最近审阅: 24 十月 2020
最近更新: 29 一月 2019

小结

定义

病史和体格检查

其他诊断因素

  • 累及股骨、骨盆和/或颅骨
  • 长骨或背部疼痛
  • 病理性骨折
  • 骨骼畸形(例如额部隆起、下颌前突、骨弯曲)
  • 局部体温增加
  • 听力受损
  • 面部疼痛
  • 牙齿松动或咀嚼障碍
  • 视觉灵敏度减退

危险因素

  • Paget 病家族史
  • 年龄>50 岁
  • 男性(45~74 岁)
  • 感染
  • 环境因素

诊断性检查

首要检查

  • X 线平片
  • 骨扫描
  • 血清总碱性膦酸酶
  • 骨特异性碱性膦酸酶
  • 血清钙
  • 血清原胶原 1 N-端肽 (P1NP)
  • I 型胶原血清 C-端前肽 (CTX)
  • 肝功能检查 (LFT)
  • 血清 25 -羟基维生素 D
更多 首要检查

治疗流程

撰稿人

Associate Physician

Assistant Professor of Medicine

Brigham and Women's Hospital

Department of Orthopaedics and Medicine/Rheumatology

Boston

MA

利益声明

JFC has received royalties from Up To Date, Waltham, MA, for authorship on articles relating to Paget disease of bone (PDB). JFC has also received grant funding from the NIH, Rheumatology Research Foundation and Brigham and Women's Hospital for research into regulation of osteoclast function, but not specifically relating to PDB. JFC has had a manuscript published from a collaboration with Dr. Jae Shim describing a Pagetic phenotype in mice with osteoclast-specific loss of Chmp5.

Dr Julia F. Charles would like to gratefully acknowledge Dr Camilo Restrepo and Dr Javad Parvizi, previous contributors to this topic. CR and JP are authors of references cited in this topic.

同行评议者展开全部内容

Director

Endocrine/Bone Disease Program

John Wayne Cancer Institute

Santa Monica

CA

利益声明

FS declares that he has no competing interests.

Orthopaedic Surgeon

Hospital for Special Surgery

New York

NY

利益声明

JL declares that he has no competing interests.

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