomic status
family history
sedentary lifestyle
low fibre intake
inadequate calorie intake
inadequate fluid intake
surgical procedures and childbirth
medicines that induce constipation

Full details

Diagnostic investigations

1st investigations to order

full blood count (FBC)
thyroid function tests
serum electrolytes, calcium, and magnesium
blood glucose
quantitative faecal immunochemical test
abdominal x-ray
barium enema

Full details

Investigations to consider

barium defecography
magnetic resonance defecography
colonoscopy
colonic transit study
anorectal manometry
balloon expulsion studies
colonic manometry

Full details

Treatment algorithm

ACUTE

opioid-induced

not opioid-induced: symptoms <3 months

ONGOING

not opioid-induced: symptoms ≥3 months

suspicion for dyssynergia or refractory to pharmacotherapy

Contributors

Authors

Satish Rao, MD, PhD, FRCP (Lon), FACG, AGAF

Professor of Medicine

Chief, Section of Gastroenterology and Hepatology

Director, Digestive Health Center and Neurogastroenterology and GI Motility

Medical College of Georgia

Georgia Regents University

Augusta

Disclosures

SR serves on the advisory board for Vibrant Limited, Sanofi Pharmaceuticals, Viatris Pharmaceuticals, and Takeda Pharmaceuticals of North America. SR is an author of a number of references cited in this topic.

Dariush Shahsavari, MD

Senior Gastroenterology Fellow

Internal Medicine, Division of Gastroenterology/Hepatology

Augusta University

Augusta

Disclosures

DS declares that he has no competing interests.

Acknowledgements

Dr Satish Rao and Dr Dariush Shahsavari would like to gratefully acknowledge Dr Amol Sharma, Dr Humberto Sifuentes, and Dr Ashok Attaluri, previous contributors to this topic.

Disclosures

AS declares that he is on the advisory board for Ironwood Pharmaceuticals. HS declares that he has no competing interests. AA is an author of one reference cited in this topic.

Peer reviewers

Stefan Muller-Lissner, MD

Professor

Abteilung fur Innere Medizin

Park-Klinik Weissensee

Berlin

Germany

Disclosures

SML declares that he has no competing interests.

Eamonn M.M. Quigley, MD, FRCP, FACP, FACG, FRCPI

Professor of Medicine and Human Physiology

Department of Medicine

Clinical Sciences Building

Cork University Hospital

Cork

Ireland

Disclosures

EMMQ has served as a consultant or on advisory boards for the following companies: Sucampo, Movetis, Norgine, Procter and Gamble, Boehringer Ingelheim, Reckitts Benckiser, Schering, Novartis, Salix, Ironwood, and McNeill Consumer Health and has been paid for his time involved. EMMQ is an author of several references cited in this topic.

Ned Snyder, MD

Chief of Gastroenterology and Hepatology

Kelsey-Seybold Clinic

Adjunct Professor of Medicine

University of Texas Medical Branch

Houston

Disclosures

Not disclosed.

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Constipation

Summary

Definition

History and exam

Key diagnostic factors

Other diagnostic factors

Risk factors

Diagnostic investigations

1st investigations to order

Investigations to consider

Treatment algorithm

opioid-induced

not opioid-induced: symptoms <3 months

not opioid-induced: symptoms ≥3 months

suspicion for dyssynergia or refractory to pharmacotherapy

Contributors

Authors

Satish Rao, MD, PhD, FRCP (Lon), FACG, AGAF

Disclosures

Dariush Shahsavari, MD

Disclosures

Acknowledgements

Disclosures

Peer reviewers

Stefan Muller-Lissner, MD

Disclosures

Eamonn M.M. Quigley, MD, FRCP, FACP, FACG, FRCPI

Disclosures

Ned Snyder, MD

Disclosures

Differentials

Guidelines

Patient information

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