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佩吉特骨病

最后审阅: 6 Oct 2024
最后更新: 01 Sep 2022

小结

定义

病史和体格检查

关键诊断因素

  • PDB 家族史
  • 无症状
完整详情

其他诊断因素

  • 累及股骨、骨盆和/或颅骨
  • 长骨或背部疼痛
  • 病理性骨折
  • 骨骼畸形(例如额部隆起、下颌前突、骨弯曲)
  • 局部体温增加
  • 听力损失
  • 面部疼痛
  • 牙齿松动或咀嚼障碍
  • 碱性磷酸酶孤立性升高
完整详情

危险因素

  • PDB 家族史
  • 年龄>50 岁
  • 男性(45~74 岁)
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诊断性检查

首要检查

  • X 线平片
  • 骨扫描
  • 血清总碱性膦酸酶
  • 骨特异性碱性膦酸酶
  • 血清钙
  • 血清原胶原 1 N-端肽 (P1NP)
  • I 型胶原血清 C-端前肽 (CTX)
  • 肝功能检测
  • 血清 25 -羟基维生素 D
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需考虑的检查

  • CT 扫描或 MRI
  • 骨活检
完整详情

治疗流程

持续性治疗

无症状患者,偶然诊断

有症状患者

撰稿人

作者

Roberto Civitelli, MD

Sydney M. & Stella H. Schoenberg Professor of Medicine

Professor of Orthopaedic Surgery and Cell Biology and Physiology

Chief, Division of Bone and Mineral Diseases

Musculoskeletal Research Center

Washington University School of Medicine

St. Louis

MO

利益声明

RC is Editor-in-Chief of the Journal of Bone and Mineral Research (position ending 31/12/2022).

Mahshid Mohseni, MD, MSci

Assistant Professor

Director, Clinical Research Unit

Co-Director, Clinical Operations

Division of Bone and Mineral Diseases

Department of Medicine

Washington University School of Medicine

St. Louis

MO

利益声明

MM declares that he has no competing interests.

鸣谢

Dr Roberto Civitelli and Dr Mahshid Mohseni would like to gratefully acknowledge Dr Julia F. Charles, Dr Camilo Restrepo, and Dr Javad Parvizi, previous contributors to this topic.

利益声明

JFC has received royalties from Up To Date, Waltham, MA, for authorship on articles relating to PDB; received grant funding from the National Institues of Health, the Rheumatology Research Foundation, and Brigham and Women's Hospital for research into regulation of osteoclast function, but not specifically relating to PDB; and had a manuscript published from a collaboration with Dr Jae Shim describing a pagetic phenotype in mice with osteoclast-specific loss of Chmp5. CR and JP are authors of a reference cited in this topic.

同行评议者

Frederick Singer, MD

Director

Endocrine/Bone Disease Program

John Wayne Cancer Institute

Santa Monica

CA

利益声明

FS declares that he has no competing interests.

Joseph Lane, MD

Orthopaedic Surgeon

Hospital for Special Surgery

New York

NY

利益声明

JL declares that he has no competing interests.

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