最近审阅: 26 十月 2020
最近更新: 14 十一月 2018

小结

定义

病史和体格检查

关键诊断因素

  • 存在的危险因素
  • 雷诺现象 (RP)
  • 吞咽困难
  • 胃食管反流病 (GORD)
  • 扩张的甲床毛细血管
  • 手足皮肤明亮有光泽
  • 手指对称肿胀,紧绷
  • 祈祷征
  • 爪形手畸形
  • 手指溃疡
  • 双手屈曲挛缩
  • 腕管综合征
  • 钙质沉着
  • 大面积界限清楚的毛细血管扩张

其他诊断因素

  • 皮肤色素改变
  • 结缔组织病家族史

危险因素

  • 矽尘暴露
  • 硬皮病家族史
  • 聚氯乙烯

诊断性检查

首要检查

  • 全血细胞计数
  • 血清肌酐
  • 血清抗核抗体
  • 血清可提取性核抗原
  • 血清红细胞沉降率 (ESR)
  • 超声心动图
  • 肺功能检查 (PFT)
更多 首要检查

需考虑的检查

  • 外周血涂片
  • 抗着丝点抗体
  • 食管压力测定
更多 需考虑的检查

治疗流程

急性处理
进行中

撰稿人

Janet E. Pope

Professor of Medicine

Division of Rheumatology

Department of Medicine

Schulich School of Medicine and Dentistry

University of Western Ontario

Head

Division of Rheumatology

St. Joseph's Health Care

London

Ontario

Canada

利益声明

JEP has consulted for and/or performed research trials with AbbVie, Actelion, Amgen, BMS, Lilly, Merck, Novartis, Pfizer, Roche, Sandoz, Sanofi, and United Chemicals Belgium. JEP is an author of several references cited in this topic.

同行评议者展开全部内容

Professor of Medicine

Georgetown University

Washington

DC

利益声明

VS has received research funding, consulting fees, and honorarium from Actelion and Gilead, which could result in competing interests. VS is an author of a number of references cited in this topic.

Emeritus Professor

Department of Rheumatology

Lund University Hospital

Lund

Sweden

利益声明

FW is an author of a reference cited in this topic.

Charité-Universitätsmedizin Berlin

Medizinische Klinik mit Schwerpunkt

Rheumatologie und Klinische Immunologie

Charitéplatz

Berlin

Germany

利益声明

GR is a consultant for Encysive, Actelion, Bayer, GSK, Roche, and other companies, and received lecture fees from all of these companies involved in systemic scleroderma. GR is an author of a reference cited in this topic.

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