确切的病理生理机制尚不可知，但该疾病可能由皮质 - 纹状体 - 丘脑 - 通路失调导致
常见的共病包括焦虑症、强迫症 (OCD) 和注意缺陷多动障碍 (ADHD)
Tanya K. Murphy, MD, MS
JHMACH & USF Maurice A. and Thelma P. Rothman Chair of Developmental Pediatrics
Director, Rothman Center for Neuropsychiatry
Vice-Chair, University of South Florida Pediatrics
Professor, Departments of Pediatrics and Psychiatry
University of South Florida
Johns Hopkins All Children’s Hospital
TKM has received research grants from Auspex Pharmaceuticals, the National Institute of Mental Health, Shire Pharmaceuticals, Pfizer Inc., F. Hoffman-La Roche Ltd., AstraZeneca Pharmaceuticals, Centers for Disease Control and Prevention, Massachusetts General Hospital, Sunovion Pharmaceuticals, Neurocrine Bioscience, Psyadon Pharmaceuticals, and PANDAS Network. She is on the advisory board for the International Obsessive Compulsive Foundation. She is also an author of several references cited in this topic.
Fatima Masumova, DO
Forensic Psychiatry Fellowship, PGY-6
Rutgers Robert Wood Johnson Medical School
FM declares that she has no competing interests.
Cathy L. Budman, MD
National Tourette Centre of Excellence at Northwell Health
Movement Disorders Program in Psychiatry
Hofstra Northwell School of Medicine
CLB has received research funding from Otsuka, Psyadon, Auspex, Teva, Neurocrine, and Synchroneuron Pharmaceuticals. She is a consultant for Bracket and a paid speaker for the Centers for Disease Control and Prevention (CDC) - National Tourette Syndrome Association Partnership. She is an author of several references cited in this topic.
Dr Tanya K. Murphy, Dr Fatima Masumova, and Dr Cathy L. Budman would like to gratefully acknowledge Dr Amber Stocco, Dr Migvis Monduy, and Dr Bobbi Hopkins, previous contributors to this topic. AS, MM, and BH declare that they have no competing interests.
Francis Filloux, MD
Division of Pediatric Neurology
University of Utah School of Medicine
Salt Lake City
FF declares that he has no competing interests.