常被描述为自发性疼痛、烧灼感疼痛、刀割痛、锐痛、刺痛或电击痛。 典型症状表现为慢性隐痛、钻痛。 几乎总是存在痛觉异常和痛觉过敏
复杂性区域疼痛综合征（complex regional pain syndrome, CRPS）指事件之后出现的与激发事件严重程度不成比例且超出预期正常时间范围的持续（自发和/或诱发性）区域疼痛。疼痛通常为区域性（不在特定的神经区域或皮节），具有远端为主的感觉、运动、催汗、血管舒缩和/或营养状况异常，随着时间变化进展各不相同
Nicholas Shenker, BM BCh, MA, PhD, FRCP
Consultant in Rheumatology
Cambridge University Hospitals NHS Foundation Trust
NS is medical adviser to Cambridge Nutraceuticals with stock options. He has received consultancy fees from Roche to provide unrestricted sponsored educational meetings, and grants from Versus Arthritis, the National Institute for Health Research Clinical Research Network, and the Medical Research Council. NS is an author of references cited in this topic.
Gaurav Chhabra, MBBS, FRCA, FFPMRCA
Consultant in Pain Medicine and Anaesthesia
North Bristol NHS Trust
GC has been sponsored by Medtronic, Boston Scientific, Abbott, Nevro, Stimwave, and Polar Medical for attending various conferences and cadaveric workshops relevant to pain medicine and neuromodulation. GC is an associate examiner for the European Society of Regional Anaesthesia & Pain Therapy European Diploma of Pain Medicine exam and is also the regional advisor for pain medicine for the South West Severn deanery.
Dr Nicholas Shenker and Dr Gaurav Chhabra would like to gratefully acknowledge Dr Steven H. Horowitz, a previous contributor to this topic.
SHH declares that he has no competing interests.
Andre Tomasino, MD
Department of Neurological Surgery
Weill Cornell Medical College
New York-Presbyterian Hospital
AT declares that he has no competing interests.
Ari Weinreb, MD, PhD
Associate Chief of Rheumatology
VA Greater Los Angeles Healthcare System
Associate Professor of Medicine
David Geffen School of Medicine
AW declares that he has no competing interests.
Jonathan Berman, MBBS
Consultant in Pain Management and Anaesthesia
Pain Management Department
Royal National Orthopaedic Hospital NHS Trust
JB has been reimbursed by Pfizer for lectures given at Pfizer-sponsored meetings and courses.