When viewing this topic in a different language, you may notice some differences in the way the content is structured, but it still reflects the latest evidence-based guidance.

急性间质性肾炎

最后审阅: 1 Nov 2024
最后更新: 04 Apr 2023

小结

定义

病史和体格检查

关键诊断因素

  • 存在的危险因素
  • 肾功能丧失
  • 发热
  • 皮疹
  • 水肿
  • 尿量减少
完整详情

其他诊断因素

  • 关节痛
  • 葡萄膜炎
完整详情

危险因素

  • 触发药物的使用
  • 年龄>65 岁
  • 慢性炎症性疾病
完整详情

诊断性检查

首要检查

  • 血清尿素和肌酐
  • 全血细胞计数 (FBC) 与白细胞 (WBC) 分类计数
  • 尿液分析
  • 停用诱发药物试验
  • 抗中性粒细胞胞浆抗体 (ANCA)
  • 抗核抗体 (ANA)
  • 抗双链 DNA 抗体
  • 补体
完整详情

需考虑的检查

  • 肾脏超声
  • 肾脏活检
  • 肾脏镓扫描
  • 尿液细胞因子
完整详情

治疗流程

急症处理

有关药物

相关的慢性炎症性疾病

撰稿人

作者

Mark A. Perazella, MD, FACP

Professor of Medicine (Nephrology)

Section of Nephrology

Department of Internal Medicine

Yale School of Medicine

New Haven

CT

利益声明

MAP declares that he has no competing interests. MAP is an author of several references cited in this topic.

Dennis G. Moledina, MBBS, PhD, FASN

Assistant Professor of Medicine (Nephrology)

Department of Internal Medicine (Section of Nephrology)

Clinical and Translational Research Accelerator

Yale School of Medicine

New Haven

CT

利益声明

DGM (via his employer Yale University) has received a grant from the National Institutes of Health and National Institute of Diabetes & Digestive & Kidney Diseases as an investigator (K23DK117065, R01DK128087, and R01DK126815). He is co-inventorof the pending patent application (number 16/536718), 'System and methods for diagnosing acute interstitial nephritis'. He serves on the board of 'Predict AIN, LLC' and has received honorarium from National Kidney Foundation. DGM is an author of several references cited in this topic.

鸣谢

Prof. Mark A. Perazella and Dr Dennis G. Moledina would like to gratefully acknowledge Dr James Marsh, Dr Alice Appel, Dr Gerald Appel, and Dr Kate Shiell, previous contributors to this topic.

利益声明

JM, AA, GA, and KS declare that they have no competing interests.

同行评议者

Irfan Moinuddin, MD

Assistant Professor

Chicago Medical School

Rosalind Franklin University

Lombard

IL

利益声明

IM declares that he has no competing interests.

Catherine Clase, BA, MB, MSC, FRCPC

Associate Professor

Nephrologist

McMaster University

Hamilton

Ontario

Canada

利益声明

CC declares that she has no competing interests.

Robert Mactier, MD, FRCP

Consultant Nephrologist/Lead Clinician

Renal Unit

Glasgow Royal Infirmary

NHS Greater Glasgow and Clyde

Glasgow

UK

利益声明

RM declares that he has no competing interests.

内容使用需遵循免责声明