最后审核时间: 八月 2018
最近更新时间: 二月  2018

小结

定义

病史和查体

关键诊断因素

  • 视力丧失
  • 巨颅症和脑积水
  • 生长迟缓

其他诊断因素

  • 促性腺激素分泌不足导致的性腺机能减退症状(闭经、勃起功能障碍)
  • 头痛
  • 颅内压升高的症状(恶心、呕吐、感觉减退和复视)
  • 溢乳
  • 视神经萎缩
  • 烦渴/多饮

危险因素

  • 年龄 5-14 岁
  • 年龄 50 至 70 岁

诊断性检查

首要检查

  • 颅脑 MRI 检查(造影剂增强)
  • 脑 CT 检查(造影剂增强)
  • 血清催乳素
  • 血清生长激素 (growth hormone, GH)
  • 血清胰岛素样生长因子 1 (insulin-like growth factor 1, IGF-1)
  • 血清胰岛素样生长因子结合蛋白-3 (insulin-like growth factor binding protein-3, IGFBP-3)
  • 生长激素刺激试验
  • 血清 LH
  • 血清 FSH
  • 晨间血清睾酮
  • 血清促甲状腺激素 (TSH) 和 T3/T4
  • 晨间血清皮质醇和 ACTH
  • 血清电解质
  • 尿和血清渗透压
  • 尿比重
  • 眼科评估;电脑化视野检查
  • 测骨龄的 X 线平片
全部具体信息

治疗流程

急性
疾病持续状态

贡献者

Marc C. Chamberlain

Chief

Division of Neuro-Oncology

Department of Neurology and Neurological Surgery

University of Washington

Seattle Cancer Care Alliance

Seattle

WA

利益冲突披露

MCC declares that he has no competing interests.

Daniel L. Silbergeld

Professor of Neurological Surgery and Pathology (Neuropathology)

University of Washington

Seattle

WA

利益冲突披露

DLS declares that he has no competing interests.

同行评议专家 查看所有

Professor of Neurology

Department of Neurology

University of Michigan

Ann Arbor

MI

利益冲突披露

LJ declares that he has no competing interests.

Associate Professor of Neurology

Director of Medical Neuro-Oncology

Northwestern University

Chicago

IL

利益冲突披露

JR declares that he has no competing interests.

Consultant Neurosurgeon

Addenbrooke's Hospital

Cambridge University Hospitals NHS Foundation Trust

Cambridge

UK

利益冲突披露

RK declares that he has no competing interests.

Consultant Neurosurgeon and Lead of Neuro-Oncology

King's College Hospital

London

UK

利益冲突披露

KA declares that he has no competing interests.

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