最后审阅: 21 九月 2021
最后更新: 22 四月 2021

小结

定义

病史和体格检查

关键诊断因素

  • 存在的危险因素
  • 乳房肿块
  • 乳头溢液
  • 腋窝淋巴结病

其他诊断因素

  • 皮肤增厚或发黑
  • 乳头内陷或脱皮

危险因素

  • 年龄增长
  • 女性
  • 种族本源
  • 阳性家族史
  • 基因突变
  • 内源性雌激素暴露
  • 外源性雌激素/孕酮暴露
  • 饮酒
  • 放射暴露
  • 良性乳房疾病
  • 乳房密度增高
  • 轻度、中度或显著乳腺背景实质强化
  • 缺乏体力活动
  • 饮食不良
  • 高社会经济等级
  • 吸烟
  • 肥胖
  • 高水平邻苯二甲酸二丁酯暴露

诊断性检查

需考虑的检查

  • 乳腺超声检查
  • 乳房 MRI
  • 活检
  • 激素受体测定
  • HER2 检测
  • 基因表达分析
  • 计算机断层扫描
  • 基因检测
  • 全血细胞计数 (FBC)
  • 肝功能检查 (LFT)
  • 碱性磷酸酶

治疗流程

撰稿人

作者

Krystal Cascetta, MD

Assistant Professor

Division of Hematology and Medical Oncology

Icahn School of Medicine at Mount Sinai

New York

NY

利益声明

KC declares that she has no competing interests.

Amy Tiersten, MD

Professor

Division of Hematology and Medical Oncology

Dubin Breast Center of the Tisch Cancer Institute

New York

NY

利益声明

AT is on the advisory board for Immunomedics, AstraZeneca, Novartis, Eisai, and Healthline. She receives research funding from Pfizer, Novartis, Genentech, Lilly, and AstraZeneca and does expert testimony work.

鸣谢

Dr Krystal Cascetta and Professor Amy Tiersten would like to gratefully acknowledge Dr Hope S. Rugo, Dr Amal Melhem-Bertrandt, Dr Gabriel N. Hortobagyi, and Dr Phuong Khanh H. Morrow, the previous contributors to this topic.

利益声明

AMB, GNH, and PKHM declare that they have no competing interests. HSR receives research funding through the University of California from Novartis, Pfizer, Genentech, Macrogenics, Plexxikon, Merck, Nektar, and GSK. She has been reimbursed for travel by Novartis, Genentech, and Nektar. She has received speaker honorarium from Genomic Health.

同行评议者

Anees Chagpar, MD

Assistant Professor

University of Louisville

Louisville

KY

利益声明

AC declares that she has no competing interests.

Gurhan Celik, MD

General Surgeon

General Surgery Department

Istanbul Training and Research Hospital

Istanbul

Turkey

利益声明

GC is an author of a number of references cited in this topic.

Edward R. Sauter, MD, PhD

Medical Officer

Breast and Gynecologic Cancer Working Group

Division of Cancer Prevention

National Cancer Institute

Bethesda

MD

利益声明

ERS declares that he has no competing interests.

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