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湿疹

最后审阅: 22 Nov 2024
最后更新: 07 Aug 2024
07 Aug 2024

湿疹全身治疗新指南

​美国皮肤病学会更新了其 2014 年成人湿疹患者接受光疗和全身治疗的管理指南。[79]

  • 对于需要全身治疗的中度至重度湿疹患者,可考虑使用单克隆抗体度普利尤单抗和 tralokinumab。这两种药物均已获得美国食品药品监督管理局批准用于治疗该适应证。

  • Janus 激酶(Janus kinase, JAK)抑制剂乌帕替尼、阿布昔替尼和巴瑞替尼可作为二线全身治疗药物。乌帕替尼和阿布昔替尼已获得 FDA 批准,用于治疗中度至重度湿疹。

查看治疗:治疗路径

更新原始来源

小结

定义

病史和体格检查

关键诊断因素

  • 存在的危险因素
  • 瘙痒
  • 皮肤干燥
  • 皮肤受累部位
完整详情

其他诊断因素

  • 红斑
  • 鳞屑脱落
  • 水疱
  • 丘疹
  • 毛周角化症
  • 抓痕
  • 苔藓样变
  • 色素减退
完整详情

危险因素

  • 丝聚蛋白基因突变
  • 年龄<5 岁
  • 湿疹家族史
  • 变应性鼻炎
  • 哮喘
  • 主动和被动吸烟
  • 女性
  • 非洲裔美国人
完整详情

诊断性检查

首要检查

  • 临床诊断
完整详情

需考虑的检查

  • IgE水平
  • 皮肤点刺试验
  • 口腔食物激发试验
  • 尝试饮食排除法
  • 斑片试验
  • 皮肤活检
完整详情

治疗流程

急症处理

急性发作

持续性治疗

慢性或复发性疾病

撰稿人

作者

Adelaide A. Hebert, MD

Professor & Director of Pediatric Dermatology

Clinical Specialist

Department of Dermatology and Pediatrics

University of Texas Health Sciences Center at Houston

Houston

TX

利益声明

AAH has received research grants paid to UTHealth McGovern Medical School Houston from Pfizer, GSK, Dermavant, Arcutis, and Novan; has received honoraria from Pfizer, Verrica, and Novan; and is on the data safety monitoring boards for GSK, Ortho Dermatologics, and Regeneron-Sanofi.

Alexander Jafari, MD

Dermatology Clinical Research Fellow

Department of Dermatology

University of Texas Health Science Center at Houston

Houston

TX

利益声明

AJ declares that he has no competing interests.

Matthew Dallo, MD

Clinical Research Fellow

Department of Dermatology

University of Texas Health Science Center at Houston

Houston

TX

利益声明

MD declares that he has no competing interests.

鸣谢

Dr Adelaide A. Hebert, Alexander Jafari, and Dr Matthew Dallo would like to gratefully acknowledge Dr Eugenio G. Galindo, Dr Quoc-Bao D. Nguyen, Dr Mary D. DarConte, Dr Christina M. Gelbard, and Dr Daniel A. Grabella, previous contributors to this topic.

利益声明

EGG, QBDN, MDD, CMG, and DAG declare that they have no competing interests.

同行评议者

Amor Khachemoune, MD

Assistant Professor

New York University School of Medicine

NY

利益声明

AK declares that he has no competing interests.

John English, MBBS, FRCP

Consultant Dermatologist

Department of Dermatology

Queen's Medical Centre

Nottingham University Hospitals

Nottingham

UK

利益声明

JE declares that he has no competing interests.

  • 湿疹 images
  • 鉴别诊断

    • 脂溢性皮炎
    • 刺激性接触性皮炎
    • 过敏性接触性皮炎
    更多 鉴别诊断
  • 指南

    • 成人特应性皮炎光疗和全身治疗管理指南
    • 特应性皮炎的管理指南。 第二部分。 局部用药管理和治疗特应性皮炎患者
    更多 指南
  • 患者教育信息

    湿疹

    更多 患者教育信息
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