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鱼鳞病

最后审阅: 13 Oct 2024
最后更新: 11 Jan 2022

小结

定义

病史和体格检查

关键诊断因素

  • 鳞屑脱落
  • 出生时的皮肤改变(见于先天性鱼鳞病)
  • 发生在婴儿期(见于寻常型和X连锁鱼鳞病)
  • 成年发病(见于获得性鱼鳞病)
  • 男性
  • 鱼鳞病家族史
完整详情

其他诊断因素

  • 过敏史
  • 淋巴瘤、糖尿病、系统性红斑狼疮病史
  • 使用氯法齐明、降脂药物或丁酰苯。
  • 脱发和睑外翻见于板层状鱼鳞病
  • 隐睾症和角膜混浊
  • 耳聋、智力障碍、肢体缺陷、癫痫、身材矮小
完整详情

危险因素

  • 阳性家族史
  • 近亲结婚
  • 使用氯法齐明、降脂药物或丁酰苯。
  • 淋巴瘤、糖尿病、系统性红斑狼疮病史
完整详情

诊断性检查

首要检查

  • 皮肤活检
  • 血清胆固醇硫酸盐
  • 脂蛋白电泳
  • 类固醇硫酸酯酶活性
完整详情

需考虑的检查

  • 血清植烷酸
  • 基因检测
  • CT 扫描
  • 血清葡萄糖
  • 抗核抗体
完整详情

治疗流程

持续性治疗

原发性(遗传性)

继发性(获得性)

撰稿人

作者

Brittany Craiglow, MD

Associate Adjunct Professor of Dermatology

Yale University

New Haven

CT

利益声明

BC declares that she is a member of the Foundation for Ichthyosis and Related Skin Types Advisory Board. BC is an author of a reference cited in this topic.

鸣谢

Dr Brittany Craiglow would like to gratefully acknowledge Dr Timothy Patton, a previous contributor to this topic.

利益声明

TP declared that he had no competing interests.

同行评议者

David Cassarino, MD, PhD

Assistant Professor

Department of Pathology and Laboratory Medicine

University of California

Los Angeles

CA

利益声明

DC declares that he has no competing interests.

Thierry Simonart, MD, PhD

Physician

Department of Dermatology

Erasme University Hospital

Brussels

Belgium

利益声明

TS declares that he has no competing interests.

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