最近审阅: 6 十一月 2020
最近更新: 22 三月 2018

小结

定义

病史和体格检查

关键诊断因素

  • 存在的危险因素
  • 身材矮小症
  • 生长速度欠佳
  • 矮于遗传靶身高
  • 缺乏青春期骤长和/或青春期延迟
  • CNS(蝶鞍上部)症状
  • 特征性外貌

其他诊断因素

  • 辅助分娩
  • 新生儿期并发症
  • 隐睾/小阴茎
  • 视觉损害
  • 相关性畸形特征
  • 局灶神经系统功能障碍
  • 食欲亢进症/肥胖
  • 体温失调/睡眠紊乱
  • 行为问题

危险因素

  • GHD 的家族史
  • 其他垂体激素缺乏
  • CNS 肿瘤/囊肿
  • 放射治疗
  • 中线异常
  • CNS 浸润性疾病
  • 围产期并发症
  • CNS 外伤
  • 预先存在的铁超负荷症
  • 虐待儿童
  • 中枢神经系统感染

诊断性检查

首要检查

  • 腕 X 光
  • 甲状腺功能检查 (TFT)
  • IGF1 和 IGFBP3
更多 首要检查

需考虑的检查

  • GH 激发试验
  • 颅脑 MRI 扫描
  • 脑部 CT/颅骨 X 光
  • 垂体激素完整评估
  • 转诊至相应的专科
  • 遗传学检查
  • 随机 GH
更多 需考虑的检查

治疗流程

撰稿人

Ameeta Mehta

Paediatric Endocrinologist

London

UK

利益声明

AM is an author of several references cited in this topic.

Mehul T. Dattani

Professor of Paediatric Endocrinology

Consultant in Paediatric and Adolescent Endocrinology

Great Ormond Street Hospital for Children and

University College London Hospitals

London

UK

利益声明

MTD has received lecture fees from Novo Nordisk, Pfizer, and Ipsen; consultancy fees from Novo Nordisk, Pfizer, Ipsen, and Sandoz; and is a member of a Novo Nordisk advisory board. Novo Nordisk, Pfizer, Ferring, Ipsen, Lilly, Merck, and Serono have made financial contributions to MTD's departmental teaching programme. MTD declares that none of these activities are related to this topic. MTD is an author of a number of references cited in this topic.

Dr Ameeta Mehta and Dr Mehul T. Dattani would like to gratefully acknowledge Dr Kyriaki S. Alatzoglou, a previous contributor to this topic. KSA is an author of a number of references cited in this monograph.

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Professor of Paediatric Endocrinology (Emeritus)

Department of Endocrinology

William Harvey Research Institute

St Bartholomew's and the Royal London School of Medicine and Dentistry

John Vane Science Centre

London

UK

利益声明

MS has received honoraria and consultancy payments from Ipsen, Pfizer, Novo Nordisk, and Merck Serono.

Professor of Pediatrics

Department of Pediatrics (Endocrinology)

Montefiore Medical Center

Albert Einstein College of Medicine

New York

NY

利益声明

PS declares that he has no competing interests.

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