最近审阅: 30 十月 2020
最近更新: 05 一月 2018

小结

定义

病史和体格检查

关键诊断因素

  • 40 至 60 岁
  • 发热
  • 体重减轻
  • 肌痛或关节痛
  • 多发性单神经炎
  • 感觉异常
  • 肌肉压痛
  • 腹痛
  • 皮肤表现
  • 舒张压>90 mmHg
  • 在乙型肝炎病毒常规筛查前的输血史
  • 既往或现在静脉吸毒
  • 乙型肝炎病毒 (HBV) 的近期感染
  • 睾丸痛

其他诊断因素

  • 男性
  • 毛细胞白血病
  • 癫痫发作
  • 上运动神经元无力
  • 消化道出血
  • 腹膜炎
  • 单眼失明
  • 胸痛
  • 充血性心力衰竭
  • 触痛性乳房肿块

危险因素

  • 乙型肝炎病毒 (HBV) 感染
  • 40 至 60 岁
  • 毛细胞白血病
  • 在乙型肝炎病毒常规筛查前的输血史
  • 丙型肝炎病毒 (HCV) 感染
  • 男性

诊断性检查

首要检查

  • C 反应蛋白 (CRP)
  • 红细胞沉降率 (ESR)
  • 全血细胞计数 (FBC)
  • 补体
  • 血清肌酐
  • 中段尿分析
  • 肝功能检查
  • HBV 血清学检查
  • 丙型肝炎病毒 (HCV) 血清学
  • 冷球蛋白
  • 血液培养
  • 肌酸激酶
  • 抗中性粒细胞胞质抗体 (ANCA)
  • 抗核抗体 (ANA)
  • 抗双链 DNA 抗体(抗 dsDNA)
  • 类风湿因子
  • 抗环瓜氨酸肽(抗 CCP 抗体)
  • 狼疮抗凝物
  • IgG 抗磷脂抗体
  • B2 糖蛋白
  • 纤维蛋白原
  • 传统数字减影血管造影
  • 超声心动图
更多 首要检查

需考虑的检查

  • 磁共振血管成像 (MRA)
  • CT 血管造影术
  • 受累组织活检
  • HIV 血清学
更多 需考虑的检查

治疗流程

撰稿人

Consultant Rheumatologist

Auckland and Counties Manukau District Health Boards

Auckland

New Zealand

利益声明

RS declares that he has no competing interests.

Rheumatology Registrar

Nuffield Orthopaedic Centre

Oxford

UK

利益声明

JR has attended symposia sponsored by Roche Ltd.

Professor of Medicine

Rheumatology Department

Hopital Cochin

Paris

France

利益声明

LG is an author of a number of references cited in this monograph.

Professor of Rheumatology

NIHR Musculoskeletal Biomedical Research Unit

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science

University of Oxford

Oxford

UK

利益声明

RL has attended symposia sponsored by GlaxoSmithKline, the manufacturer of Epivir (lamivudine), and has received sponsorship from Roche, Abbot Ltd, Schering Plough (the manufacturer of Remicade [infliximab]), and Wyeth (the manufacturer of Enbrel [etanercept]) to attend conferences. RL has received sponsorship from Sanofi Aventis (the manufacturer of Arava [leflunomide]) to support the costs of a meeting, and is on the Roche advisory board looking at treatment of vasculitis with B cell therapy. RL is an author of a number of references cited in this monograph.

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Professor and Vice Chair

Department of Medicine

University of Wisconsin Hospital

Madison

WI

利益声明

AB declares that he has no competing interests.

Consultant Rheumatologist

Ipswich Hospital

Ipswich

UK

利益声明

RW has received fees for consulting from Roche Pharmaceuticals, manufacturer of rituximab. His department has received financial support from Wyeth Pharmaceuticals, manufacturer of etanercept, and from Schering-Plough, manufacturer of infliximab. RW is an author of a number of references cited in this monograph.

Professor of Medicine

Department of Medicine

UMDNJ-Robert Wood Johnson Medical School

New Brunswick

NJ

利益声明

ECE declares that she has no competing interests.

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