小结
定义
病史和体格检查
关键诊断因素
- 存在的危险因素
- 肾功能丧失
- 发热
- 皮疹
- 水肿
- 尿量减少
其他诊断因素
- 关节痛
- 葡萄膜炎
危险因素
- 触发药物的使用
- 年龄＞65 岁
- 慢性炎症性疾病
诊断性检查
首要检查
- 血清尿素和肌酐
- 全血细胞计数 (FBC) 与白细胞 (WBC) 分类计数
- 尿液分析
- 停用诱发药物试验
- 抗中性粒细胞胞浆抗体 (ANCA)
- 抗核抗体 (ANA)
- 抗双链 DNA 抗体
- 补体
需考虑的检查
- 肾脏超声
- 肾脏活检
- 肾脏镓扫描
- 尿液细胞因子
治疗流程
有关药物
相关的慢性炎症性疾病
撰稿人
作者
Mark A. Perazella, MD, FACP
Professor of Medicine (Nephrology)
Section of Nephrology
Department of Internal Medicine
Yale School of Medicine
New Haven
CT
利益声明
MAP declares that he has no competing interests. MAP is an author of several references cited in this topic.
Dennis G. Moledina, MBBS, PhD, FASN
Assistant Professor of Medicine (Nephrology)
Department of Internal Medicine (Section of Nephrology)
Clinical and Translational Research Accelerator
Yale School of Medicine
New Haven
CT
利益声明
DGM (via his employer Yale University) has received a grant from the National Institutes of Health and National Institute of Diabetes & Digestive & Kidney Diseases as an investigator (K23DK117065, R01DK128087, and R01DK126815). He is co-inventorof the pending patent application (number 16/536718), 'System and methods for diagnosing acute interstitial nephritis'. He serves on the board of 'Predict AIN, LLC' and has received honorarium from National Kidney Foundation. DGM is an author of several references cited in this topic.
鸣谢
Prof. Mark A. Perazella and Dr Dennis G. Moledina would like to gratefully acknowledge Dr James Marsh, Dr Alice Appel, Dr Gerald Appel, and Dr Kate Shiell, previous contributors to this topic.
利益声明
JM, AA, GA, and KS declare that they have no competing interests.
同行评议者
Irfan Moinuddin, MD
Assistant Professor
Chicago Medical School
Rosalind Franklin University
Lombard
IL
利益声明
IM declares that he has no competing interests.
Catherine Clase, BA, MB, MSC, FRCPC
Associate Professor
Nephrologist
McMaster University
Hamilton
Ontario
Canada
利益声明
CC declares that she has no competing interests.
Robert Mactier, MD, FRCP
Consultant Nephrologist/Lead Clinician
Renal Unit
Glasgow Royal Infirmary
NHS Greater Glasgow and Clyde
Glasgow
UK
利益声明
RM declares that he has no competing interests.
鉴别诊断
- 急性肾小球肾炎
- 急性肾小管坏死
- 急性血管损伤
更多 鉴别诊断指南
- 急性肾损伤：预防、识别和管理
- ACR 适用性标准：肾衰竭
更多 指南
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